山本和秀

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

著者	Tatsukawa, Masashi\| Takaki, Akinobu\| Shiraha, Hidenori\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Kobashi, Haruhiko\| Fujioka, Shin-Ichi\| Sakaguchi, Kohsaku\| Yamamoto, Kazuhide\|
発行日	2011-10-21
出版物タイトル	BMC Cancer
巻	11巻
資料タイプ	学術雑誌論文

Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor

JaLCDOI	10.18926/AMO/52139
フルテキストURL	68_1_17.pdf
著者	Moritou, Yuki\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Baba, Nobuyuki\| Takaguchi, Kouichi\| Senoh, Tomonori\| Nagano, Takuya\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Ohnishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
抄録	The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy.
キーワード	hepatic steatosis genetic polymorphism interferon HCV
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	17
終了ページ	22
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553484
Web of Science KeyUT	000331592800003

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

著者	Kinugasa, Hideaki\| Nouso, Kazuhiro\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Nakamura, Shin-ichiro\| Shiraha, Hidenori\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Ikeda, Fusao\| Miyake, Yasuhiro\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-04
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	4号
資料タイプ	学術雑誌論文

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

著者	Onji, Masahiro\| Kanno, Atsuo\| Saitoh, Shin-Ichiroh\| Fukui, Ryutaro\| Motoi, Yuji\| Shibata, Takuma\| Matsumoto, Fumi\| Lamichhane, Aayam\| Sato, Shintaro\| Kiyono, Hiroshi\| Yamamoto, Kazuhide\| Miyake, Kensuke\|
発行日	2013-06
出版物タイトル	Nature Communications
巻	4巻
資料タイプ	学術雑誌論文

Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population

著者	Kubota, Junichi\| Ikeda, Fusao\| Terada, Ryo\| Kobashi, Haruhiko\| Fujioka, Shin-ichi\| Okamoto, Ryoichi\| Baba, Shinsuke\| Morimoto, Youichi\| Ando, Masaharu\| Makino, Yasuhiro\| Taniguchi, Hideaki\| Yasunaka, Tetsuya\| Miyake, Yasuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
発行日	2009-09
出版物タイトル	Journal of Gastroenterology
巻	44巻
号	9号
資料タイプ	学術雑誌論文

DNA Methylation of Colon Mucosa in Ulcerative Colitis Patients: Correlation with Inflammatory Status

著者	Saito, Shunsuke\| Kato, Jun\| Hiraoka, Sakiko\| Horii, Joichiro\| Suzuki, Hideyuki\| Higashi, Reiji\| Kaji, Eisuke\| Kondo, Yoshitaka\| Yamamoto, Kazuhide\|
発行日	2011-09
出版物タイトル	Inflammatory Bowel Diseases
巻	17巻
号	9号
資料タイプ	学術雑誌論文

Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma

著者	Matsubara, Minoru\| Shiraha, Hidenori\| Kataoka, Jyunro\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Nishina, Shin-ichi\| Takaoka, Nobuyuki\| Uemura, Masayuki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012-10
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	27巻
号	10号
資料タイプ	学術雑誌論文

Management of Occluded Metallic Stents in Malignant Hilar Biliary Stricture

著者	Fujii, Masakuni\| Kawamoto, Hirofumi\| Tsutsumi, Koichiro\| Kato, Hironari\| Hirao, Ken\| Kurihara, Naoko\| Mizuno, Osamu\| Ishida, Etsuji\| Ogawa, Tsuneyoshi\| Fukatsu, Hirotoshi\| Yamamoto, Kazuhide\|
発行日	2013-05
出版物タイトル	Hepato-Gastroenterology
巻	60巻
号	123号
資料タイプ	学術雑誌論文

免疫学的便潜血定量法による潰瘍性大腸炎の粘膜治癒評価

著者	半井明日香\| 加藤順\| 平岡佐規子\| 栗山宗彰\| 井口俊博\| 竹井大介\| 森藤由記\| 秋田光洋\| 高橋索真\| 原田馨太\| 岡田裕之\| 山本和秀\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文

NASHに対する水素分子の有用性

著者	河合大介\| 高木章乃夫\| 山本和秀\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文

Is Presence or History of Extracolonic Primary Malignancy a Risk for Colorectal Neoplasia? An Analysis of Patients Who Underwent Colonoscopy

JaLCDOI	10.18926/AMO/51864
フルテキストURL	67_5_285.pdf
著者	Akita, Mitsuhiro\| Hiraoka, Sakiko\| Kaji, Eisuke\| Takemoto, Koji\| Nagahara, Yasuhiro\| Yamamoto, Hiroshi\| Yamamoto, Kazuhide\| Kato, Jun\|
抄録	Whether presence or history of extracolonic primary malignancy is a risk for colorectal neoplasia is not fully known. In this study, 26,452 first-time colonoscopy cases were examined using a colonoscopy database. Among the analyzed subjects, 3,026 (11%) subjects had history or concomitance of extracolonic primary malignancy, while the remaining 23,426 subjects did not. Colorectal neoplasia was observed in 39% of all the subjects. A crude comparison showed that the prevalence of any type of colorectal neoplasia was higher in subjects with extracolonic malignancy than in those without (42% vs. 39%, p＝0.0012). However, after adjusting for confounding factors, the odds ratios (ORs) of subjects with extracolonic malignancy for having colorectal neoplasia, advanced neoplasia, and cancer were all less than 1.0, and all significantly different from those of subjects without extracolonic malignancy. Analysis according to the type of extracolonic malignancy revealed that gastric cancer cases had a significantly lower risk for colorectal advanced neoplasia (OR:0.81;95% CI:0.67-0.99). Among major malignancies, only esophageal squamous cell cancer cases had increased risk for colorectal neoplasia (OR:1.66;95% CI:1.20-2.29). Patients with presence or history of extracolonic malignancy did not carry a higher risk of occurrence of colorectal neoplasia.
キーワード	colorectal cancer colonoscopy risk factor database
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-10
巻	67巻
号	5号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	292
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24145728
Web of Science KeyUT	000325836100002

Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma

著者	Nishimura, Mamoru\| Takaki, Akinobu\| Tamaki, Naofumi\| Maruyama, Takayuki\| Onishi, Hideki\| Kobayashi, Sayo\| Nouso, Kazuhiro\| Yasunaka, Tetsuya\| Koike, Kazuko\| Hagihara, Hiroaki\| Kuwaki, Kenji\| Nakamura, Shinichiro\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Tomofuji, Takaaki\| Morita, Manabu\| Yamamoto, Kazuhide\|
発行日	2013-01-30
出版物タイトル	Hepatology Research
巻	43巻
号	10号
資料タイプ	学術雑誌論文

Monitoring of CA19-9 and SPan-1 can facilitate the earlier confirmation of progressing pancreatic cancer during chemotherapy

著者	Tsutsumi, Koichiro\| Kawamoto, Hirofumi\| Hirao, Ken\| Sakakihara, Ichiro\| Yamamoto, Naoki\| Noma, Yasuhiro\| Fujii, Masakuni\| Kato, Hironari\| Ogawa, Tsuneyoshi\| Ishida, Etsuji\| Kuwaki, Kenji\| Nouso, Kazuhiro\| Okada, Hiroyuki\| Yamamoto, Kazuhide\|
発行日	2012-09
出版物タイトル	Pancreatology
巻	12巻
号	5号
資料タイプ	学術雑誌論文

Utility of Contrast-Enhanced FDG-PET/CT in the Clinical Management of Pancreatic Cancer Impact on Diagnosis, Staging, Evaluation of Treatment Response, and Detection of Recurrence

著者	Asagi, Akinori\| Ohta, Koji\| Nasu, Junichirou\| Tanada, Minoru\| Nadano, Seijin\| Nishimura, Rieko\| Teramoto, Norihiro\| Yamamoto, Kazuhide\| Inoue, Takeshi\| Iguchi, Haruo\|
発行日	2013-01
出版物タイトル	Pancreas
巻	42巻
号	1号
資料タイプ	学術雑誌論文

著者	Tanaka, Shigetomi\| Shiraha, Hidenori\| Nakanishi, Yutaka\| Nishina, Shin-Ichi\| Matsubara, Minoru\| Horiguchi, Shigeru\| Takaoka, Nobuyuki\| Iwamuro, Masaya\| Kataoka, Junro\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Toshimori, Junichi\| Ohnishi, Hideki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2012-12-01
出版物タイトル	International Journal of Cancer
巻	131巻
号	11号
資料タイプ	学術雑誌論文

The Genetic Diversity of Helicobacter pylori Virulence Genes Is Not Associated with Gastric Atrophy Progression

JaLCDOI	10.18926/AMO/49667
フルテキストURL	67_2_93.pdf
著者	Kita, Masahide\| Yokota, Kenji\| Okada, Hiroyuki\| Take, Susumu\| Takenaka, Ryuta\| Kawahara, Yoshiro\| Oguma, Keiji\| Matsushita, Osamu\| Yamamoto, Kazuhide\|
抄録	Atrophy of the gastric mucosa is a precursor of intestinal-type gastric cancer, and Helicobacter pylori infection causes atrophic gastritis. The aim of this study was to determine whether the genetic diversity of H. pylori virulence genes is associated with the development and progression of gastric atrophy in humans. We isolated and cultured H. pylori strains from patients with gastric ulcer and duodenal ulcer accompanied by atrophic gastritis in background mucosa. H. pylori strains were stored at －80℃ prior to the experiments being carried out. We analyzed iceA, babA, vacA, cagA, and cagE genes by PCR. The cagA gene was analyzed through sequencing of the C-terminal region containing the EPIYA motif, which is related to tyrosine phosphorylation. Severe atrophy was observed in patients with gastric ulcer. The major phenotype of the vacA gene was s1c/m1 (93ｵ). The cagA gene was detected in all strains. The cagE gene was not detected in 2 and 5 strains from the mild cases and severe cases, respectively. The major cagA EPIYA motif, which is amino acids repeat in the C terminus, was the A-B-D type (44 of 58 strains). The virulence genes were not statistically associated with the severity of atrophy in the background gastric mucosa in humans. Not only identification of bacterial virulence factors but also studies of the host response will be necessary to investigate the progression of gastric atrophy and subsequent cancer development in humans.
キーワード	Helicobacter pylori virulence genes chronic atrophic gastritis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	93
終了ページ	98
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603925
Web of Science KeyUT	000317801700003
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52508

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT)

著者	Hirakawa, Tomoko\| Kato, Jun\| Okumura, Yoshihiro\| Hori, Keisuke\| Takahashi, Sakuma\| Suzuki, Hideyuki\| Akita, Mitsuhiro\| Higashi, Reiji\| Saito, Shunsuke\| Kaji, Eisuke\| Uraoka, Toshio\| Hiraoka, Sakiko\| Yamamoto, Kazuhide\|
発行日	2012-02
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	2号
資料タイプ	学術雑誌論文

Eradication of Hepatitis C Virus Subgenomic Replicon by Interferon Results in Aberrant Retinol-Related Protein Expression

JaLCDOI	10.18926/AMO/49042
フルテキストURL	66_6_461.pdf
著者	Koike, Kazuko\| Takaki, Akinobu\| Kato, Nobuyuki\| Ouchida, Mamoru\| Kanzaki, Hirotaka\| Yasunaka, Tetsuya\| Shiraha, Hidenori\| Miyake, Yasuhiro\| Yamamoto, Kazuhide\|
抄録	Hepatitis C virus (HCV) infection induces several changes in hepatocytes, such as oxidative stress, steatosis, and hepatocarcinogenesis. Although considerable progress has been made during recent years, the mechanisms underlying these functions remain unclear. We employed proteomic techniques in HCV replicon-harboring cells to determine the effects of HCV replication on host-cell protein expression. We examined two-dimensional electrophoresis (2-DE) and mass spectrometry to compare and identify differentially expressed proteins between HCV subgenomic replicon-harboring cells and their “cured” cells. One of the identified proteins was confirmed using enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Full-length HCV genome RNA replicating and cured cells were also assessed using ELISA. Replicon-harboring cells showed higher expression of retinal dehydrogenase 1 (RALDH-1), which converts retinol to retinoic acid, and the cured cells showed higher expression of retinol-binding protein (RBP), which transports retinol from the liver to target tissues. The alteration in RBP expression was also confirmed by ELISA and Western blot analysis. We conclude that protein expression profiling demonstrated that HCV replicon eradication affected retinol-related protein expression.
キーワード	hepatitis C virus retinol-binding protein
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-12
巻	66巻
号	6号
出版者	Okayama University Medical School
開始ページ	461
終了ページ	468
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23254580
Web of Science KeyUT	000312966100005

著者	Nakanishi, Yutaka\| Shiraha, Hidenori\| Nishina, Shin-ichi\| Tanaka, Shigetomi\| Matsubara, Minoru\| Horiguchi, Shigeru\| Iwamuro, Masaya\| Takaoka, Nobuyuki\| Uemura, Masayuki\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Toshimori, Junichi\| Ohnishi, Hideki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2011-01-04
出版物タイトル	BMC Cancer
巻	11巻
資料タイプ	学術雑誌論文

Twist expression promotes migration and invasion in hepatocellular carcinoma

著者	Matsuo, Noriyuki\| Shiraha, Hidenori\| Fujikawa, Tatsuya\| Takaoka, Nobuyuki\| Ueda, Naoki\| Tanaka, Shigetomi\| Nishina, Shinichi\| Nakanishi, Yutaka\| Uemura, Masayuki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2009-07-18
出版物タイトル	BMC Cancer
巻	9巻
資料タイプ	学術雑誌論文

山本 和秀