Experimental and clinical studies on the changes and their inhibition of the serum protein fractions as the by-effects by blood transfusion, Part Ⅲ. Experimental studies on the changes and their inhibition of the serum protein fractions by heterogenous blood transfusion

Human whole blood was injected to the normal rabbits at the rate of 8-12 cc per kg, thus the by-effects were caused. In the contrast, group, a severe shock resulted: some died directly after the transfusion and others died within several hours with anuria or oligtiria. In the groups with Ravonal or Anergen, however, these symptoms were inhibited, especially in the group with Ravonal. The hemolysis was similar in all of these groups, but it decreased in the groups with Anergen or with Ravonal with the lapse of time, especially in the latter. The γ-globulin increased temporarily in the contrast group and the gronp with Anergen, then decreased markedly with the lapse of time, thus the severe symptom or death resulted. In the groups with Ravonal, however, the γ-globulin slightly decreased temporarily and then rather increased after 3 hours.