Journal of Okayama Medical Association
Published by Okayama Medical Association

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Influences of free amino-acid on glucose metabolism in the brain Part Ⅱ. On epileptogenic cerebral cortex

Yamamoto, Yasuhisa
71_313.pdf 1.31 MB
Published Date
1959-01-31
Abstract
The influences of the free amino-acids upon the glucose metabolism were investigated in the cerebral cortex removed from the epileptogenics and non-epileptogenics. Glucose metabolism decreased in the epileptogenic cerebral cortex, compared with the nonepileptogenic one. In the non-epileptogenic cerebral cortex, these free aminoacids accelerate the utilization of glucose, in the following order of γ-aminobutyric acid, aspartic acid, asparagine, glutamine, glutamic acid from the most to the least, while in the epileptogenic one in the order of aspartic acid, glutamic acid, asparagine, γ-aminobutyric acid and glutamine. These amino-acids have more pronounced function to accelerate the glucose metabolism in the epileptogenic brain than the nonepileptogenic.
ISSN
0030-1558
NCID
AN00032489