Journal of Okayama Medical Association
Published by Okayama Medical Association

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尿路感染症患者分離 Proteus mirabilis の病原性発現因子の解析

Murotani, Katsuhisa
Thumnail 103_963.pdf 4.17 MB
Abstract
Proteus mirabilis has several pathogenic factors such as adherent ability to urinary tract epitherial cells, urease, motility and resistance to urine. The pathogenic activities of clinically isolated P. mirabilis were analyzed. Higher pathogenic strains (No. 25 and No. 30) which had morphologically different pili but had a higher density of pili showed strong adherent activity to bladder epithelial cells of mouse and rat. These strains also showed a clear chemotaxis to urinary tract tissue extracts. These findings indicate that the combination of adherent, chemotaxis and urease activities is essential for causing of tipical kidney infection by P. mirabilis.
Keywords
P. mirabilis
尿路感染
病原因子
走化性
ウレアーゼ
付着性
Note
原著
ISSN
0030-1558
NCID
AN00032489