ID | 18218 |
Eprint ID | 18218
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フルテキストURL | |
タイトル(別表記) | Studies on Chemotherapy in the Antituberculous Drug-resistant Tuberculosis Part Ⅱ. Comperative Studies of the Effectiveness of Kanamycin, Cycloserine and Ethionamide Treatment
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著者 |
河西 浩一
岡山大学医学部平木内科教室
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抄録 | Experimental tuberculosis in mice infected with cultures of the H(37)Rv strain exhibiting high degrees of resistance to SM, PAS and INH and subsequently treated with single administration of KM, CS and TH respectively was carried out, Also a clinical observation of reversal of infectiousness of the tubercle bacilli of the sputum of patients with chronic pulmonary tuberculosis by this treatment regime was performed. Kanamycin treatment of 1mg per mouce scarcely showed the effectiveness to all of the resistant strains. Cycloserine treatment of 2.5mg per mouce did not show any improvement of the tuberculous lesions. It is assumed that many inactive factors to CS in mouse body take part in this uneffectiveness of CS, but especially the activity of D-alanine does, While, ethionamide treatment of 1mg per mouce revealed marked effectiveness to each resistant strain and it is noted that TH treatment of 1mg per mouce was as effective as INH treatment of 0.1mg per mouce. In the clinical observation, single administration of KM, CS or TH revealed no remarkable effectiveness to the patients with triple resistant tubercle bacilli to SM, PAS anp INH. Especially this treatment regime to the patients with chronic far advanced, active pulmonary tuberculosis scarcely brought reversal of infectiousness. It may be concluded that the single administration of TH should not be done because of easy appearence of the resistance in short time.
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発行日 | 1965-02-28
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 77巻
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号 | 2号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 415
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終了ページ | 428
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/77/2/77_2_415/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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