ID | 66939 |
フルテキストURL | |
著者 |
Kobashi, Mayu
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ishikawa, Shigenao
Department of Gastroenterology, Kagawa Prefectural Central Hospital
Inaba, Tomoki
Department of Gastroenterology, Kagawa Prefectural Central Hospital
Iwamuro, Masaya
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Aoyama, Yuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kagawa, Tomo
Department of Gastroenterology, Kagawa Prefectural Central Hospital
Takeuchi, Yasuto
Department of Regenerative Medicine, Center for Innovative Clinical Medicine, Okayama University Hospital
Ando, Midori
Department of Pathology, Kagawa Prefectural Central Hospital
Nakamura, Satoko
Department of Pathology, Kagawa Prefectural Central Hospital
Okada, Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kaken ID
publons
researchmap
|
抄録 | Background Accurate diagnosis of the lateral extent of early gastric cancer during endoscopic submucosal dissection (ESD) is crucial to achieve negative resection margins. Similar to intraoperative consultation with a frozen section in surgery, rapid frozen section diagnosis with endoscopic forceps biopsy may be useful in assessing tumor margins during ESD. This study aimed to evaluate the diagnostic accuracy of frozen section biopsy.
Methods We prospectively enrolled 32 patients undergoing ESD for early gastric cancer. Biopsy samples for the frozen sections were randomly collected from fresh resected ESD specimens before formalin fixation. Two different pathologists independently diagnosed 130 frozen sections as “neoplasia,” “negative for neoplasia,” or “indefinite for neoplasia,” and the frozen section diagnosis was compared with the final pathological results of the ESD specimens. Results Among the 130 frozen sections, 35 were from cancerous areas, and 95 were from non-cancerous areas. The diagnostic accuracies of the frozen section biopsies by the two pathologists were 98.5 and 94.6%, respectively. Cohen’s kappa coefficient of diagnoses by the two pathologists was 0.851 (95% confidence interval: 0.837–0.864). Incorrect diagnoses resulted from freezing artifacts, a small volume of tissue, inflammation, the presence of well-differentiated adenocarcinoma with mild nuclear atypia, and/or tissue damage during ESD. Conclusions Pathological diagnosis of frozen section biopsy is reliable and can be applied as a rapid frozen section diagnosis for evaluating the lateral margins of early gastric cancer during ESD. |
キーワード | Frozen section
Pathological diagnosis
Diagnostic accuracy
Early gastric cancer
Endoscopic submucosal dissection
Lateral margin
|
備考 | The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00464-023-10100-2
|
発行日 | 2023-05-22
|
出版物タイトル |
Surgical Endoscopy
|
巻 | 37巻
|
号 | 9号
|
出版者 | Springer Science and Business Media LLC
|
開始ページ | 6736
|
終了ページ | 6748
|
ISSN | 0930-2794
|
NCID | AA10750363
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © The Author(s) 2023
|
論文のバージョン | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1007/s00464-023-10100-2
|
ライセンス | http://creativecommons.org/licenses/by/4.0/
|
Citation | Kobashi, M., Ishikawa, S., Inaba, T. et al. Diagnostic accuracy of frozen section biopsy for early gastric cancer extent during endoscopic submucosal dissection: a prospective study. Surg Endosc 37, 6736–6748 (2023). https://doi.org/10.1007/s00464-023-10100-2
|
助成機関名 |
Okayama University
|