Influences of free amino-acids on glucose metabolism in the brain Part Ⅰ. on cerebral local anaphylaxis rabbits

There are many kinds of free amino-acids in the brain, most of which are glutamic acid, glutamine, asparatic acid. asparagine, γ-aminobutyric acid etc. The author has investigated the influences of these amino-acids upon the glucose metabolism in the brain of the normal and the cerebral local anaphylactic (C. L. A.) rabbits. Glutamic acid, glutamine and γ-aminobutyric acid accelerate the utilization of glucose in the brain of the normal as well as the C. L. A. rabbits, aspartic acid and asparagine accelerate that of glucose in the C. L. A. rabbits, while they have no influence on that in the normal. It is clarified that all of these amino-acids have the function to restore the decreased utilization of glucose in the C. L. A. rabbits to more than the normal level.