検索結果 47530 件
| JaLCDOI | 10.18926/AMO/47264 |
|---|---|
| フルテキストURL | 65_6_387.pdf |
| 著者 | Ohtsu, Tadahiro| Toda, Ryouhei| Shiraishi, Tomonobu| Toyoda, Hirokuni| Toyozawa, Hideyasu| Kamioka, Yasuaki| Ochiai, Hirotaka| Shimada, Naoki| Shirasawa, Takako| Hoshino, Hiromi| Kokaze, Akatsuki| |
| 抄録 | Empirical data indicative of the health conditions and medical needs of homeless persons are scarce in Japan. In this study, with the aim of contributing to the formulation of future healthcare strategies for the homeless, we conducted a self-administered questionnaire survey and interviews at a park in Shinjuku Ward, Tokyo, to clarify the living conditions of homeless persons and their health conditions and awareness about the availability of medical treatment. Responses from 55 homeless men were recorded (response rate:36.7%). With the exception of one person, none of them possessed a health insurance certificate. Half of the respondents reported having a current income source, although their modal monthly income was 30,000 yen($1 was approximately 90 yen). The number of individuals who responded "yes" to the questions regarding "Consulting a doctor on the basis of someone's recommendation" and "Being aware of the location of the nearest hospital or clinic" was significantly higher among those who had someone to consult when they were ill than among those who did not (the odds ratios [95% confidence intervals] were 15.00 [3.05-93.57] and 11.45 [1.42-510.68], respectively). This showed that whether or not a homeless person had a person to consult might influence his healthcare-seeking behavior. When queried about the entity they consulted (multiple responses acceptable), respondents mentioned "life support organizations" (61.1%) and "public offices" (33.3%). Overall, 94.5% of the respondents were aware of swine flu (novel influenza A (H1N1)). Their main sources of information were newspapers and magazines. On the basis of these findings, with regard to the aim of formulating healthcare strategies for homeless persons, while life support organizations and public offices play significant roles as conduits to medical institutions, print media should be considered useful for communicating messages to homeless persons. |
| キーワード | homeless persons person to consult seeking medical treatment healthcare swine flu |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 387 |
| 終了ページ | 393 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189479 |
| Web of Science KeyUT | 000298516900005 |
| JaLCDOI | 10.18926/AMO/47263 |
|---|---|
| フルテキストURL | 65_6_379.pdf |
| 著者 | Shiraki, Teruo| Saito, Daiji| |
| 抄録 | The aim of this study was to clarify the prevalence of coronary risk factors in order to characterize the prognostic factors in elderly patients and to also identify any factors beneficial for the prevention of further cardiac events and death. We studied 888 patients with ST-elevation acute myocardial infarction who were admitted within 48h of symptom onset. The patients were divided into 3 groups according to age for comparison of variables:a younger group (n＝99) aged＜50, a middle-aged group (n＝435)＞51 years but＜70 years and an elderly group (n＝354) aged＞71 years. The elderly group had higher rates of female gender, pulmonary congestion, in-hospital mortality, and atrial fibrillation and a higher plasma concentration of high-sensitivity CRP (hs-CRP) (p＜0.05). Hypertension, diabetes mellitus, and dyslipidemia were more common in the middle-aged group (p＜0.05). The prevalence of smokers and the plasma level of total cholesterol, LDL-cholesterol and triglycerides were lower in the elderly group (p＜0.05). The grade of collateral circulation was highest in the elderly group, but the success rate of reperfusion therapy was lowest. Multiple regression analysis showed that age, pulmonary congestion, CKD and hs-CRP were predictors of in-hospital mortality.This investigation indicated that elderly patients with acute myocardial infarction have different clinical characteristics than younger patients. A specific algorithm might be needed in elderly patients, and could use hs-CRP, eGFR and atrial fibrillation as factors. |
| キーワード | acute myocardial infarction coronary risk factor elderly |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 379 |
| 終了ページ | 385 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189478 |
| Web of Science KeyUT | 000298516900004 |
| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| フルテキストURL | 65_6_369.pdf |
| 著者 | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| キーワード | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| JaLCDOI | 10.18926/AMO/47261 |
|---|---|
| フルテキストURL | 65_6_363.pdf |
| 著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r＝－0.232, p＝0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men. |
| キーワード | abdominal circumference estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 363 |
| 終了ページ | 367 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189476 |
| Web of Science KeyUT | 000298516900002 |
| JaLCDOI | 10.18926/AMO/47260 |
|---|---|
| フルテキストURL | 65_6_353.pdf |
| 著者 | Ichihara, Eiki| Kiura, Katsuyuki| Tanimoto, Mitsune| |
| 抄録 | Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. However, angiogenesis includes a complex and multistep process that has not been sufficiently elucidated. In this review, we focus on signaling pathways related with tumor angiogenesis and several antiangiogenic agents approved by the United States Food and Drug Administration or under investigation. |
| キーワード | angiogenesis cancer |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 353 |
| 終了ページ | 362 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189475 |
| Web of Science KeyUT | 000298516900001 |
| 著者 | 押木 俊之| |
|---|---|
| 出版物タイトル | |
| 資料タイプ | その他 |
| 著者 | 岡山医学会| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | その他 |
| 著者 | 江原 猪知郎| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 藤原 晧| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 片木 龍藏| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 藤田 正夫| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 吉岡 好助| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 佐藤 倶正| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 尾藤 太| |
|---|---|
| 発行日 | 1927-02-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 445号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 阿部 大吾| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | ヴァラドワジ プラディープ リシクリスナ| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 月岡 清夏| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 宣 超| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 俵 志江| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 藤井 直| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |