| フルテキストURL | CCP_fulltext.pdf |
|---|---|
| 著者 | Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| キーワード | Breast cancer Metformin Preoperative Tils CD8 PD-L1 |
| 発行日 | 2020-06-12 |
| 出版物タイトル | Cancer Chemotherapy and Pharmacology |
| 巻 | 86巻 86巻 |
| 号 | 1号 1号 |
| 出版者 | Springer |
| 開始ページ | 55 55 |
| 終了ページ | 63 63 |
| ISSN | 0344-5704 |
| NCID | AA00598397 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©Author(s) |
| 論文のバージョン | publisher |
| PubMed ID | 32533334 |
| DOI | 10.1007/s00280-020-04092-2 |
| Web of Science KeyUT | 000539841500002 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00280-020-04092-2 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fujihara, Miwa| Shien, Tadahiko| Shien, Kazuhiko| Suzawa, Ken| Takeda, Tatsuaki| Zhu, Yidan| Mamori, Tomoka| Otani, Yusuke| Yoshioka, Ryo| Uno, Maya| Suzuki, Yoko| Abe, Yuko| Hatono, Minami| Tsukioki, Takahiro| Takahashi, Yuko| Kochi, Mariko| Iwamoto, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| キーワード | breast cancer YES1 T-DM1 dasatinib drug resistance |
| 発行日 | 2021-11-26 |
| 出版物タイトル | International Journal Of Molecular Sciences |
| 巻 | 22巻 |
| 号 | 23号 |
| 出版者 | MDPI |
| 開始ページ | 12809 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34884609 |
| DOI | 10.3390/ijms222312809 |
| Web of Science KeyUT | 000735641400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms222312809 |
| フルテキストURL | fulltext20210527_4.pdf |
|---|---|
| 著者 | Ishikawa, Takashi| Sakamaki, Kentaro| Narui, Kazutaka| Nishimura, Hideki| Sangai, Takafumi| Tamaki, Kentaro| Hasegawa, Yoshie| Watanabe, Ken-ichi| Suganuma, Nobuyasu| Michishita, Shintaro| Sugae, Sadatoshi| Aihara, Tomohiko| Tsugawa, Koichiro| Kaise, Hirose| Taira, Naruto| Mukai, Hirofumi| |
| キーワード | Breast cancer Febrile neutropenia Adjuvant chemotherapy Risk factors Prospective study |
| 発行日 | 2021-04-30 |
| 出版物タイトル | The Breast |
| 巻 | 56巻 |
| 出版者 | Elsevier |
| 開始ページ | 70 |
| 終了ページ | 77 |
| ISSN | 09609776 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 33631458 |
| DOI | 10.1016/j.breast.2021.01.005 |
| Web of Science KeyUT | 000632058800010 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.breast.2021.01.005 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsurutani, Junji| Hara, Fumikata| Kitada, Masahiro| Takahashi, Masato| Kikawa, Yuichiro| Kato, Hiroaki| Sakata, Eiko| Naito, Yoichi| Hasegawa, Yoshie| Saito, Tsuyoshi| Iwasa, Tsutomu| Taira, Naruto| Takashima, Tsutomu| Kashiwabara, Kosuke| Aihara, Tomohiko| Mukai, Hirofumi| |
| キーワード | Nab-paclitaxel Nanoparticle albumin–bound paclitaxel Metastatic breast cancer Solvent-base paclitaxel Chemotherapy-induced peripheral neuropathy |
| 発行日 | 2020-12-09 |
| 出版物タイトル | The Breast |
| 巻 | 55巻 |
| 出版者 | Elsevier |
| 開始ページ | 63 |
| 終了ページ | 68 |
| ISSN | 0960-9776 |
| NCID | AA10844161 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 The Authors. |
| 論文のバージョン | publisher |
| DOI | 10.1016/j.breast.2020.12.002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.breast.2020.12.002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Suzuki, Yoko| Taniguchi, Kohei| Hatono, Minami| Kajiwara, Yukiko| Abe, Yuko| Kawada, Kengo| Tsukioki, Takahiro| Kochi, Mariko| Nishiyama, Keiko| Iwamoto, Takayuki| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Tabata, Masahiro| Yanai, Hiroyuki| Doihara, Hiroyoshi| |
| キーワード | Radiation-induced angiosarcoma Radiotherapy Breast-conserving surgery Breast cancer Paclitaxel therapy Adjuvant therapy of angiosarcoma |
| 発行日 | 2020-01-16 |
| 出版物タイトル | Surgical Case Reports |
| 巻 | 6巻 |
| 号 | 1号 |
| 出版者 | SpringerOpen |
| 開始ページ | 25 |
| ISSN | 2198-7793 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s). 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 31950295 |
| DOI | 10.1186/s40792-020-0790-7 |
| Web of Science KeyUT | 000513920900001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40792-020-0790-7 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takahashi, Yuko| Iwamoto, Takayuki| Suzuki, Yoko| Kajiwara, Yukiko| Hatono, Minami| Tsukioki, Takahiro| Kawada, Kengo| Kochi, Mariko| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| キーワード | Gene expression Hormone receptor positive Residual tumor burden Targeted therapy Triple negative |
| 発行日 | 2020-04 |
| 出版物タイトル | Clinical Breast Cancer |
| 巻 | 20巻 |
| 号 | 2号 |
| 出版者 | Elsevier |
| 開始ページ | 117 |
| 終了ページ | 124 |
| ISSN | 1526-8209 |
| NCID | AA11694891 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 31570267 |
| DOI | 10.1016/j.clbc.2019.07.001 |
| Web of Science KeyUT | 000529805200021 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.clbc.2019.07.001 |
| フルテキストURL | BreastCancer_24_4_593.pdf BreastCancer_24_4_593_tbl_fig.pdf |
|---|---|
| 著者 | Saiga, Miho| Taira, Naruto| Kimata, Yoshihiro| Watanabe, Satoko| Mukai, Yuko| Shimozuma, Kojiro| Mizoo, Taeko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| |
| キーワード | BREAST-Q Breast cancer Breast reconstruction Health-related quality of life Satisfaction |
| 発行日 | 2017-03 |
| 出版物タイトル | Breast Cancer |
| 巻 | 24巻 |
| 号 | 2号 |
| 出版者 | Japanese Breast Cancer Society |
| 開始ページ | 288 |
| 終了ページ | 298 |
| ISSN | 1340-6868 |
| NCID | AA1103354X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 27179527 |
| DOI | 10.1007/s12282-016-0703-6 |
| Web of Science KeyUT | 000395524900012 |
| 関連URL | isVerionOf https://doi.org/10.1007/s12282-016-0703-6 |
| 著者 | Mizoo, Taeko| Taira, Naruto| Nishiyama, Keiko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| Ishihara, Setsuko| Kawai, Hiroshi| Kawasaki, Kensuke| Ishibe, Youichi| Ogasawara, Yutaka| Komoike, Yoshifumi| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2013-12-01 |
| 出版物タイトル | BMC Cancer |
| 巻 | 13巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Itoh, Mitsuya| Iwamoto, Takayuki| Matsuoka, Junji| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Niikura, Naoki| Hayashi, Naoki| Ohtani, Shoichiro| Higaki, Kenji| Fujiwara, Toshiyoshi| Doihara, Hiroyoshi| Symmans, W. Fraser| Pusztai, Lajos| |
|---|---|
| 発行日 | 2014-01 |
| 出版物タイトル | Breast Cancer Research and Treatment |
| 巻 | 143巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2012-05 |
| 出版物タイトル | Journal of Cancer Research and Clinical Oncology |
| 巻 | 138巻 |
| 号 | 5号 |
| 資料タイプ | 学術雑誌論文 |
| タイトル（別表記） | Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer |
|---|---|
| フルテキストURL | 126_25.pdf |
| 著者 | 溝尾 妙子| 枝園 忠彦| 伊藤 麻衣子| 野上 智弘| 岩本 高行| 元木 崇之| 平 成人| 松岡 順治| 土井原 博義| |
| 抄録 | Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery. |
| キーワード | OSNA法（OSNA method） センチネルリンパ節（sentinel lymph node） micrometastases CK-19 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2014-04-01 |
| 巻 | 126巻 |
| 号 | 1号 |
| 開始ページ | 25 |
| 終了ページ | 30 |
| ISSN | 0030-1558 |
| 関連URL | http://www.okayama-u.ac.jp/user/oma/ |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2014 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.126.25 |
| 著者 | Nogami, Tomohiro| Shien, Tadahiko| Tanaka, Takehiro| Nishiyama, Keiko| Mizoo, Taeko| Iwamto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2012-03-10 |
| 出版物タイトル | Breast Cancer |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Taira, Naruto| Shimozuma, Kojiro| Shiroiwa, Takeru| Ohsumi, Shozo| Kuroi, Katsumasa| Saji, Shigehira| Saito, Mitsue| Iha, Shigemichi| Watanabe, Takanori| Katsumata, Noriyuki| |
|---|---|
| 発行日 | 2011/08 |
| 出版物タイトル | Breast Cancer Research and Treatment |
| 巻 | 128巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 土井原 博義| 平 成人| |
|---|---|
| 発行日 | 2008-01-04 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 119巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 平 成人| |
|---|---|
| 発行日 | 2006-03-24 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| JaLCDOI | 10.18926/AMO/64356 |
|---|---|
| フルテキストURL | 77_1_11.pdf |
| 著者 | Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| 抄録 | The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction. |
| キーワード | breast reconstruction mastectomy brassiere professional bra fitter |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 11 |
| 終了ページ | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849141 |
| Web of Science KeyUT | 000953663800002 |
| JaLCDOI | 10.18926/AMO/60799 |
|---|---|
| フルテキストURL | 74_5_401.pdf |
| 著者 | Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| |
| 抄録 | Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC. |
| キーワード | differentiated thyroid carcinoma juvenile children |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 401 |
| 終了ページ | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106695 |
| Web of Science KeyUT | 000581970100004 |
| NAID | 120006892925 |
| JaLCDOI | 10.18926/AMO/54607 |
|---|---|
| フルテキストURL | 70_5_425.pdf |
| 著者 | Tamura, Tomoki| Hirata, Taizo| Tabata, Masahiro| Hinotsu, Shiro| Hamada, Akinobu| Motoki, Takayuki| Iwamoto, Takayuki| Mizoo, Taeko| Nogami, Tomohiro| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| |
| 抄録 | Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer. |
| キーワード | breast cancer phase I trial docetaxel |
| Amo Type | Clinical Study Protocols |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-10 |
| 巻 | 70巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 425 |
| 終了ページ | 427 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27777441 |
| Web of Science KeyUT | 000388098700018 |
| JaLCDOI | 10.18926/AMO/53907 |
|---|---|
| フルテキストURL | 69_6_333.pdf |
| 著者 | Ito, Maiko| Shien, Tadahiko| Kaji, Mitsumasa| Mizoo, Taeko| Iwamoto, Takayuki| Nogami, Tomohiro| Motoki, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Miyoshi, Shinichiro| |
| 抄録 | We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (ER)-positive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (>14%) versus low (<14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range:0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p=0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients. |
| キーワード | breast cancer invasive ductal carcinoma 18F-fluorodeoxyglucose positron emission tomography/computed tomography maximum standardized uptake values clinicopathological features |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-12 |
| 巻 | 69巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26690243 |
| Web of Science KeyUT | 000368434500002 |
| JaLCDOI | 10.18926/AMO/50409 |
|---|---|
| フルテキストURL | 67_3_165.pdf |
| 著者 | Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro| |
| 抄録 | While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC. |
| キーワード | breast cancer neoadjuvant chemotherapy predictors |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 165 |
| 終了ページ | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804139 |
| Web of Science KeyUT | Pretreatment Specimen Predicts |