JaLCDOI 10.18926/14950
タイトル(別表記) Clinical significance of spa therapy in the treatmentof patients with chronic obstructive pulmonary disease (COPD). A study on 511 patients with COPD admitted for last 5 years
フルテキストURL 069_001_008.pdf
著者 谷崎 勝朗| 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 湯本 英一郎| 高田 真吾| 越智 浩二| 原田 英雄|
抄録 1993年1月より1997年12月までの5ヵ年間に当院へ入院した慢性閉塞性呼吸器疾患511例を対象に,疾患の種類,年齢,地域分布などについて検討を加えた。1.最近5年間に当院へ入院した呼吸器疾患患者は594例で,このうち,慢性閉塞性呼吸器疾患患者は511例(86.0%)であった。これらの慢性閉塞性呼吸器疾患のなかでは,気管支喘息が416例(81.4%)と最も多く,その他.慢性気管支炎20例,閉塞性細気管支炎27例,肺気腫48例であった。2.慢性閉塞性呼吸器疾患のなかでは,肺気腫の症例が増加する傾向が見られた。3.慢性閉塞性呼吸器疾患の年齢別検討では,鳥取県内では,70才以上の症例が,また遠隔地(鳥取県外)では60-69才の症例の頻度が高い傾向が見られた。4.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,その比率は1997年度で48.4%であった。また,その分布別検討では,岡山県,兵庫県,大阪府,広島県,山口県,愛媛県からの入院患者が多い傾向が見られた。
キーワード 慢性閉塞性呼吸器疾患 (COPD) 気管支喘息 (bronchial asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area)
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 1
終了ページ 8
ISSN 0918-7839
言語 日本語
論文のバージョン publisher
NAID 120002308114
JaLCDOI 10.18926/14951
タイトル(別表記) 気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生能
フルテキストURL 069_009_014.pdf
著者 谷崎 勝朗| 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 湯本 英一郎| 高田 真吾| 越智 浩二| 原田 英雄|
抄録 The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 16 patients with asthma (8 with atopic and 8 with nonatopic asthma) and 12 healthy controls. 1. The LT84 generation by leucocytes was not significantly different between patients with asthma and healthy controls. The generation of LTC4 was significantly larger in patients with asthma than in healthy controls. The LTC4 generation was also significantly larger in patients with attacks (58.4 ± 38.5 ng/5x10(6) cells) than in those without attacks (23.3 ± 25.9 ng/5x10(6) cells)(p<0.05). 2.ln atopic asthma, the LTC4 production was significantly larger in patients with attacks (84.7 ± 35.4 ng/5x10(6) cells) compared to the production in those without attacks (40.4 ± 27.2 ng/5x10(6) cells)(p<0.02). However, the production of LTB4 was not significantly different between attack and attack-free stages. 3. In nonatopic asthma, the LTC4 production was also significantly higher in patients with attacks (32.2 ± 26.3 ng/5x10(6) cells) than in those without attacks (12.2 ± 3.5 ng/5x10(6) cells)(p<0.05). However, the LTB4 production was not significantly different between attack and nonattack stages. 4. The LTC4 production was significantly larger in atopic asthmatics compared to the production in nonatopic subjects both in attack and nonattack stages. These results suggest that the generation of LTC4 by leucocytes of patients with asthma is closely related to IgE-mediated reaction and asthma attacks.
キーワード bronchial asthma LTB4 LTC4 IgE-mediated reaction asthma attacks
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 9
終了ページ 14
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308181
JaLCDOI 10.18926/14953
タイトル(別表記) 肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連
フルテキストURL 069_015_020.pdf
著者 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 湯本 英一郎| 高田 真吾| 越智 浩二| 原田 英雄| 長谷川 晴巳|
抄録 The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease.
キーワード emphysema mean CT number LTB4 LTC4
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 15
終了ページ 20
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308094
JaLCDOI 10.18926/14954
タイトル(別表記) 肺気腫患者における吸入抗原に対するIgE抗体
フルテキストURL 069_021_027.pdf
著者 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 湯本 英一郎| 高田 真吾| 谷崎 勝朗| 越智 浩二| 原田 英雄| 長谷川 晴巳|
抄録 To analyze the pathophysiological changes ot the airways in emphysema, bronchial responsiveness and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leucocytes were examined in 22 patients with emphysema. The subjects were divided into two groups according to the presence or absence of IgE antibodies against inhalant allergens; RAST positive group and RAST negative group. 1. Smoking history, mean CT number and mean maximum % low attenuation area (% LAA) <-950HU of the lung on high resolution computed tomography (HRCT), and DLco value suggested that there were emphysematous changes of the lung in all subjects. However, these findings were not different between the two groups. 2. The level of serum IgE was significantly higher in RAST positive group than in RAST negative group. 3. The mean % increase in FEV1.0 after inhalation of β-agonists was higher in RAST positive group than in RAST negative group. The % increase more than 15% was found in 4 of the 9 subjects (44.4%) in RAST positive group and 2 of the 12 (16.7%) in RAST negative group. 4. The generation of LTC4 by leucocytes was significantly higher in RAST positive group than in RAST negative group (p<0.01). The generation of LTB4 was not significantly different between the two groups. The results suggest that IgE-mediated allergy participates in the bronchial responsiveness of patients with emphysema.
キーワード emphysema bronchial responsiveness FEV1.0 LTB4 LTC4
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 21
終了ページ 27
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308178
JaLCDOI 10.18926/14955
タイトル(別表記) 気管支喘息患者における努力肺活量(% FVC)の低下と気道炎症ならびに臨床病型との関連
フルテキストURL 069_028_034.pdf
著者 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 横田 聡| 柘野 浩史| 谷崎 勝朗| 越智 浩二| 原田 英雄|
抄録 Clinical features of asthmatics with a low % FVC (<80%) were studied in relation to airway inflammation and clinical asthma types. 1. Twenty four (75.0%) of the 32 subjects with a low % FVC had steroid-dependent intractable asthma. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type II asthma (bronchiolar obstruction), in which significantly decreased proportion of lymphocytes,and significantly increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid were observed, than in those with type la-1 (simple bronchoconstriction) with (P<0.001) and without glucocorticoid therapy (P<0.02). 3. The % FVC value was significantly improved after treatment in type lb (hypersecretion) with BAL eosinophilia, but not in those with type II with BAL neutrophilia. These results demonstrate that marked decrease of % FVC in patients with asthma correlated with airway inflammation, and that airway reversibility by medication is very low in patients with type II asthma.
キーワード ventilatory function FEV1.0 bronchoalveolar lavage bronchial reversibility
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 28
終了ページ 34
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308252
JaLCDOI 10.18926/14956
タイトル(別表記) MR-angiographyで経過を観察しえた慢性関節リウマチに合併した巨細胞動脈炎の1例
フルテキストURL 069_035_039.pdf
著者 原田 誠之| 光延 文裕| 兒玉 富美子| 保崎 泰弘| 御舩 尚志| 柘野 浩史| 岡本 誠| 湯本 英一朗| 高田 真吾| 谷崎 勝朗|
抄録 We report a patient who developed giant cell (temporal) arteritis during treatment of rheumatoid arthritis. The patient was a 57-year-old Japanese woman and had been well controlled with anti-rheumatic drugs, when she presented to our hospital with severe bitemporal headaches and marked fatigue. An exclusive diagnosis was rapidly made and she was diagnosed as having giant cell arteritis based on the classification criteria by American College of Reumatology. Additionally, magnetic resonance (MR) angiography was performed, from which stenotic change in the bilateral superficial temporal arteries was strongly suspected and then corticosteroid therapy was quickly started. The patient followed an uneventful course without developing any complications such as visual dysfunctions. Therapeutic effect was confirmed by MR-angiographic findings obtained 4 weeks after the initiation of therapy.
キーワード 巨細胞動脈炎 (giant cell arteritis) 側頭動脈炎 (temporal arteritis) 慢性関節リウマチ (rheumatoid arthritis) MRアンギオグラフィー (MR-angiography)
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 35
終了ページ 39
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308121
JaLCDOI 10.18926/14959
タイトル(別表記) n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較
フルテキストURL 069_040_048.pdf
著者 岡本 誠| 芦田 耕三| 光延 文裕| 御舩 尚志| 保崎 泰弘| 柘野 浩史| 原田 誠之| 湯本 英一朗| 高田 真吾| 谷崎 勝朗| 片岡 幹男| 原田 実根|
抄録 N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation.
キーワード n-3系脂肪酸 (n-3 fatty acids) エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) LTB4 LTC4
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 40
終了ページ 48
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308199
JaLCDOI 10.18926/14960
タイトル(別表記) n-3系脂肪散を強化した食事療法が有効と考えられた肺気腫の一例
フルテキストURL 069_049_056.pdf
著者 柘野 浩史| 芦田 耕三| 光延 文裕| 御舩 尚志| 岡本 誠| 保崎 泰弘| 谷崎 勝朗| 辻 孝夫|
抄録 An effective treatment for the advanced stages of chronic obstructive pulmonary disease (COPD) has not been established yet. We report our recent experience of one patient with pulmonary emphysema treated by dietary supplementation of n-3 fatty acid for two months. He presented improvements in clinical symptoms and pulmonary function, and suppression of leukotriene B(4) generation by peripheral leukocytes. We consequently suppose that dietary treatment with n-3 fatty acids (perilla seed oil) may offer benefits for the treatment of pulmonary emphysema by competitively inhiabiting the conversion of arachidonicacid to leukotrienes and prostanoids.
キーワード pulmonary emphysema n-3 fatty acid leukotriene diet therapy
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 49
終了ページ 56
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308253
JaLCDOI 10.18926/14961
タイトル(別表記) 鼻腔・副鼻腔疾患を合併する気管支喘息症例に対するクラリスロマイシン投与の効果
フルテキストURL 069_057_062.pdf
著者 御舩 尚志| 光延 文裕| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 原田 誠之| 岡本 誠| 湯本 英一朗| 高田 真吾| 谷崎 勝朗|
抄録 We experienced a case of 59-year-old woman with intractable asthma, who had aspirin intolerance. Despite various treatments including systemic corticosteroid administration, she was often admitted due to severe asthma attacks. Furthermore, she had allergic rhinitis and sinusitis. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa and air-fluid level in maxillary sinuses. Although her asthma symptoms such as wheezing and dyspnea were improved by administration of bronchodilator, systemic corticosteroids and beclomethasone diisoccyanate (BDI) accompanied with spa therapy, her peak expiratory flow (PEF) showed no improvement. After readmission due to asthma attacks, clarithromycin (CAM) administration for sinonasal disorders was started. The PEF value showed marked improvement after starting CAM administration, and pulmonary functions and bronchial hyperresponsiveness were also improved. It is suggested from her clinical course that CAM may have beneficial effects in asthmatic patients with sinonasal disorders.
キーワード bronchial asthma allergic rhinitis sinusitis clarithromycin peak expiratory flow (PEF)
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 57
終了ページ 62
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308388
JaLCDOI 10.18926/14962
タイトル(別表記) ステロイド依存性重症難治性気管支喘息症例における胃粘膜病変の検討
フルテキストURL 069_063_067.pdf
著者 御舩 尚志| 光延 文裕| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 原田 誠之| 岡本 誠| 湯本 英一朗| 高田 真吾| 谷崎 勝朗|
抄録 Recently, we experienced two asthmatic patients with advanced gastric cancer. The two patients had steroid-dependent intractable asthma (SDIA) who had been on administration of corticosteroids for more than 2 years. To determine the influence of pathophysiology of SDIA on stomach mucous lesion, gastroscopic examinations and immunological examinations were performed in eight patients with SDIA, compared with 25 patient with non-SDIA. In patients with SDIA, gastric cancer, its precursor condition and immunosuppressive state were observed. These results suggest that the immunosuppressive state in SDIA induced by the long-term administration of corticosteroids may lead to the risk of gastric cancer development.
キーワード ステロイド依存性重症難治性 (steroid-dependent intractable asthma (SDIA)) 胃癌 (gastric cancer) 免疫抑制 (immunosuppression) リンパ球 (lymphocytes) IgG
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 63
終了ページ 67
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308665
JaLCDOI 10.18926/14963
タイトル(別表記) サーモグラフィーによる体表面温度の測定 2.温水負荷の効果
フルテキストURL 069_068_075.pdf
著者 保崎 泰弘| 高田 真吾| 光延 文裕| 御舩 尚志| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 谷崎 勝朗| 越智 浩二| 原田 英雄| 辻 孝夫|
抄録 The body surface temperature of 41 patients suffering coldness, numbness or pain in their feet was examined using thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as: Recovery ratio =[Total counts of thermography (Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). Three different baseline temperatures, 26℃. 27℃ and 28℃, were used in processing the thermographic results into pictures. The recovery ratio was susceptible to temperature, and we recommend a baseline temperature limitation of 27℃ for clinical study. A bi-modal distribution of recovery ratio was observed in 18 patients with diabetes mellitus. One group (6 subjects) had high recovery ratio between 80%-100%, and another group (10 subjects) had a low recovery ratio between 0%-19%. The results of thermography were also influenced by weather. To reduce the effect of outside temperature, we used pre-loading with hot water at 36℃ for 5 min (hot loading). A large difference in recovery ratio between presence and absence of hot loading was observed in 6 of the 30 subjects. The difference was over-estimated in more than 20% of recovery ratio without hot loading as compared with hot loading in these 6 subjects. The effect of drugs on peripheral circulation, such as beraprost sodium and sarpogrelate hydrochloride, was clear and quantified using thermography under these conditions of hot loading.
キーワード サーモグラフィー (thermography) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) 温水負荷 (hot loading)
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 68
終了ページ 75
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308316
JaLCDOI 10.18926/14964
タイトル(別表記) The effects of perilla seed oil ointment for atopic dermatitis
フルテキストURL 069_076_081.pdf
著者 宮本 美由紀| 穐山 千晶| 能見 美智代| 高田 純子| 西村 伸子| 中村 寿美江| 川上 恭弘| 岡本 誠| 芦田 耕三| 光延 文裕| 谷崎 勝朗|
抄録 近年アトピー性皮膚炎が増加しており,工ゴマ油を使った食事療法がアレルギー抑制に有用であることが報告されている。そこで今回,エゴマ油を外用剤として使用するため,亜鉛華単軟膏を基剤とした工コマ軟膏を作製し,アトピー性皮膚炎患者3例を対象にその臨床応用を試みた。その結果,掻痒感の軽減に効果がみられ,また皮膚症状では,丘疹.表皮剥離,苔癬化,落屑などの所見が改善される傾向が見られた。
キーワード アトピー性皮膚炎 エゴマ軟膏 掻痒感
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 76
終了ページ 81
ISSN 0918-7839
言語 日本語
論文のバージョン publisher
NAID 120002308418
JaLCDOI 10.18926/14965
タイトル(別表記) 膵癌における癌遺伝子および癌抑制遺伝子
フルテキストURL 069_082_087.pdf
著者 越智 浩二| 松村 直樹| 一村 光子| 水島 孝明| 原田 英雄| 蓮岡 英明| 横山 元浩| 鶴見 哲也| 光延 文裕| 谷崎 勝朗|
抄録 Recent advances in molecular biology have revealed that a number of oncogenes (K-ras, erbB-2, and Met) and tumor suppressor genes (p53, p16, APC, and DCC) contribute to the development of pancreatic cancer. This paper reviewed the present knowledge of oncogenes and tumor suppressor genes relevant to pancreatic cancer. Further studies on molecular alterations in pancreatic cancer may lead to a better understanding of tumor biology, offering a possibility of development of new diagnostic and therapeutic approaches in the future.
キーワード Pancreatic cancer oncogene tumor suppressor gene genetic mutation
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 82
終了ページ 87
ISSN 0918-7839
言語 英語
論文のバージョン publisher
NAID 120002308547
JaLCDOI 10.18926/14968
フルテキストURL 069_088_092.pdf
著者 土海 智穂| 寺崎 佳代| 岡本 和代| 山田 修子|
抄録 関節の変形と骨破壊を伴い,排泄動作に支障をきたしている慢性関節リウマチ患者に対し改良パンツの作成を試みた。残存機能に合わせはきなれたパンツを=夫することにより,排泄動作が自立でき満足感が得られた。
キーワード 慢性関節リウマチ 改良衣類 排泄自立 満足感
出版物タイトル 岡大三朝分院研究報告
発行日 1998-12
69巻
開始ページ 88
終了ページ 92
ISSN 0918-7839
言語 日本語
論文のバージョン publisher
NAID 120002308379
著者 岡山大学医学部附属病院三朝分院看護部|
発行日 1998-12
出版物タイトル 岡大三朝分院研究報告
69巻
資料タイプ その他
著者 松原 扶美恵| 井上 妙子| 光延 彰子| 御舩 尚志| 谷崎 勝朗|
発行日 1998-12
出版物タイトル 岡大三朝分院研究報告
69巻
資料タイプ データ・データベース
著者 岡山大学医学部附属病院三朝分院|
発行日 1998-12
出版物タイトル 岡大三朝分院研究報告
69巻
資料タイプ その他