Experiments were performed to examine the disturibution of Cornin on the organs in the rabbit. 1) Cornin was demonstrable in all segments of digestive tract. Relatively little Cornin was found in extracts of oesophagus and considerable amounts of Cornin in stomach. The intestine contained large amounts of Cornin. 2) All parts of the central nervous system contained Cornin. The large amounts were found in the hypothalamus and corpus quadrigeminus, whereas extracts of the telencephalon showed little. 3) In adition to the digestive tract, other smooth muscle organs such as uterus, urinary bladder contained Cornin, although only in minute amounts. Other organs contained little amounts of Cornin.