検索結果 47501 件
| JaLCDOI | 10.18926/40149 |
|---|---|
| タイトル（別表記） | A subsequent report on the new McKinney type mass spectrometer in the Institute for Thermal Spring Research, Okayama University |
| フルテキストURL | pitsr_041_003_007.pdf |
| 著者 | 松葉谷 治| |
| 抄録 | Since the installation in April 1970, the McKinney type mass spectrometer has maintained a good condition and about 5000 isotopic analyses of oxygen, carbon and sulfer has been cerried out so far. The ion source filament was changed to spiral one from single wire. Consequently three times sensitivity and the longer life of filament were obtained. Gradual changes in the ratio of potential divider (β) and the sensitivity (|△ E(0)(2)|/E(0)(1)) for the difference of β have been observed (Table 1). Because these changes are opposite in trend but similar in degree, it is supposed that these changes are caused by decrease of feed-back resister value in the balancing system. Although there remain some problems in the corrections for the difference in observed isotopic tatio between two cases that a same CO(2) is fed to ion source from the ST side of inlet system on the one hand and from the X side on the another, the reproducibility of the measurement of isotopic ratio for long period is about ±O.1‰ (Table 2, Fig. 1). δ(18)O values of standard waters, MSA-1 and MSA-2, measured during a period from May to Dec. 1970 and in Sep. 1971 yielded good agreements implying the reproducibility of the measurement to be constant (Table 3). Both calculated δ(18)O values relative to a given sample based on each observed δ(18)O value relative to two different samples agreed each other. It is concluded that the linearity of observed a-value holds over a range of 30‰ (Table 4). |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1972-03-25 |
| 巻 | 41巻 |
| 開始ページ | 3 |
| 終了ページ | 7 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398147 |
| JaLCDOI | 10.18926/40148 |
|---|---|
| タイトル（別表記） | The effect of pH of water on the measurement of oxygen isotopic ratio by means of CO(2)-H(2)O isotopic exchange technique |
| フルテキストURL | pitsr_041_001_002.pdf |
| 著者 | 松葉谷 治| |
| 抄録 | The effect of pH of water on the measurement of oxygen isotopic ratio by means of CO(2)-H(2)O isotopic exchange technique was studied. In this study, a new type of reaction vessel was used (Fig. 1). The reaction time for equilibration using this new reaction vessel was nearly equal to that in the previous study (Fig. 2). The oxygen isotopic ratios of each two samples of pH 2, 4, 7, 8, 9, and 10 were measured. There is no significant difference between the observed δ(18)O values of these samples (Table 1). Therefore it is concluded that the effect of pH of water needs not to be taken into account on the measurement of oxygen isotopic ratio by means of CO(2)-H(2)O isotopic exchange technique. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1972-03-25 |
| 巻 | 41巻 |
| 開始ページ | 1 |
| 終了ページ | 2 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398148 |
| 著者 | 岡山大学温泉研究所| |
|---|---|
| 発行日 | 1972-03-25 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 41巻 |
| 資料タイプ | その他 |
| 著者 | 岡山大学温泉研究所| |
|---|---|
| 発行日 | 1972-03-25 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 41巻 |
| 資料タイプ | その他 |
| 著者 | 岡山大学温泉研究所| |
|---|---|
| 発行日 | 1973-03-25 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 42巻 |
| 資料タイプ | その他 |
| 著者 | 岡山大学温泉研究所| |
|---|---|
| 発行日 | 1973-03-25 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 42巻 |
| 資料タイプ | その他 |
| JaLCDOI | 10.18926/40143 |
|---|---|
| タイトル（別表記） | Rheumatoid arthritis and Sjögren's syndrome |
| フルテキストURL | 042_031_045.pdf |
| 著者 | 市川 幸延| |
| 抄録 | 1. Parotid Sialography Parotid sialograms were investigated in 29 patients with classical or definite RA according to the criteria of the American Rheumatism Association (one of whom had scleroderma), 5 patients with SLE (according to the Dubois's criteria, three were definite, one probable and another possible SLE), 3 patients with other autoimmune diseases (Hashimoto's thyroiditis, colitis ulcerosa and undiagnosed collagen disease), 3 patients with polyarthralgia and 10 patients with nonautoimmune diseases. Sialographic technique was performed by modified Rubin's Method using contrast medium Conray-400. Sialectasis which is pathognomonic of Sjögren's syndrome (SS) alone was observed in 6 patients with RA (20.7%) (3 punctate and 3 globular patterns) and 2 patients with SLE (one punctate and another globular pattern). Retention of the contrast medium in the duct for at least 5 minutes after the injection was observed in patients with RA, one patient with SLE and one patient with colitis ulcerosa. Sial ectasis and retention almost always existed together, and were observed in patients from young to older one. Although dilatation of the Stensen's duct and subalveolar dissection also existed together, they were observed in only older patients. It appeared that the former is the specific findings of SS and the latter is the non-specific findings according to the aging. Dry mouth was complained in 7 sialectasis (87.5%), 3 subalveolar dissection (60.0%), 10 retention (62.5%) and 9 normal sialogram (37.5%). Salivary hyposecretion (less than 10 ml/10min) was observed in 4 sialectasis (50%), one subalveolar dissection (20%), 6 dilatation of the Stensen's duct (37.5%), 5 retention (45.5%) and one normal sialogram (4.2%). These results show that sialectasis and retention are well correlated with salivary hyposecretion, but dry mouth is not so diagnostic in SS. Two patients with SLE had sialectasis were young women and showed normal salivary and lacrimal secretion. These cases may be supported by Heaton's hypothesis that SS is a benign and chronic form of SLE, or thay may be a subclinical state of SS. 2. Schirmer test Sixty seven patients (36RA, 6SLE, 3 other autoimmune diseases, 3 polyarthralgia and 19 non-autoimmune diseases) were examined by Schirmer test. Besides lacrimal hyposecretion was observed in RA and other autoimmune diseases, it began in younger age. These results show that autoimmune diseases have a sicca element in themselves. Compared with the results of sialography, Schirmer test was not correlated with sialectasis and retention. Dry eye was complained in only 4 patients (13.3%) with lacrimal hyposecretion (less than 10mm/5min) and all patients with dry eye had keratoconjunctivitis sicca (KCS). Dry eye is more diagnostic than Schirmer test. 3. Corneal staining by 1% rose bengal solution Twenty five patients with RA or SLE were examned corneal staining (Holm's type A) was observed in 5 patients with RA (20%). Staining of the medial and lateral bulbar conjunctiva (Holm's type B and C) were observed in 6 patients with RA (24%) and one patient with SLE. Nine patients with positive staining (type A, B and C) (75%) showed lacrimal hyposecretion. Dry eye was complained in 4 patients with type A staining (80%), but no patient with type B and C complained dry eye. Dry eye appears to be specific for the diagnosis of SS as sialectasis on the sialogram. 4. Salivary secretion All amount of saliva was collected during ten minutes chewing two pieces of gum. All of 21 patients with non-autoimmune diseases showed more than 10 ml/10min, and slight degree of salivary hyposecretion was observed with aging. Nine patients with RA (25.7%) showed salivary hyposecretion (less than 10ml/10min), besides it began in younger age. It was also observed in patients with other autoimmune diseases. Only 36.4% patients with salivary hyposecretion showed sialectasis on the sialogram. It can be supposed that patients with sialectasis and good salivary secretion are subclinical states of SS, and that this state is depends on the compensative function of the glands. Therefore, it is impossible to suppose the salivary dysfunction from the complaints of patients alone. It is required that saliva must be analysed not only quantitativly but also qualitativly (such as RA factor, complement and lysozome). Dry mouth was not only complained in 9 patients who showed salivary hyposecretion (81.8%). but in 10 patients showed normal secretion (50%). Dry mouth appears to be less specific for the diagnosis of SS than dry eye. 5. Diagnosis of SS Vanslow's criteria of SS was modified as follows. (1) Major : ① Sialectasis or salivary gland enlargement ② Positive corneal staining (type A) ③ Classical or definite RA (according to the criteria of the ARA) (2) Minor : ① Arthritis ② History ot salivary gland swelling ③ Dry mouth or salivary hyposecretion (less than 10ml/10min) ④ Dry eye or positive Schirmer test (less than 10mm/5min). Three major was diagnosed as definite, 2 major as probable and one major with one or more minor as possible SS. Of 35 patients with RA, definite (8.6%), probable (17.1%) and possible SS (54.3%) were obserevd. Two of SLE (33.3%) were possible SS. One patients with undiagnosed collagen disease was possible SS. Clinically, definite and probable SS may be diagnosed as Sjögren's syndrome. Two possible SS with SLE may be supporsed as subclinical states of SS who do not yet exhibite full criteria. Compared with the clinical and laboratory findings of these definite, probable and possible SS with RA, it was supporsed that positive antinuclear factor or positive LE cells in RA patients almost always represents SS, drug allergy, especially to gold therapy may be a manifestation of SS. Hypergammaglobulinemia, extreme elevation of erythrocyte sedimentation rate, struma, lymphnode enlargement in RA patients must be suspected of SS. Although one possible SS with SLE and one probable SS with RA showed positive ANF (peripheral pattern), it is impossible to differentiate SS from SLE by ANF alone. Because Suzuki et al. reported that 15.4% of SS had showed positive ANF (peripheral pattern). Examinations of salivary glands including sialography must be performed in patients with SLE in the future. To detect a subclinical SS, sialography and corneal staining must be performed even in patients with no sicca symptom, because of the compensatory functions of salivary and lacrimal glands. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 31 |
| 終了ページ | 45 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532309 |
| JaLCDOI | 10.18926/40142 |
|---|---|
| タイトル（別表記） | A case of systemic lupus erythematosus with idiopathic thrombocytopenic purpura |
| フルテキストURL | pitsr_042_025_029.pdf |
| 著者 | 市川 幸延| 池上 忠興| 北山 稔| 森永 寛| |
| 抄録 | A 24-year-old woman was presented in whom thrombocytopenic purpura appeared during antiinflammatory drugs therapy for arthralgia. At that time she had a positive LE cell preparation, positive antinuclear factor and false positive serum test for syphilis. Steroid hormon and ACTH therapy were started under the diagnosis of systemic lupus erythematosus. In the 23-rd hospital days, she had a negative LE cell preparation, negative antinuclear factor and negative serum test for syphilis. In the 28-th days after stopping steroid hormon and ACTH therapy, positive LE cell preparation and positive antinuclear factor appeared again. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 25 |
| 終了ページ | 29 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398146 |
| JaLCDOI | 10.18926/40141 |
|---|---|
| タイトル（別表記） | Preliminary experiments of electron probe X-ray microanalyzer (JXA5A) |
| フルテキストURL | pitsr_042_009_023.pdf |
| 著者 | 田崎 耕市| 平野 英雄| |
| 抄録 | Preliminary experiments on the accuracy of quantitative microprobe analysis for the instrument set in the Institute for Themal Spring Research, Okayama University were carried out. Dead time of the instrument ranged about 5.5-5.6 microsecond, which delayed 1.5 microsecond than usual value. Bombarding by finely focused electron beam, intensities of the characteristic X-ray of alkali metal such as NaKα and KKα decreased drastically in five to ten minutes. Intensities of the characteristic X-ray decreased in relation to the degree of off-focusing, when the spectrometer fixed at optically focused position. Readjusting of spectrometer after every move of sample was indispensable for the proof of accurate intensities. Applying BENCE and ALBEE'S correction method, empirical a factors was approved of preferable for quantitative analyses of silicates than calculated α factors. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 9 |
| 終了ページ | 23 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398145 |
| JaLCDOI | 10.18926/40140 |
|---|---|
| タイトル（別表記） | Zoned alternation of gibbsite and clay mInerals in the vermicular gibbsite |
| フルテキストURL | pitsr_042_001_007.pdf |
| 著者 | 田崎 和江| |
| 抄録 | Vermicular gibbsite aggregates found in the weathered pumice layer (the Kurayoshi pumice) at Yotsuzuka, western part of Tottori Prefecture, range in size from 5 to lOmm (Fig.1). They are more or less twisted and show some cleavages perpendicular to the long axis. Vermicular gibbsite are milky white colored and usually coated with dark brown color. X-ray diffraction patterns show strong renections for gibbsite, kaoline minerals, hydrobiotite and a relatively small amount of hydrated halloysite (Fig.3), Kaoline minerls are rather abundant at the white part. On the other hand, the dark brown part is rich in hydrobiotite. Differential thermal analysis shows the endothermic reaction for the dehydration of gibbsite at 310℃ and of kaoline minerals, hydrated halloysite and hydrobiotite at 550℃ (Fig.4). Electron microscopy shows that the gibbsite consist of peculiarly warped rods (Plate 1). The clay minerals which are looked like "cracked rice grain" are seemingly kaoline minerals or hydrated halloyslte. By the electron microprobe scanning across the vermicular gibbsite, the triform structure is revealed, such as the gibbsite rich part, the hydrobiotite rich part and kaoline minerals rich part (Fig.5 and 6). Gibbsite and clay minerals (hydrobiotite or kaoline minerals) grow alternately zone by zone (Fig.7). The width of each zone ranges in size from 20 to 40 micron. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398144 |
| 著者 | 岡山大学温泉研究所| |
|---|---|
| 発行日 | 1973-03-25 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 42巻 |
| 資料タイプ | その他 |
| 著者 | 岡山大学温泉研究所| |
|---|---|
| 発行日 | 1973-03-25 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 42巻 |
| 資料タイプ | その他 |
| JaLCDOI | 10.18926/40137 |
|---|---|
| タイトル（別表記） | Two cases of bile duct anomalies |
| フルテキストURL | 044_047_053.pdf |
| 著者 | 村上 直樹| 時岡 正明| 市川 幸延| 池上 忠興| 高杉 潔| 北山 稔| |
| 抄録 | We reported two cases of biIe duct anomalies detected by percutaneons transhepatic cholangiography. The first case was a 53-years-old woman who had a long cystic duct running paralleI to, and apparently adhered to a common hepatic duct distally, thus forming one large duct separated by a thin membrane within. Stenosis of the lower bile duct and subsequent dilatation of the proximal part of the duct were also demonstrated. In the second case, 5-years-old girl, the most conspicuous findings include stenosis of the extrahepatic duct with the resultant dilatation of the proximal par t of the common hepatic duct and bilateral hepatic ducts. Distally displaced opening of the common biIe duct to the duodenum and aberrant run of the duodenum were also disrcovered radiographically. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1975-03-25 |
| 巻 | 44巻 |
| 開始ページ | 47 |
| 終了ページ | 53 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/40136 |
|---|---|
| タイトル（別表記） | Oxygen Isotopic Composition of Water in the Living Things : Preliminary Analyses and Discussions |
| フルテキストURL | pitsr_044_061_075.pdf |
| 著者 | 木島 宣明| |
| 抄録 | Oxygen isotope analysis was carried out, by use of a new method (oxalate equilibration method) of preparing CO(2) for mass spectrometry, on water samples extracted from a number of biological samples collected in Misasa Town and Hashizu Coast, Tottori Prefecture. The δ values (the per mil enrichment of (18)O in sample waters relative to the Standard Mean Ocean Water) were suggested to be distributed in the living things as follows. The water absorbed by plant roots was supposed to have the same δ value with the water outside it (δs. about -8‰), and in a rapidly transpiring plant, this water reached the leaves, partly infiltrating into the phloem. When transpiration was slow, on the other hand, the isotopic composition of ascending xylem sap was modified by the exchange of water with phloem. where leaf water with a higher δ value was migrating. As Gonfiantini et aI. (1965) and Dongmann et al. (1972) have odserved, leaf waters were enriched markedly in (18)O in the daytime. A criterion of the δ of leaf water may be the sum of δs and △δ that corresponds to the (18)O fractionation factor in the H(2)O(I)-H(2)O(v) system. The sum comes to about 0‰ at ordinary leaf temperatures. and really δ values near 0‰ were observed in leaves of some herbaceous plants, in exudate from a tip of vine of Kudzu, in body fluid of herbivorous insects, etc., but higher δs (up to +19‰) were also observed in some other leaves such as pine needles, Especially leaves showed an increase in δ by about 10 ‰ toward the pnd of November when the average temperature fell below 10℃, probably because of accumulation of the daily enrichment as a resul t of slow water absorption and circulation. A few plant species grown on a dune were analyzed and it seemed that, among them, herbaceous plants were dependent on spraied sea water and pine trees on ground water. δ's of petal water were dispersed (-9～-3‰), probably according to the volume-to-transpirational flux ratio of water in the petals. Succurent fruits in enlarging stage seemed to have lower δ's near δs, but in maturing stagp δ's increaspd to about -4‰, i.e., to the avpraged δ of Ieaf water in the day and night. Herbivorous insects (imagines and la rvae) in general had distinctly higher δ values than carnivorous insects, the border being at -1‰. However, lower δ's at about -5‰ were obserbed on aphides which might have been sucking somewhat dilutpd leaf water from seave tube cells. Sometimes the δ of a herbivorous insect was a few per mil higher than that of the leaf it was nibbling, probably as a result of evaporation of water from the insect and of respiration. The level at about -3‰ common for carnivorous insects could not be explained, although tipula and chironomus making a swarm also showed a δ value on the level. Blood of a heron did not show such a low δ as supposed from its food habit. As compared with the drinking water of -8‰, blood and urine were found to have an identical δ in the range of -4 to -5‰ in either mouse or man, The δ value of the oxidation water produced in man's body was estimated to be about -6‰ from an approximate water balance. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1975-03-25 |
| 巻 | 44巻 |
| 開始ページ | 61 |
| 終了ページ | 75 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002383784 |
| JaLCDOI | 10.18926/AMO/40135 |
|---|---|
| フルテキストURL | 64_4_263.pdf |
| 著者 | Pavelić, Jasminka| Čulić, Srdjana| Čulić, Vida| |
| 抄録 | The occurrence of Langerhans cell histiocytosis (LCH) and another malignancy in the same patient is infrequent but has been recognized. The genetic changes that could be responsible for LCH and/or concomitant leukemia development are obscure. To the best of our knowledge, this is the first description of constitutional maternally derived inv (9) (p12;q13) in an LCH patient, and also of the development of common ALL Ph after LCH diagnosis and therapy. The potential significance of these findings [inv (9)LCHALL Ph] and their mutual relationship are unknown. Therefore, cooperative studies of large numbers of patients are needed to identify the common risk factors, if any. |
| キーワード | acute lymphoblastic leukemia genetic changes langerhans cell histiocytosis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 263 |
| 終了ページ | 265 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802544 |
| Web of Science KeyUT | 000281384400008 |
| JaLCDOI | 10.18926/AMO/40134 |
|---|---|
| フルテキストURL | 64_4_257.pdf |
| 著者 | Moritani, Norifumi| Yamada, Tomohiro| Mizobuchi, Koichi| Wakimoto, Mari| Ikeya, Yoko| Matsumura, Tatsushi| Mishima, Katsuaki| Iida, Seiji| |
| 抄録 | The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites. Here, we report a case of an ALT of the tongue, with a review of the literature. A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue. Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless. We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia. Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia. Three years after the operation, the tongue demonstrated good healing without paresthesia or dysfunction, and to date there has been no evidence of recurrence. |
| キーワード | atypical lipomatous tumor well-differentiated liposarcoma tongue |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 257 |
| 終了ページ | 261 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802543 |
| Web of Science KeyUT | 000281384400007 |
| JaLCDOI | 10.18926/AMO/40133 |
|---|---|
| フルテキストURL | 64_4_249.pdf |
| 著者 | Masumoto, Akio| Masuyama, Hisashi| Takamoto, Norio| Akahori, Yoichiro| Hiramatsu, Yuji| |
| 抄録 | It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties. The aim of this study was to investigate the relationship between pregnancy induced hypertension (PIH) and the placental expression of antiangiogenic PRL fragments and cathepsin D. Placental expression of PRL fragments and cathepsin D was evaluated by Western blot analysis in a group of 9 pregnant women consisting of 5 normal pregnancies and 4 severe PIH cases. Antiangiogenic PRL fragments were detected in 4 placental samples from all PIH cases but not detected in those from normal pregnancies (p0.05). The expression of cathepsin D in PIH placentas was significantly lower than that in those without PIH (p0.05), while the placental expression of procathepsin D was significantly greater in PIH cases than in the normal pregnancies (p0.05). These data suggest that antiangiogenic PRL fragments in the placenta may be present only in PIH cases, and that PRL fragments in the placenta might be implicated in the pathophysiology of PIH. |
| キーワード | pregnancy induced hypertension preeclampsia prolactin prolactin fragment cathepsin-D |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 255 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802542 |
| Web of Science KeyUT | 000281384400006 |
| JaLCDOI | 10.18926/AMO/40132 |
|---|---|
| フルテキストURL | 64_4_243.pdf |
| 著者 | Myo-Khin| Myat-Tin-Htwe-Kyaw| Yi-Yi-Kyaw| Ohmar-Lwin| Myat-Phone-Kyaw| Khin-May-Oo| Shimono, Kunio| Koide, Norio| Okada, Shigeru| |
| 抄録 | The efficacy of AntiOxidant Biofactor (AOB(R)) for the management of apparently healthy subjects with chronic hepatitis C infection was investigated. A total of 60 subjects (35 males, 25 females) participated in the trial. AOB was given orally in 2 packs (3g per pack) 3 times per day. 17 subjects had taken AOB for 3 years, 31 subjects up to 2 years, and 41 subjects up to one year. The initial mean (SD) serum alamine aminotransferase (ALT) level was 46.3+/-35.4IU/L, and significant (p0.05, paired t-test) reductions in the mean serum ALT levels were observed at 6 months (38.6+/-21.5IU/L), 18 months (31.9+/-18.1IU/L), 2 years (31.2+/-14.6IU/L), and 3 years (28.0+/-15.9IU/L). Those presenting with high serum ALT levels (30 subjects) demonstrated significant levels (p0.05, paired t-test) of reduction in the mean serum ALT levels at 6, 12, 18, 24, and 36 months of treatment. No side effects were observed and the AOB treatment was well tolerated by all subjects. |
| キーワード | hepatitis C AntiOxidant Biofactor (AOB®) ALT level |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 243 |
| 終了ページ | 248 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802541 |
| Web of Science KeyUT | 000281384400005 |
| JaLCDOI | 10.18926/AMO/40131 |
|---|---|
| フルテキストURL | 64_4_233.pdf |
| 著者 | Matsuoka, Hiroyuki| Ikezawa, Tsunetaka| Hirai, Makoto| |
| 抄録 | We are producing a transgenic mosquito, a flying syringe, to deliver a vaccine protein to human beings via the saliva the mosquito deposits in the skin while biting. The mosquito produces a vaccine protein in the salivary gland (SG) and deposits the protein into the host's skin when it takes the host's blood. We chose circumsporozoite protein (CSP), currently the most promising malaria vaccine candidate, to be expressed in the SG of Anopheles stephensi. To transform the mosquitoes, plasmid containing the CSP gene under the promoter of female SG-specific gene, as well as the green fluorescent protein (GFP) gene under the promoter of 3xP3 as a selection marker in the eyes, was injected into more than 400 eggs. As a result, five strains of GFP-expressing mosquitoes were established, and successful CSP expression in the SG was confirmed in one strain. The estimated amount of CSP in the SG of the strain was 40ng per mosquito. We allowed the CSP-expressing mosquitoes to feed on mice to induce the production of anti-CSP antibody. However, the mice did not develop anti-CSP antibody even after transgenic mosquitoes had bitten them several times. We consider that CSP in the SG was not secreted properly into the saliva. Further techniques and trials are required in order to realize vaccine-delivering mosquitoes. |
| キーワード | malaria salivary gland flying syringe transgenic mosquito vaccine |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 233 |
| 終了ページ | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802540 |
| Web of Science KeyUT | 000281384400004 |
| JaLCDOI | 10.18926/AMO/40130 |
|---|---|
| フルテキストURL | 64_4_225.pdf |
| 著者 | Ohtsu, Tadahiro| Kokaze, Akatsuki| Shimada, Naoki| Kaneita, Yoshitaka| Shirasawa, Takako| Ochiai, Hirotaka| Hoshino, Hiromi| Takaishi, Masahiro| |
| 抄録 | Over the past two decades, the liquor industry in Japan has strived to address alcohol-related problems through initiatives such as warnings in the various media. In this study, we conducted an Internet-based questionnaire survey to examine general consumer awareness of such warnings, and the media by which they are conveyed, on the consumption of alcoholic beverages. A total of 985 subjects (males:487, females:498) in age groups ranging from 20s to 70s responded (response rate:22.4%). The awareness rates for warnings regarding underage drinking, drunk driving, and drinking during pregnancy, and those for messages encouraging moderation in drinking, were 96.4%, 83.7%, 59.6%, and 45.5%, respectively. Logistic regression analysis adjusted for habitual alcohol consumption demonstrated significant gender- and/or age-based differences in the rates of awareness of warnings and the media publicizing them. For example, the odds ratio of awareness among women of warnings against underage drinking was significantly higher than that of awareness among men. Issues that must be addressed in the future include:(1) increasing public awareness about messages regarding drinking during pregnancy and drinking in moderation;(2) reviewing the wording of warnings to make them more effective;and (3) devising and employing, on a regular basis, more effective means of transmitting messages in consideration of gender and age. |
| キーワード | alcoholic beverages warnings consumer awareness Internet-based survey |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 225 |
| 終了ページ | 232 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802539 |
| Web of Science KeyUT | 000281384400003 |