ID | 66921 |
フルテキストURL | |
著者 |
Ohsawa, Kumiko
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Momose, Shuji
Department of Pathology, Saitama Medical Center, Saitama Medical University
Nishikori, Asami
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Nishimura, Midori Filiz
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Gion, Yuka
Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences
Sawada, Keisuke
Department of Pathology, Saitama Medical Center, Saitama Medical University
Higashi, Morihiro
Department of Pathology, Saitama Medical Center, Saitama Medical University
Tokuhira, Michihide
Department of Hematology, Japan Community Health Care Organization Saitama Medical Center
Tamaru, Jun-Ichi
Department of Pathology, Saitama Medical Center, Saitama Medical University
Sato, Yasuharu
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
ORCID
Kaken ID
researchmap
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抄録 | A subset of patients with rheumatoid arthritis receiving methotrexate develop immune deficiencies and dysregulation-associated lymphoproliferative disorders. Patients with these disorders often exhibit spontaneous regression after MTX withdrawal; however, chemotherapeutic intervention is frequently required in patients with classic Hodgkin lymphoma arising in immune deficiency/dysregulation. In this study, we examined PD-L1 expression levels and 9p24.1 copy number alterations in 27 patients with classic Hodgkin lymphoma arising from immune deficiency/dysregulation. All patients demonstrated PD-L1 protein expression and harbored 9p24.1 copy number alterations on the tumor cells. When comparing clinicopathological data and associations with 9p24.1 copy number features, the copy gain group showed a significantly higher incidence of extranodal lesions and clinical stages than the amplification group. Notably, all cases in the amplification group had latency type II, while 6/8 (75%) in the copy gain group had latency type II, and 2/8 (25%) had latency type I. Thus, a subset of the copy-gain group demonstrated more extensive extranodal lesions and higher clinical stages. This finding speculates the presence of a genetically distinct subgroup within the group of patients who develop immune deficiencies and dysregulation-associated lymphoproliferative disorders, which may explain certain characteristic features.
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キーワード | classic Hodgkin lymphoma
methotrexate
immunodeficiency
programmed cell death-ligand 1
rheumatoid arthritis
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発行日 | 2024-03-27
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出版物タイトル |
Cancers
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巻 | 16巻
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号 | 7号
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出版者 | MDPI
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開始ページ | 1298
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ISSN | 2072-6694
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2024 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/cancers16071298
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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Citation | Ohsawa, K.; Momose, S.; Nishikori, A.; Nishimura, M.F.; Gion, Y.; Sawada, K.; Higashi, M.; Tokuhira, M.; Tamaru, J.-i.; Sato, Y. Copy Number Analysis of 9p24.1 in Classic Hodgkin Lymphoma Arising in Immune Deficiency/Dysregulation. Cancers 2024, 16, 1298. https://doi.org/10.3390/cancers16071298
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