Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

腎糸球体基底膜をモデルとした理想的な透析膜作製に関する基礎的研究

長宅 芳男 岡山大学医学部第三内科学教室
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抄録
The glomerular basement membrane (GBM) regulates protein permeability by acting as both a size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG) which forms the charge barrier of the GBM contains a sulfonic acid base, we prepared negatively charged membranes by adding a sulfonic acid base to EVAL (ethylene vinyl alcohol) membranes. The permeabilities os the various proteins in these membranes were compared with those of conventional neutrally charged EVAL membranes. The permselectivity for proteins of negatively charged EVAL membranes depends largely upon the interrelation between the pore size of the membranes and size of the proteins. The negatively charged EVAL membranes had a higher selective permeability than the conventional neutrally charged EVAL membranes. Therefore, a negative charge within the dialyzer might produce higher selective permeability than conventional dialyzers.
キーワード
透析膜
腎糸球体基底膜
size barrier
charge barrier
スルホン酸基
ISSN
0030-1558
NCID
AN00032489