Journal of Okayama Medical Association
Published by Okayama Medical Association

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4-Amino-3(RS)-hydroxybutanoic acid maleateの抗けいれん作用に関する研究

Numoto, Akihiro
Thumnail 95_987.pdf 3.84 MB
Abstract
Effects of 4-amino-3(RS)-hydroxybutanoic acid maleate [(RS)-GABOB maleate] on threshold of pentylenetetrazol (PTZ) induced convulsion in the rabbit, and PTZ, bicuculline or penicillin induced seizure discharges in cats were examined and found following results; An intravenous (i.v.) injection of (RS)-GABOB maleate increased the threshold of convulsion, and an intracisternal (i.c.) injection of it prolonged latency for onset of spike discharges and decreased frequency and duration of the burst. The i.c. injection of (RS)-GABOB maleate apparently inhibited the both bicuculline and penicillin induced seizure discharges and the i.v. injection slightly depressed them. An injection of (RS)-GABOB maleate into the reticular formation absolutely inhibited the penicillin induced seizure discharges. The inhibitory action of (RS)-GABOB maleate on the penicillin induced abnormal discharges was stronger than that of (R)-GABOB.
Keywords
4-Amino-3(RS)-hydroxybutanoic acid maleate
ぺンチレンテトラゾール
ぺニシリン
ビククリン
ISSN
0030-1558
NCID
AN00032489