JaLCDOI | 10.18926/AMO/32879 |
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フルテキストURL | fulltext.pdf |
著者 | Umeda, Yuichi| Amano, Manabu| Suemaru, Katsuya| Yamaguchi, Takumi| Kitamura, Yoshihisa| Gomita, Yutaka| Kawasaki, Hiromu| Araki, Hiroaki| |
抄録 | Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-HT2A receptor-mediated wet-dog shake responses in rats treated with adrenocorticotropic hormone (ACTH), dexamethasone and streptozotocin. ACTH (100 μg/rat per day, s.c.), dexamethasone (1 mg/kg per day, s.c.) and streptozotocin (60 mg/kg, i.p.) produced significant hyperglycemia at 14 days after the start of these treatments, and the hyperglycemia was most pronounced in the streptozotocin-treated rats. The wet-dog shake responses induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2A receptor agonist, were significantly enhanced at 14 days after repeated treatment with ACTH and dexamethasone. However, streptozotocin-induced diabetes had no effect on the wet-dog shake responses. The results of the present study suggest that hyperglycemia is not strongly associated with the enhanced susceptibility of 5-HT2A receptors under the condition of hyperactivity of the HPA axis. |
キーワード | hyperglycemia ACTH dexamethasone streptozotocin 5-HT2A receptor |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-12 |
巻 | 61巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 311 |
終了ページ | 317 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 18183075 |
Web of Science KeyUT | 000251943800001 |
JaLCDOI | 10.18926/AMO/40129 |
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フルテキストURL | 64_4_219.pdf |
著者 | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
抄録 | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
キーワード | ACTH imipramine lithium proliferation Ki-67 |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-08 |
巻 | 64巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 219 |
終了ページ | 223 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20802538 |
Web of Science KeyUT | 000281384400002 |