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ID 31331
JaLCDOI
フルテキストURL
著者
Kawakami, Yasuhiro Okayama University
Suemaru, Katsuya Okayama University
Araki, Hiroaki Okayama Univeristy
Kawasaki, Hiromu Okayama University Kaken ID publons
Gomita, Yutaka Okayama University
Tanizaki, Yoshiro Okayama University
抄録

The cross-sensitization to stereotyped behavior between mazindol (MZD) and methamphetamine (MAP) was investigated in rats. MZD (5 and 10 mg/kg/day, p.o.), MAP (5 and 10 mg/kg/day, p.o.) and saline (1 ml/kg, p.o.) were administered once daily for a week. Challenge with MZD (10 mg/kg, p.o.) on the 8th day caused markedly stereotyped behavior in MAP-pretreated group compared with the saline-pretreated control group. MAP (10 mg/kg, p.o.)-induced stereotyped behavior on the 8th day was also greater in MZD-pretreated group rather than the saline-pretreated control group. These results suggest that repeated MZD and MAP administration cross-sensitizes to their stereotype-producing effects.

キーワード
mazindoi
methamphetamine
cross-sensitization
stereotyped behavior
Amo Type
Article
出版物タイトル
Acta Medica Okayama
発行日
1998-06
52巻
3号
出版者
Okayama University Medical School
開始ページ
169
終了ページ
171
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT