ID | 14045 |
Eprint ID | 14045
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フルテキストURL | |
タイトル(別表記) | The role of the KATP channel in functional and reactive myocardial hyperemia
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著者 |
小林 博夫
岡山大学医学部循環器内科学教室
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抄録 | To evaluate the role of the KATP channel in regulating coronary tonus in response to increases in myocardial oxygen conaumption, and reactive hypermia following ischemia, coronary blood flow was measured with glibenclamide, a KATP channel blocker (50μmol/l ic.) and pinacidil, a KATP channel opener, (10μmol/l ic.) The following interventions were applied in the control and during intracoronary infusions of glibenclamide alone or glibenclamide plus pinacidil : 1) intravenous infusion of isoproternol (0.125μg/kg/min), 2) aortic constriction to raise the mean aortic pressure by 30%. The slope of the regression line of coronary conductance of mycardial oxygen consumption was significantly decreased with glibenclamide (p<0.05), but returned to the baseline with pinacidil, both during isoproterenol infunsion and aortic constriction. Reactive hyperemia following a 20-sec coronary occlusion was also attennuated with glibenclamide and recovered with pinacidil. These findings suggest that the KATP channel regulates coronary artery tonus during the increase in myocardial oxygen consumption and transient myocardial ischemia.
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キーワード | KATP channel
glibenclamide
myocardial oxygen consumption
coronary conductance
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備考 | 原著
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発行日 | 1994
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 106巻
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号 | 5-6号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 451
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終了ページ | 460
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_451/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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