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ID 14045
Eprint ID
14045
FullText URL
106_451.pdf 549 KB
Title Alternative
The role of the KATP channel in functional and reactive myocardial hyperemia
Author
Kobayashi, Hiroo
Abstract
To evaluate the role of the KATP channel in regulating coronary tonus in response to increases in myocardial oxygen conaumption, and reactive hypermia following ischemia, coronary blood flow was measured with glibenclamide, a KATP channel blocker (50μmol/l ic.) and pinacidil, a KATP channel opener, (10μmol/l ic.) The following interventions were applied in the control and during intracoronary infusions of glibenclamide alone or glibenclamide plus pinacidil : 1) intravenous infusion of isoproternol (0.125μg/kg/min), 2) aortic constriction to raise the mean aortic pressure by 30%. The slope of the regression line of coronary conductance of mycardial oxygen consumption was significantly decreased with glibenclamide (p<0.05), but returned to the baseline with pinacidil, both during isoproterenol infunsion and aortic constriction. Reactive hyperemia following a 20-sec coronary occlusion was also attennuated with glibenclamide and recovered with pinacidil. These findings suggest that the KATP channel regulates coronary artery tonus during the increase in myocardial oxygen consumption and transient myocardial ischemia.
Keywords
KATP channel
glibenclamide
myocardial oxygen consumption
coronary conductance
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
451
End Page
460
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_451/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma