Knee replacement arthroplasty is indicated for the patient with advanced knee pain, knee deformation, and knee functional disorder. The aim of this study was to estimate loosening after a knee replacement arthroplasty. Loosening is measured by a frequency response function, and mobility by random vibration. The modal parameters for the knee joint are obtained by applying a modal analysis to the frequency response function. The values decrease as the knee joint prosthesis loosened. These parameters serve as an index for the condition between a thighbone and the prosthesis. The various indexes will greatly clarify the stage of advance in the loosening of knee-joint prostheses.