| JaLCDOI | 10.18926/AMO/61215 |
|---|---|
| フルテキストURL | 74_6_545.pdf |
| 著者 | Tatebe, Yasuhisa| Kanamitsu, Kiichiro| Kanzaki, Hirotaka| Ishida, Hisashi| Fujiwara, Kaori| Washio, Kana| Kitamura, Yoshihisa| Sendo, Toshiaki| Shimada, Akira| Tsukahara, Hirokazu| |
| 抄録 | Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner. |
| キーワード | methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-12 |
| 巻 | 74巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 545 |
| 終了ページ | 550 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33361876 |
| Web of Science KeyUT | 000601203600012 |
| NAID | 120006948942 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka| |
| キーワード | Imipramine Carbamazepine ACTH 5-HT2A receptor Forced swim test Wet-dog shakes Treatment–resistant |
| 備考 | Published with permission from the copyright holder. This is a author's copy,as published in Pharmacology Biochemistry and Behavior , 2008, volume 89, issue 3, pp235-240. | |
| 発行日 | 2008-05-20 |
| 出版物タイトル | Pharmacology Biochemistry and Behavior |
| 巻 | 89巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.pbb.2007.12.015 |
| Web of Science KeyUT | 000255311600001 |
| JaLCDOI | 10.18926/AMO/52893 |
|---|---|
| フルテキストURL | 68_5_255.pdf |
| 著者 | Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| 抄録 | Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors. |
| キーワード | motivation reward dopamine operant behavior intracranial self-stimulation |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-10 |
| 巻 | 68巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 255 |
| 終了ページ | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25338481 |
| Web of Science KeyUT | 000343269300001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ushio, Soichiro| Wada, Yudai| Nakamura, Mizuki| Matsumoto, Daiki| Hoshika, Kota| Shiromizu, Shoya| Iwata, Naohiro| Esumi, Satoru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| キーワード | anxiolytic inflammation immunomodulation macrophages Kampo medicine |
| 発行日 | 2022-08-12 |
| 出版物タイトル | Frontiers In Pharmacology |
| 巻 | 13巻 |
| 出版者 | Frontiers Media S.A. |
| 開始ページ | 890048 |
| ISSN | 1663-9812 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Ushio, Wada, Nakamura, Matsumoto, Hoshika, Shiromizu, Iwata, Esumi, Kajizono, Kitamura and Sendo. |
| 論文のバージョン | publisher |
| PubMed ID | 36034871 |
| DOI | 10.3389/fphar.2022.890048 |
| Web of Science KeyUT | 000860773600001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fphar.2022.890048 |