岡田裕之

Utility of Combined Use of Transabdominal Ultrasonography and Fecal Immunochemical Test Examinations in Ulcerative Colitis

JaLCDOI	10.18926/AMO/66674
フルテキストURL	78_1_079.pdf
著者	Takahara, Masahiro\| Hiraoka, Sakiko\| Ohmori, Masayasu\| Takeuchi, Keiko\| Takei, Kensuke\| Aoyama, Yuki\| Yasutomi, Eriko\| Igawa, Shoko\| Inokuchi, Toshihiro\| Toyosawa, Junki\| Yamasaki, Yasushi\| Kinugasa, Hideaki\| Harada, Keita\| Onishi, Hideki\| Okada, Hiroyuki\|
抄録	This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful in noninvasive treatment strategies.
キーワード	transabdominal ultrasonography fecal immunochemical test ulcerative colitis Mayo endoscopic subscore
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2024-02
巻	78巻
号	1号
出版者	Okayama University Medical School
開始ページ	79
終了ページ	83
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38419318
Web of Science KeyUT	001203658200004

Oxidative stress-related markers as prognostic factors for patients with primary sclerosing cholangitis in Japan

フルテキストURL	fulltext.pdf
著者	Oyama, Atsushi\| Takaki, Akinobu\| Adachi, Takuya\| Wada, Nozomu\| Takeuchi, Yasuto\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\| Otsuka, Motoyuki\|
キーワード	Primary sclerosing cholangitis Oxidative stress marker Prognosis Serum reactive oxygen metabolite Total serum antioxidant capacity Revised Mayo risk score Child–Pugh score MELD score FIB-4 index Serum dROM Serum OXY-adsorbent test Immunoglobulin A
備考	The version of record of this article, first published in Hepatology International, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12072-023-10557-2\|
発行日	2023-07-26
出版物タイトル	Hepatology International
巻	17巻
号	5号
出版者	Springer Science and Business Media LLC
開始ページ	1215
終了ページ	1224
ISSN	1936-0533
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37493884
DOI	10.1007/s12072-023-10557-2
Web of Science KeyUT	001034200900001
関連URL	isVersionOf https://doi.org/10.1007/s12072-023-10557-2

Diagnostic accuracy of frozen section biopsy for early gastric cancer extent during endoscopic submucosal dissection: a prospective study

フルテキストURL	fulltext.pdf
著者	Kobashi, Mayu\| Ishikawa, Shigenao\| Inaba, Tomoki\| Iwamuro, Masaya\| Aoyama, Yuki\| Kagawa, Tomo\| Takeuchi, Yasuto\| Ando, Midori\| Nakamura, Satoko\| Okada, Hiroyuki\|
キーワード	Frozen section Pathological diagnosis Diagnostic accuracy Early gastric cancer Endoscopic submucosal dissection Lateral margin
備考	The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00464-023-10100-2\|
発行日	2023-05-22
出版物タイトル	Surgical Endoscopy
巻	37巻
号	9号
出版者	Springer Science and Business Media LLC
開始ページ	6736
終了ページ	6748
ISSN	0930-2794
NCID	AA10750363
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37217685
DOI	10.1007/s00464-023-10100-2
Web of Science KeyUT	000993678400007
関連URL	isVersionOf https://doi.org/10.1007/s00464-023-10100-2

Disease Progression-Related Markers for Aged Non-Alcoholic Fatty Liver Disease Patients

JaLCDOI	10.18926/AMO/65748
フルテキストURL	77_4_377.pdf
著者	Morimoto, Kosaku\| Takeuchi, Yasuto\| Takaki, Akinobu\| Wada, Nozomu\| Oyama, Atsushi\| Adachi, Takuya\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
キーワード	NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	377
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635138
Web of Science KeyUT	001163659800009

Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients

JaLCDOI	10.18926/AMO/65740
フルテキストURL	77_4_347.pdf
著者	Iwamuro, Masaya\| Kondo, Takumi\| Ennishi, Daisuke\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Takahashi, Takahide\| Hirabata, Araki\| Tanaka, Takehiro\| Otsuka, Fumio\| Maeda, Yoshinobu\| Okada, Hiroyuki\|
抄録	The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
キーワード	flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	347
終了ページ	357
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635134
Web of Science KeyUT	001163659800002

Low Patient Weight and Long Intubation Time Are Key Factors for Pain during Colonoscopy

JaLCDOI	10.18926/AMO/65969
フルテキストURL	77_5_471.pdf
著者	Oka, Shohei\| Harada, Keita\| Yamamoto, Shumpei\| Yasutomi, Eriko\| Igawa, Shoko\| Ohmori, Masayasu\| Hirai, Mami\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Takahara, Masahiro\| Hiraoka, Sakiko\| Okada, Hiroyuki\|
抄録	Although the clinical usefulness of colonoscopy has been established, the procedure remains painful for many patients. This study was designed to clarify the factors predicting colonoscopy-related pain. We evaluated 283 consecutive patients who completed a first-ever, total colonoscopy without sedatives or analgesics. The severity of pain symptoms was evaluated by a numeric rating scale (NRS) in a questionnaire immediately after the colonoscopy. Patient backgrounds and endoscopic findings were analyzed to evaluate their association with pain. Out of 283 patients, 53 scored their pain 0-1 on the NRS while 48 scored it 6-10. We defined the colonoscopies of the former and latter patients as painless and painful, respectively, and compared the two. Multivariate analyses revealed that low body weight (OR 4.95, 95%CI 1.89-12.99) and longer intubation time (OR 3.63, 95%CI 1.46-9.03) were significant risk factors for painful colonoscopy. To identify factors contributing to the increased intubation time, we divided subjects into short- and long-intubation-time groups based on a median insertion time of 7 min. Older age (OR 2.28, 95%CI 1.31-3.98), previous abdominal surgery (OR 1.93, 95%CI 1.13-3.32) and findings of invasive cancer (OR 10.90, 95%CI 1.34-88.90) were significant factors for longer intubation time.
キーワード	colonoscopy colonoscopy-related pain comfortable colonoscopy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	471
終了ページ	478
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899258
Web of Science KeyUT	001108661600004

Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure

フルテキストURL	fulltext.pdf
著者	Kikuchi, Tatsuya\| Kono, Yoshiyasu\| Nakagawa, Koji\| Okada, Hiroyuki\| Miyamoto, Masakazu\| Takaya, Yoichi\| Hirata, Shoichiro\| Inoo, Shoko\| Kuraoka, Sakiko\| Okanoue, Shotaro\| Matsueda, Katsunori\| Satomi, Takuya\| Hamada, Kenta\| Iwamuro, Masaya\| Kawano, Seiji\| Kawahara, Yoshiro\|
キーワード	antithrombotic drugs gastrointestinal bleeding left atrial appendage closure
発行日	2023-12-27
出版物タイトル	JGH Open
巻	8巻
号	1号
出版者	Wiley
開始ページ	e13009
ISSN	2397-9070
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
DOI	10.1002/jgh3.13009
Web of Science KeyUT	001131741800001
関連URL	isVersionOf https://doi.org/10.1002/jgh3.13009

MicroRNA-451a inhibits gemcitabine-refractory biliary tract cancer progression by suppressing the MIF-mediated PI3K/AKT pathway

フルテキストURL	fulltext.pdf
著者	Obata, Taisuke\| Tsutsumi, Koichiro\| Ueta, Eijiro\| Oda, Takashi\| Kikuchi, Tatsuya\| Ako, Soichiro\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Kato, Hironari\| Okada, Hiroyuki\| Otsuka, Motoyuki\|
発行日	2023-12-12
出版物タイトル	Molecular Therapy Nucleic Acids
巻	34巻
出版者	Cell Press
開始ページ	102054
ISSN	2162-2531
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Author(s).
論文のバージョン	publisher
PubMed ID	38111913
DOI	10.1016/j.omtn.2023.102054
Web of Science KeyUT	001146413100001
関連URL	isVersionOf https://doi.org/10.1016/j.omtn.2023.102054

Berberine improved experimental chronic colitis by regulating interferon-gamma- and IL-17A-producing lamina propria CD4(+) T cells through AMPK activation

フルテキストURL	SR9_1_11934.pdf
著者	Takahara, Masahiro\| Takaki, Akinobu\| Hiraoka, Sakiko\| Adach, Takuya\| Shimomura, Yasuyuki\| Matsushita, Hiroshi\| Nguyen Tien Thi Thuy\| Koike, Kazuko\| Ikeda, Airi\| Takashima, Shiho\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Sugihara, Yusaku\| Harada, Keita\| Eikawa, Shingo\| Morita, Hidetoshi\| Udono, Heiichiro\| Okada, Hiroyuki\|
発行日	2019-8-15
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	11934
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	31417110
DOI	10.1038/s41598-019-48331-w
Web of Science KeyUT	000480680800048
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-48331-w

Resection depth for small colorectal polyps comparing cold snare polypectomy, hot snare polypectomy and underwater endoscopic mucosal resection

フルテキストURL	fulltext.pdf
著者	Toyosawa, Junki\| Yamasaki, Yasushi\| Fujimoto, Tsuyoshi\| Tanaka, Shouichi\| Tanaka, Takehiro\| Mitsuhashi, Toshiharu\| Okada, Hiroyuki\|
発行日	2022-05-13
出版物タイトル	Endoscopy International Open
巻	10巻
号	05号
出版者	Georg Thieme Verlag KG
開始ページ	E602
終了ページ	E608
ISSN	2364-3722
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022. The Author(s).
論文のバージョン	publisher
PubMed ID	35571476
DOI	10.1055/a-1785-8616
Web of Science KeyUT	000794976400009
関連URL	isVersionOf https://doi.org/10.1055/a-1785-8616

Modified line-assisted complete closure of the defect after gastric endoscopic full-thickness resection: a pilot study in porcine models

フルテキストURL	fulltext.pdf
著者	Yamasaki, Yasushi\| Ohmori, Masayasu\| Toyosawa, Junki\| Ako, Soichiro\| Okada, Hiroyuki\|
発行日	2022-05-13
出版物タイトル	Endoscopy International Open
巻	10巻
号	05号
出版者	Georg Thieme Verlag KG
開始ページ	E609
終了ページ	E615
ISSN	2364-3722
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022. The Author(s).
論文のバージョン	publisher
PubMed ID	35571472
DOI	10.1055/a-1785-8589
Web of Science KeyUT	000794976400010
関連URL	isVersionOf https://doi.org/10.1055/a-1785-8589

Comparison of Bilateral and Trisegment Drainage in Patients with High-Grade Hilar Malignant Biliary Obstruction: A Multicenter Retrospective Study

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Kato, Hironari\| Morimoto, Kosaku\| Miyamoto, Kazuya\| Saragai, Yosuke\| Kawamoto, Hirofumi\| Okada, Hiroyuki\|
キーワード	Bile duct obstruction Neoplasms Endoscopic biliary drainage Bilateral drainage Self-expandable metallic stents
発行日	2022-07-19
出版物タイトル	Gut and Liver
巻	17巻
号	1号
出版者	The Editorial Office of Gut and Liver
開始ページ	170
終了ページ	178
ISSN	1976-2283
NCID	AA12329814
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Gut and Liver.
論文のバージョン	publisher
PubMed ID	35851039
DOI	10.5009/gnl220012
Web of Science KeyUT	000830704600001
関連URL	isVersionOf https://doi.org/10.5009/gnl220012

Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Kato, Hironari\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
キーワード	Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry
備考	The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6\|
発行日	2022-02-08
出版物タイトル	Journal of Gastrointestinal Surgery
巻	26巻
号	6号
出版者	Springer Science and Business Media LLC
開始ページ	1213
終了ページ	1223
ISSN	1091-255X
NCID	AA11494553
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35137343
DOI	10.1007/s11605-021-05197-6
Web of Science KeyUT	000752761400001
関連URL	isVersionOf https://doi.org/10.1007/s11605-021-05197-6

Fever and electrocoagulation syndrome after colorectal endoscopic submucosal dissection for patients with immunosuppressants and steroids

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shumpei\| Kinugasa, Hideaki\| Yamasaki, Yasushi\| Hirai, Mami\| Ako, Soichiro\| Takei, Kensuke\| Igawa, Shoko\| Yasutomi, Eriko\| Oka, Shohei\| Ohmori, Masayasu\| Inokuchi, Toshihiro\| Harada, Keita\| Hiraoka, Sakiko\| Nouso, Kazuhiro\| Tanaka, Takehiro\| Okada, Hiroyuki\|
キーワード	colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever
発行日	2021-12-09
出版物タイトル	DEN Open
巻	2巻
号	1号
出版者	Wiley
開始ページ	e83
ISSN	2692-4609
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	35310725
DOI	10.1002/deo2.83
Web of Science KeyUT	001047024900091
関連URL	isVersionOf https://doi.org/10.1002/deo2.83

Recent advances regarding endoscopic biliary drainage for unresectable malignant hilar biliary obstruction

フルテキストURL	fulltext.pdf
著者	Kato, Hironari\| Matsumoto, Kazuyuki\| Okada, Hiroyuki\|
キーワード	biliary drainage EUS-BD malignant hilar biliary obstruction side-by-side stent-in-stent
発行日	2021-09-07
出版物タイトル	DEN Open
巻	2巻
号	1号
出版者	Wiley
開始ページ	e33
ISSN	2692-4609
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	35310763
DOI	10.1002/deo2.33
Web of Science KeyUT	001047024900042
関連URL	isVersionOf https://doi.org/10.1002/deo2.33

Prospective multicenter study of the efficacy and safety of cold forceps polypectomy for ≤ 6-mm non-ampullary duodenal low-grade adenomas

フルテキストURL	fulltext.pdf
著者	Kanzaki, Hiromitsu\| Horii, Joichiro\| Takenaka, Ryuta\| Nakagawa, Hiroyuki\| Matsueda, Kazuhiro\| Tsuzuki, Takao\| Kita, Masahide\| Yamasaki, Yasushi\| Tanaka, Takehiro\| Iwamuro, Masaya\| Kawano, Seiji\| Kawahara, Yoshiro\| Tomoda, Jun\| Okada, Hiroyuki\|
発行日	2022-06-10
出版物タイトル	Endoscopy International Open
巻	10巻
号	06号
出版者	Georg Thieme Verlag KG
開始ページ	E712
終了ページ	E718
ISSN	2364-3722
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022. The Author(s).
論文のバージョン	publisher
PubMed ID	35859656
DOI	10.1055/a-1793-9439
Web of Science KeyUT	000826506700001
関連URL	isVersionOf https://doi.org/10.1055/a-1793-9439

Postoperative Bleeding Risk after Gastric Endoscopic Submucosal Dissection in Patients Receiving a P2Y12 Receptor Antagonist

フルテキストURL	fulltext.pdf
著者	Hirai, Ryosuke\| Kawano, Seiji\| Inoo, Shoko\| Kuraoka, Sakiko\| Okanoue, Shotaro\| Satomi, Takuya\| Hamada, Kenta\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Iwamuro, Masaya\| Kawahara, Yoshiro\| Okada, Hiroyuki\|
キーワード	Fibrinolytic agents Endoscopic submucosal resection Postoperative hemorrhage Purinergic P2Y receptor antagonists
発行日	2022-09-29
出版物タイトル	Gut and Liver
巻	17巻
号	3号
出版者	The Editorial Office of Gut and Liver
開始ページ	404
終了ページ	411
ISSN	1976-2283
NCID	AA12329814
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Gut and Liver.
論文のバージョン	publisher
PubMed ID	36172713
DOI	10.5009/gnl220196
Web of Science KeyUT	000869939200001
関連URL	isVersionOf https://doi.org/10.5009/gnl220196

A Comparison of the Efficacy of Plastic Stent Placement Above and Across the Sphincter of Oddi for Benign Biliary Hilar Stricture

JaLCDOI	10.18926/AMO/65494
フルテキストURL	77_3_291.pdf
著者	Himei, Hitomi\| Kato, Hironari\| Saragai, Yosuke\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Okada, Hiroyuki\|
抄録	We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal.
キーワード	benign biliary stricture inside stent plastic stent
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	299
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357630
Web of Science KeyUT	001026279600007

Endocrinological Changes after Anamorelin Administration in Patients with Gastrointestinal Cancer

JaLCDOI	10.18926/AMO/65488
フルテキストURL	77_3_235.pdf
著者	Kuraoka, Sakiko\| Iwamuro, Masaya\| Satomi, Takuya\| Yamazaki, Tatsuhiro\| Hamada, Kenta\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Kato, Hironari\| Otsuka, Fumio\| Okada, Hiroyuki\|
抄録	Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ΔIGF-1 SD score and Δthyroidstimulating hormone (TSH) and between ΔIGF-1 SD score and Δfree testosterone. ΔBody weight and ΔIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (≥ 12 weeks) users.
キーワード	anamorelin body weight cancer cachexia endocrine system
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	235
終了ページ	241
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357624
Web of Science KeyUT	001026279600001

Incidence of Serious Upper Gastrointestinal Bleeding in Patients Taking Non-steroidal Anti-infl ammatory Drugs in Japan

JaLCDOI	10.18926/AMO/30992
フルテキストURL	fulltext.pdf
著者	Ishikawa, Shigenao\| Inaba, Tomoki\| Mizuno, Motowo\| Okada, Hiroyuki\| Kuwaki, Kenji\| Kuzume, Toshiaki\| Yokota, Hitomi\| Fukuda, Yasuyo\| Takeda, Kou\| Nagano, Hiroshi\| Wato, Masaki\| Kawai, Kozo\|
抄録	Upper gastrointestinal bleeding is a major adverse event of non-steroidal anti-inflammatory drugs (NSAIDs), and co-administration of proton pump inhibitors and H2 receptor antagonists has been established as a means of preventing such an eff ect. However, the incidence of bleeding associated with NSAID-induced ulcers under conditions where such strong anti-acid agents are used for prevention has yet to be clarified. We aimed to determine the annual incidence of serious upper gastrointestinal ulcer bleeding among Japanese patients in whom NSAIDs were used in our hospital. Before commencing the study, we recommended to all the physicians in our hospital the best method for caring for NSAID users, focusing on the concomitant use of proton pump inhibitors or H2 receptor antagonists. We conducted a cohort study involving 17,270 patients for whom NSAIDs had been newly prescribed. Bleeding from gastric ulcers was observed in 8 of the 17,270 patients using NSAIDs (0.05%). The pooled incidence rate for bleeding was calculated as 2.65 (95% confidence interval, 2.56-2.74) and 1.29 (1.27-1.31) per 1,000 patient years for low-dose aspirin and non-aspirin NSAID users, respectively. None of the bleeding ulcer patients required blood transfusion or were in serious condition. In conclusion, gastric ulcer bleeding occurred in low-dose aspirin or non-aspirin NSAID users, but its incidence was low and outcomes were not serious when adequate preventive measures were taken.
キーワード	hemorrhage non-steroidal anti-inflammatory drugs peptic ulcer prevention
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2008-02
巻	62巻
号	1号
出版者	Okayama University Medical School
開始ページ	29
終了ページ	36
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
論文のバージョン	publisher
査読	有り
PubMed ID	18323869
Web of Science KeyUT	000253549500005

岡田 裕之