Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

A study on the galactosyltransferase activity of human gastric mucosa. Part 2. Gastric mucosal UDP galactosyltransferase activity of gastric ulcer patients and normal subjects.

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Published Date
1987-06-30
Abstract
Biopsied specimens of gastric mucosa of normal subjects and patients with gastric ulcer were obtained under routine gastrofiberscopy. UDP-galactosyltransferase activity was measured with the use of ovomucoid as a substrate. In endoscopically normal subjects, UDP-galactosyltransferase activity of the fundic gland area was significantly (p<0.01) higher than that of the pyloric gland area. In ulcer patients without anti-ulcer treatment, UDP-galactosyltransferase activity was elevated in the mucosa surrounding the ulcer at the healing stage and red scarring stage as compared with the corresponding area of non-ulcer individuals. However, under administration of an H(2)-blocker, the change in UDP-galactosyltransferase activity was not observed. These observations may suggest that (1) increased glycoprotein synthses may be a physiological response of the gastric mucosa to the ulcer and may promote ulcer healing, and that (2) the process of the H(2)-blocker induced ulcer healing may not be associated with the apparent increase in glycoprotein synthesis.
Keywords
gastric ulcer
mucosal glycoprtein
UDP-galactosyltransferase
gastric mucosal atrophy
H(2) blocker
ISSN
0030-1558
NCID
AN00032489