| JaLCDOI | 10.18926/AMO/30726 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ogata, Masana| Kakuwa, Katsutoshi| Kondo, Yoshiro| |
| 抄録 | To develop a new method for evaluating the intensity of workers’ exposures to toluene alone or toluene in mixed solvents, regression equations were calculated between the concentrations of toluene to which workers were exposed and the concentrations of hippuric acid or toluene in workers’ urine samples taken at the end of their shifts. Thereafter, the discriminant exposure concentration of the solvents in air, which was the concentration considered to discriminate exposure from non-exposure within a fi xed level of error using fi ducial ranges of individual specimens (DEC-I) or using confi dence ranges of regression equation (DEC-R), was measured by a scale. The devised equations were applied to calculate DEC-I or DEC-R accurately using the formulas expressing a regression line and its fi ducial ranges or confi dence ranges. The equations can calculate not only more precise values of DEC-I or DEC-R than can be measured by a scale, but can also calculate values corresponding to any level of error. Moreover, DEC-I and DEC-R can be defi ned by the equations. The concentration capable of discriminating TLV (threshold limit value) exposure from non-TLV exposure was estimated using fi ducial ranges (DTL-I) and then using confi dence ranges of the regression equation (DTL-R). |
| キーワード | biological monitoring exposure to toluene discriminant exposure concentration biomarker urinary toluene |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 331 |
| 終了ページ | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189977 |
| Web of Science KeyUT | 000243019000005 |
| JaLCDOI | 10.18926/AMO/30725 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ohtani, Shoichiro| Watanabe, Naomi| Kawata, Masashi| Harada, Kimiko| Himei, Masahiro| Murakami, Kazuharu| |
| 抄録 | Clostridium perfringens infection is a very rare cause of massive intravascular hemolysis, but it should always be kept in mind, since only early treatment can rescue patients from an otherwise rapidly fatal outcome. We report a case of a 78-year-old diabetic male who was admitted complaining of general fatigue, dark red urine, and vomiting. His blood revealed massive hemolysis. Computer tomography demonstrated huge liver abscess in the right lobe of the liver. About 1 h after admission, he suddenly fell into a critical condition. He died 3 h after admission in spite of intensive care and resuscitation. Clostridium perfringens was detected from the blood taken before death and from liver abscess by biopsy after death. We concluded that this patient died of acute massive intravascular hemolysis in septicemia caused by Clostridium perfringens infection. |
| キーワード | Clostridium perfringens intravascular hemolysis liver abscess |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 357 |
| 終了ページ | 360 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189980 |
| Web of Science KeyUT | 000243019000008 |
| JaLCDOI | 10.18926/AMO/30724 |
|---|---|
| フルテキストURL | Fulltext.pdf erratum_61_2_121.pdf |
| 著者 | Fujita, Osamu| Asanuma, Masato| Yokoyama, Teruhiko| Miyazaki, Ikuko| Ogawa, Norio| Kumon, Hiromi| |
| 抄録 | We examined the involvement of the signal transducer and activator of transcription 3 (STAT3) in bladder outlet obstruction (BOO)-induced bladder smooth muscle hypertrophy using a rat in vivo and in vitro study. BOO induced increases in bladder weight and bladder smooth muscle thickness 1 week after the operation. By using antibody microarrays, 64 of 389 proteins blotted on the array met our selection criteria of an INR value between > or = 2.0 and < or = 0.5. This result revealed up-regulation of transcription factors, cell cycle regulatory proteins, apoptosis-associated proteins and so on. On the other hand, down-regulation (INR value < or = 0.5) of proteins was not found. In a profiling study, we found an increase in the expression of STAT3. A significant increase in nuclear phosphorylated STAT3 expression was confirmed in bladder smooth muscle tissue by immunohistochemistry and Western blot analysis. Cyclical stretch-relaxation (1 Hz) at 120% elongation significantly increased the expression of STAT3 and of alpha-smooth muscle actin in primary cultured bladder smooth muscle cells. Furthermore, the blockade of STAT3 expression by the transfection of STAT3 small interfering RNA (siRNA) significantly prevented the stretch-induced increase in alpha-smooth muscle actin expression. These results suggest that STAT3 has an important role in the induction of bladder smooth muscle hypertrophy. |
| キーワード | benign prostatic hyperplasia bladder outlet obstruction bladder smooth muscle signal transducer and activator of transcription 3 (STAT3) small interfering RNA (siRNA) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 299 |
| 終了ページ | 309 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189973 |
| Web of Science KeyUT | 000243019000001 |
| JaLCDOI | 10.18926/AMO/30723 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ashizawa, Tatsuto| Okada, Ryosuke| Suzuki, Yoshiaki| Takagi, Makoto| Yamazaki, Tatsuyuki| Sumi, Tetsuo| Aoki, Toshiaki| Aoki, Tatsuya| |
| 抄録 | We investigated the diagnostic significance of IL-6 for lymph node metastasis and/or hepatic metastasis from colorectal cancer in 65 patients and evaluated the contributions of 8 factors (IL-6, HGF, IL-1beta, TNF-alpha, TGF-beta1, ELAM-1, ICAM-1, VCAM-1) toward Dukes.s classification of 53 patients. We also examined IL-6 expression in tumor tissue. From the receiver operating characteristic (ROC) curve analysis, an optimal cutoff value of 5.8 pg/ml was determined to classify lymph node and/or hepatic metastasis, and that of 6.3 pg/ml was determined to classify hepatic metastasis. These values indicated sensitivities of 55.0% and 71.4%, and specifi cities of 100% and 88.6%, respectively. IL-6, HGF, and ELAM-1 were very useful for distinguishing among Dukes.s A/B group, C group, and D group. In all cases with high IL-6 values (more than 25.0 pg/ml), immunohistochemical staining was positive for IL-6 in the cytoplasm of cancer cells. IL-6 is strongly suspected to be involved in lymph node and/or hepatic metastasis by promoting it through HGF, and serum IL-6 value (pg/ml) would be useful diagnostically to estimate whether or not there is a high risk of lymph node and/or hepatic metastasis. |
| キーワード | IL-6 colorectal cancer lymph node metastasis hepatic metastasis diagnostic signifi cance |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 325 |
| 終了ページ | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189976 |
| Web of Science KeyUT | 000243019000004 |
| JaLCDOI | 10.18926/AMO/30722 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Gonzalez, Daniel| Miyamoto, Osamu| Touge, Tetsuo| Sumitani, Kazunori| Kuriyama, Shigeki| Itano, Toshifumi| |
| 抄録 | Rats with 6-hydroxydopamine (6-OHDA)-induced lesions of the substantia nigra are used as a model of Parkinson’s disease (PD), and these “lesioned” rats exhibit a rotational behavior when further injected with apomorphine (APO). We examined whether lesions in the prefrontal cortex (PFC) could modify the rotational behavior in PD model rats. Rats initially received unilateral lesions of the substantia nigra by 6-OHDA injection, and then their rotational behavior was measured. Two PFC lesions were achieved by intracerebral infusions of ibotenic acid, followed by measurement of APOinduced rotation. Rotation was reduced by approximately 30ｵ after PFC injury. The PFC may have functional infl uences on the basal ganglia and may be involved in the pathophysiology of the rotational behavior of PD model rats. |
| キーワード | Parkinson model rat rotational behavior ibotenic acid 6-hydroxydopamine prefrontal cortex |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 319 |
| 終了ページ | 324 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189975 |
| Web of Science KeyUT | 000243019000003 |
| JaLCDOI | 10.18926/AMO/30721 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Inoue, Atsushi| Asaumi, Koji| Endo, Hirosuke| Fujiwara, Kazuo| Mitani, Shigeru| Ozaki, Toshifumi| |
| 抄録 | The present retrospective study assessed radiographs to determine socket wear in total hip arthroplasty (THA) with 22-mm zirconia or COP (Cobalt-Chrome alloy rich in Cobalt and Phosphorous) heads, and in cemented stems at more than 10 years after operation. Sockets of ultra high molecular weight polyethylene were used in each of two THA groups (13 hips each) in a clinical trial in our hospital between 1989 and 1990. Three observers carried out masked assessments of the radiographs. Upon fi nal examination, there was no remarkable loosening in the zirconia or COP group, and no case had required revision surgery as of 2005. There was a statistically signifi cant diff erence between the 2 groups in average annual linear wear, at 0.093 mm/year and 0.046 mm/year in the zirconia and COP groups, respectively. Volume wear and average annual volume wear were also signifi cantly greater in the zirconia group despite its superior mechanical strength and toughness in vitro. Our present fi ndings do not confi rm early expectations of lower wear in long-term results of 22-mm zirconia femoral heads used in THA. |
| キーワード | total hip arthroplasty zirconia head COP head polyethylene wear |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 311 |
| 終了ページ | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189974 |
| Web of Science KeyUT | 000243019000002 |
| JaLCDOI | 10.18926/AMO/30720 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Katayama, Seiichi| Nozu, Nanami| Yokoyama, Masako| Hitsumoto, Yasuo| |
| 抄録 | Clostridium perfringens is an anaerobic spore-forming pathogen of humans and animals. C. perfringens type A strains, 13, CPN50, and NCTC8237, isolated from human gas gangrene, bound specifically to human fi bronectin (Fn). The trypsin-treatment of the bacterial cells significantly reduced the Fn-binding. A ligand blotting analysis of all three C. perfringens strains revealed that 5 protein bands of 34 kDa, 29 kDa, 26 kDa, 17 kDa, and 12 kDa specifically bound to biotinylated Fn. These results suggest that C. perfringens possesses certain Fn-binding proteins on the cell surface. |
| キーワード | human fi bronectin fi bronectin-binding protein Clostridium perfringens (C. perfringens) |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 351 |
| 終了ページ | 355 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189979 |
| Web of Science KeyUT | 000243019000007 |
| JaLCDOI | 10.18926/AMO/30719 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Shinji, Toshiyuki| Lwin, Aye Aye| Gokan, Katsunori| Obika, Mikako| Ryuko, Hiromasa| Khin, Myo| Okada, Shigeru| Koide, Norio| |
| 抄録 | Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identifi ed as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The fi ndings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classifi cation. |
| キーワード | HCV genotype type 6 subgroup Myanmar HCV core phylogenetic analysis |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2006-12 |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 345 |
| 終了ページ | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189978 |
| Web of Science KeyUT | 000243019000006 |