Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

Hemodialysis membrane with a negative charge : Modeling glomerular basement membrane

Nagake, Yoshio
105_317.pdf 295 KB
Published Date
1993
Abstract
The glomerular basement membrane (GBM) regulates protein permeability by acting as both a size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG) which forms the charge barrier of the GBM contains a sulfonic acid base, we prepared negatively charged membranes by adding a sulfonic acid base to EVAL (ethylene vinyl alcohol) membranes. The permeabilities os the various proteins in these membranes were compared with those of conventional neutrally charged EVAL membranes. The permselectivity for proteins of negatively charged EVAL membranes depends largely upon the interrelation between the pore size of the membranes and size of the proteins. The negatively charged EVAL membranes had a higher selective permeability than the conventional neutrally charged EVAL membranes. Therefore, a negative charge within the dialyzer might produce higher selective permeability than conventional dialyzers.
Keywords
透析膜
腎糸球体基底膜
size barrier
charge barrier
スルホン酸基
ISSN
0030-1558
NCID
AN00032489