Studies on the function of diabetic leukocytes Part 1. Inpaired superoxide generation of diabetic granulocytes

Stimulation of human peripheral granulocytes by concanavalin A and cytochalasin D results in superoxide (O(2)) generation, which has an important role in the bactericidal activity of these cells. In this study, the O(2) generation of granulocytes obtained from eighteen normal subjects as controls and from forty-eight diabetics was assessed. In controls, O(2) generation was 6.03±1.31 (mean±SD) n mole per minute per 10(6) cells and in diabetics, 4.33±2.13 which was significantly lower than controls (p<0.001). According to fasting glucose level (FBS), diabetic subjects were classified into three subgroups; well (FBS≦140 mg per 100 ml), fair (140