検索結果 348 件
| JaLCDOI | 10.18926/AMO/68650 |
|---|---|
| フルテキストURL | 79_2_117.pdf |
| 著者 | Gautam, Abhishek| Kenawadekar, Rahul| Hattiholi, Virupaxi| Maste, Praful Suresh| |
| 抄録 | Neural tube defects are common congenital anomalies, typically presenting early due to visible swelling and/or neurological deficits. Rarely, cystic swellings are neglected until adulthood, with only 14 cases of malignancy developing in an untreated meningomyelocele reported to date. We describe the case details of a 26-year-old Indian woman with this rare complication. Magnetic resonance imaging revealed a low-lying spinal cord with spinal dysraphism, cord herniation, and a cystic lesion. The biopsy confirmed a well-differentiated squamous cell carcinoma. Malignant transformation in an untreated myelomeningocele is rare, with chronic irritation and infection as proposed causes. Early biopsy and treatment are crucial for its management. |
| キーワード | squamous cell carcinoma meningomyelocele occult spinal dysraphism |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-04 |
| 巻 | 79巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 117 |
| 終了ページ | 121 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/68648 |
|---|---|
| フルテキストURL | 79_2_101.pdf |
| 著者 | Isozaki, Hiroshi| Matsumoto, Sasau| Takama, Takehiro| Isozaki, Yuka| |
| 抄録 | To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes. |
| キーワード | breast cancer postoperative irradiation radiation therapy sentinel lymph nodes recurrence |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-04 |
| 巻 | 79巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 101 |
| 終了ページ | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/68645 |
|---|---|
| フルテキストURL | 79_2_075.pdf |
| 著者 | Higaki, Fumiyo| Morimitsu, Yusuke| Iguchi, Toshihiro| Hwang, Sung Il| Kitayama, Takahiro| Takahashi, Yuka| Uka, Mayu| Akagi, Noriaki| Sugaya, Akiko| Mitsuhashi, Toshiharu| Matsui, Yusuke| Hiraki, Takao| |
| 抄録 | Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%. |
| キーワード | computed tomography photon-counting detector computed tomography ear ossicle energy-integrating detector computed tomography |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-04 |
| 巻 | 79巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| フルテキストURL | mjou_067_053_065.pdf |
|---|---|
| 著者 | Harrington, Joshua| Jones, Lenny| |
| 抄録 | A polynomial f(x) ∈ Z[x] of degree N is called monogenic if f(x) is irreducible over Q and {1, θ, θ2, . . . , θN−1} is a basis for the ring of integers of Q(θ), where f(θ) = 0. Define F(x) := xm+Axm−1+B. In this article, we determine sets of conditions on m, A, and B, such that the power-compositional trinomial F(xpn) is monogenic for all integers n ≥ 0 and a given prime p. Furthermore, we prove the actual existence of infinite families of such trinomials F(x). |
| キーワード | irreducible monogenic power-compositional trinomial |
| 発行日 | 2025-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Department of Mathematics, Faculty of Science, Okayama University |
| 開始ページ | 53 |
| 終了ページ | 65 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright ©2025 by the Editorial Board of Mathematical Journal of Okayama University |
| JaLCDOI | 10.18926/AMO/68362 |
|---|---|
| フルテキストURL | 79_1_051.pdf |
| 著者 | Miura, Taro| Kawasaki, Yoichi| Hamano, Hirofumi| Zamami, Yoshito| Sendo, Toshiaki| |
| 抄録 | Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected in human serum. Here, we investigated the histamine-producing effects in HMC-1 cells and the inflammatory cytokine release effects in RAW264 cells for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; and 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All four promoted histamine production in HMC-1 cells; however, they did not significantly affect the release of inflammatory cytokines in RAW264 cells. These findings suggest that these four photoinitiators induce inflammatory cytokine-independent histamine production, potentially contributing to histamine-mediated chronic inflammation in vitro. |
| キーワード | photoinitiator ink injection histamine inflammation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 51 |
| 終了ページ | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012160 |
| Web of Science KeyUT | 001440463800007 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Izumi, Mahiro| Hagiya, Hideharu| Otsuka, Yuki| Soejima, Yoshiaki| Fukushima, Shinnosuke| Shibata, Mitsunobu| Hirota, Satoshi| Koyama, Toshihiro| Otsuka, Fumio| Gofuku, Akio| |
| キーワード | Infection prevention and control Medical-engineering collaboration |
| 発行日 | 2025-01 |
| 出版物タイトル | American Journal of Infection Control |
| 巻 | 53巻 |
| 号 | 1号 |
| 出版者 | Elsevier BV |
| 開始ページ | 65 |
| 終了ページ | 69 |
| ISSN | 0196-6553 |
| NCID | AA10617749 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39127185 |
| DOI | 10.1016/j.ajic.2024.08.003 |
| Web of Science KeyUT | 001402079000001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.ajic.2024.08.003 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Baba, Yuki| Kawano, Seiji| Takaki, Akinobu| Kono, Yoshiyasu| Horii, Joichiro| Takahashi, Sakuma| Kawai, Daisuke| Kobayashi, Sayo| Okada, Hiroyuki| |
| キーワード | capsule endoscopy NSAIDs oxidative stress small intestinal mucosal injury |
| 発行日 | 2024-12-13 |
| 出版物タイトル | Medicine |
| 巻 | 103巻 |
| 号 | 50号 |
| 出版者 | Lippincott, Williams & Wilkins |
| 開始ページ | e40849 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39686450 |
| DOI | 10.1097/MD.0000000000040849 |
| Web of Science KeyUT | 001379055600020 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000040849 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsunaga, Kazuyuki| Yoshida‐Tsuboi, Ayaka| Inohara, Ken| Yoshida, Yasuko| Nakahama, Kanako| Sasaki, Kazuki| Souda, Fumie| Terasawa, Yuka| Shimoe, Yutaka| Takeuchi‐Hatanaka, Kazu| Yamamoto, Tadashi| Omori, Kazuhiro| Kohriyama, Tatsuo| Takashiba, Shogo| |
| キーワード | acute stroke dental intervention medical and dental cooperation oral health assessment tool severity |
| 発行日 | 2024-12-09 |
| 出版物タイトル | Geriatrics & Gerontology International |
| 巻 | 25巻 |
| 号 | 1号 |
| 出版者 | Wiley |
| 開始ページ | 48 |
| 終了ページ | 53 |
| ISSN | 1444-1586 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39654397 |
| DOI | 10.1111/ggi.15035 |
| Web of Science KeyUT | 001375306000001 |
| 関連URL | isVersionOf https://doi.org/10.1111/ggi.15035 |
| JaLCDOI | 10.18926/AMO/67869 |
|---|---|
| フルテキストURL | 78_6_439.pdf |
| 著者 | Yamashita, Mampei| Tanaka, Takayuki| Sumida, Yorihisa| Yamazaki, Shoto| Hara, Yuki| Fukuda, Akiko| Hisanaga, Makoto| Wakata, Koki| Araki, Masato| Eguchi, Susumu| |
| 抄録 | Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.6%) were diagnosed with GC (GC group) based on our retrospective pathologic diagnosis. We comparatively evaluated the patient backgrounds and surgical outcomes between the GC group and non-GC group. The GC group was significantly older and included more hypertensive patients than the non-GC group. The GC group was prescribed more antibiotics as initial treatment than the non-GC group, and they had more days between onset and surgery. The preoperative white blood cell count and C-reactive protein values were significantly higher in the GC group than in the non-GC group, and these values were predictive factors for GC. Cholecystectomy required a longer operation time and caused greater blood loss in the GC group. The GC group also had longer hospitalization times than the non-GC group; however, no significant differences were observed in terms of postoperative complications. In conclusion, gangrenous changes should be assessed when diagnosing cholecystitis, and appropriate treatment, such as surgery or drainage, should be undertaken. |
| キーワード | gangrenous cholecystitis acute cholecystitis laparoscopic cholecystectomy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-12 |
| 巻 | 78巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 447 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39719316 |
| Web of Science KeyUT | 001397799300002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fuji, Tomokazu| Umeda, Yuzo| Takagi, Kosei| Hioki, Masayoshi| Yoshida, Ryuichi| Endo, Yoshikatsu| Yasui, Kazuya| Nobuoka, Daisuke| Mitsuhashi, Toshiharu| Fujiwara, Toshiyoshi| |
| キーワード | Education High-volume hospital Learning curve Pancreaticoduodenectomy |
| 備考 | The version of record of this article, first published in BMC Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12893-024-02677-9| |
| 発行日 | 2024-11-20 |
| 出版物タイトル | BMC Surgery |
| 巻 | 24巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 366 |
| ISSN | 1471-2482 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024. |
| 論文のバージョン | publisher |
| PubMed ID | 39563307 |
| DOI | 10.1186/s12893-024-02677-9 |
| Web of Science KeyUT | 001360181700004 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12893-024-02677-9 |
| JaLCDOI | 10.18926/AMO/67667 |
|---|---|
| フルテキストURL | 78_5_423.pdf |
| 著者 | Sakamoto, Shinya| Tabuchi, Motoyasu| Yoshimatsu, Rika| Hishida, Ai| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| 抄録 | Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia, is usually observed in children and infants, although more recently adult-onset nesidioblastosis has also been described. We present a case of nesidioblastosis in a 78-year-old man that was detected by 111In-pentetreotide single photon emission computed tomography (SPECT/CT). The patient was transferred to our hospital’s emergency department in a hypoglycemic coma. Dynamic enhanced CT could detect no lesion in the pancreas, but an 111In-pentetreotide SPECT/CT scan performed after a similar episode four weeks later showed increased focal uptake at the head of the pancreas. The results of a selective arterial calcium injection test were negative. After careful consideration and discussion among colleagues, surgical intervention was selected, and a pancreaticoduodenectomy was performed. On histology, there were elevated numbers of Langerhans islets in the pancreatic head, and the islets themselves appeared enlarged. Hypertrophic β-cells comprised the majority, but α-cells, δ-cells and pancreatic polypeptide were also detected in the islets. Based on the histopathological results and repeated hyperinsulinemic hypoglycemic crises, the patient was finally diagnosed with adult-onset nesidioblastosis. He had no hypoglycemic symptoms during outpatient follow-up examination. Since 111In-pentetreotide SPECT/CT may be able to detect nesidioblastosis, clinicians should consider this relatively new-modality examination when encountering such cases. |
| キーワード | 111In-pentetreotide nesidioblastosis single-photon emission computed tomography hyperinsulinemic hypoglycemia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-10 |
| 巻 | 78巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 423 |
| 終了ページ | 428 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39467661 |
| Web of Science KeyUT | 001343346400009 |
| レファレンス | Kaczirek K and Niederle B: Nesidioblastosis: an old term and a new understanding. World J Surg (2004) 28: 1227-1230.| Gottsponer JA, Baker DL, Osborn T, Estrada MM, Giorgakis E, Burdine LJ and Patel RB: Non-insulinoma pancreatogenous hypoglycemia syndrome due to nesidioblastosis following bariatric Roux-en-Y gastric bypass. J Surg Case Rep (2023) 2023: rjad050.| García-Santos EP, Manzanares-Campillo Mdel C, Padilla-Valverde D, Villarejo-Campos P, Gil-Rendo A, Muñoz-Atienza V, Sánchez-García S, Puig-Rullán AM, Rodríguez-Peralto JL and Martín-Fernández J: Nesidioblastosis. a case of hyperplasia of the islets of Langerhans in the adult. Pancreatology (2013) 13: 544-548.| Sempoux C, Guiot Y, Jaubert F and Rahier J: Focal and diffuse forms of congenital hyperinsulinism: the keys for differential diagnosis. Endocr Pathol (2004) 15: 241-246.| Doi S, Yamada T, Kito Y, Obara S, Fujii Y, Nishimura T, Kato T, Nakayama H, Tsutsumi M and Okamura R: Adult-onset focal nesidioblastosis with nodular formation mimicking insulinoma. J Endocr Soc (2021) 6: bvab185.| Service GJ, Thompson GB, Service FJ, Andrews JC, Collazo-Clavell ML and Lloyd RV: Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med (2005) 353: 249-254.| Cao J, Kim C, Huynh T, Frugoli A, Henson H, Valdez V and Westhoff-Pankratz T: BYPASS-OMA: Hypoglycemic hyperinsulinemic nesidioblastosis after gastric bypass surgery-a case report and review of the literature. Case Rep Endocrinol (2022) 2022: 5472304.| Maeda Y, Yokoyama K, Takeda K, Takada J, Hamada H, Hujioka Y and Kudo SE: Adult-onset diffuse nesidioblastosis causing hypoglycemia. Clin J Gastroenterol (2013) 6: 50-54.| Thompson SM, Vella A, Thompson GB, Rumilla KM, Service FJ, Grant CS and Andrews JC: Selective arterial calcium stimulation with hepatic venous sampling differentiates insulinoma from nesidioblastosis. J Clin Endocrinol Metab (2015) 100: 4189-4197.| Doppman JL, Chang R, Fraker DL, Norton JA, Alexander HR, Miller DL, Collier E, Skarulis MC and Gorden P: Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium. Ann Intern Med (1995) 123: 269-273.| Zhao K, Patel N, Kulkarni K, Gross JS and Taslakian B: Essentials of insulinoma localization with selective arterial calcium stimulation and hepatic venous sampling. J Clin Med (2020) 9: 3091.| Kenney B, Tormey CA, Qin L, Sosa JA, Jain D and Neto A: Adult nesidioblastosis. Clinicopathologic correlation between pre-operative selective arterial calcium stimulation studies and post-operative pathologic findings. JOP (2008) 9: 504-511.| Johnbeck CB, Knigge U and Kjær A: PET tracers for somatostatin receptor imaging of neuroendocrine tumors: current status and review of the literature. Future Oncol (2014) 10: 2259-2277.| Francesconi AB, Matos M, Lee JC, Wyld DK, Clouston AD and Macfarlane D: Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. Ann Nucl Med (2009) 23: 497-499.| Arao T, Okada Y, Hirose A and Tanaka Y: A rare case of adult-onset nesidioblastosis treated successfully with diazoxide. Endocr J (2006) 53: 95-100.| Kato R, Nishimura A, Matsumura K, Kikuno S, Nagasawa K and Mori Y: Successful treatment of adult-onset nesidioblastosis by continuous subcutaneous octreotide infusion in a patient on hemodialysis. Clin Case Rep (2020) 9: 278-281.| |
| JaLCDOI | 10.18926/AMO/67662 |
|---|---|
| フルテキストURL | 78_5_377.pdf |
| 著者 | Hirano, Yuichi| Nouso, Kazuhiro| Kariyama, Kazuya| Hiraoka, Atsushi| Shiota, Shohei| Wakuta, Akiko| Yasuda, Satoshi| Toyoda, Hidenori| Tsuji, Kunihiko| Hatanaka, Takeshi| Kakizaki, Satoru| Naganuma, Atsushi| Tada, Toshifumi| Itobayashi, Ei| Ishikawa, Toru| Shimada, Noritomo| Takaguchi, Koichi| Tsutsui, Akemi| Nagano, Takuya| Imai, Michitaka| Nakamura, Shinichiro| Kumada, Takashi| Real-Life Practice Experts for HCC (RELPEC) Study Group in Japan| |
| 抄録 | We previously found that “albumin grade”, formerly called the “ALBS grade,” demonstrated significant capability for prognostic stratification in hepatocellular carcinoma (HCC) patients treated with lenvatinib. The purpose of the present study was to compare the performance of the albumin grade with that of the modified albumin-bilirubin (mALBI) grade in predicting overall survival of HCC patients with different BCLC stages and treatment types. We enrolled 7,645 Japanese patients newly diagnosed with HCC using the Akaike information criteria (AIC), likelihood ratio, and C-index in different Barcelona Clinic Liver Cancer (BCLC) stages and treatments. The albumin grade showed similar and slightly better performance than the mALBI grade for BCLC stage 0 and A and especially for patients who underwent curative surgery and ablation. In patients treated with transcatheter arterial chemoembolization, molecular targeted agents, and the best supportive care, the mALBI grade had better performance than the albumin grade. However, the differences of the indices were very small in all scenarios. Overall, the albumin grade was comparable in efficacy to the mALBI grade, showing particular benefit for patients with early-stage HCC. |
| キーワード | albumin grade hepatocellular carcinoma modified albumin-bilirubin grade |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-10 |
| 巻 | 78巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 377 |
| 終了ページ | 386 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39467656 |
| Web of Science KeyUT | 001343346400004 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hirata, Shoichiro| Hamada, Kenta| Iwamuro, Masaya| Mouri, Hirokazu| Miyahara, Koji| Tsuzuki, Takao| Yamauchi, Kenji| Kobayashi, Sayo| Takahashi, Sakuma| Takenaka, Ryuta| Hori, Shinichiro| Inoue, Masafumi| Toyokawa, Tatsuya| Nishimura, Mamoru| Ishiyama, Shuhei| Miyaike, Jiro| Kato, Ryo| Matsubara, Minoru| Yunoki, Naoko| Kanzaki, Hiromitsu| Kawahara, Yoshiro| Okada, Hiroyuki| Ishikawa, Hideki| Otsuka, Motoyuki| Okayama Gut Study Group| |
| キーワード | direct oral anticoagulants endoscopic submucosal dissection gastric cancer postprocedural bleeding warfarin |
| 発行日 | 2024-10-03 |
| 出版物タイトル | Journal of Gastroenterology and Hepatology |
| 巻 | 39巻 |
| 号 | 12号 |
| 出版者 | Wiley |
| 開始ページ | 2760 |
| 終了ページ | 2766 |
| ISSN | 0815-9319 |
| NCID | AA10727383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39363400 |
| DOI | 10.1111/jgh.16757 |
| Web of Science KeyUT | 001328472100001 |
| 関連URL | isVersionOf https://doi.org/10.1111/jgh.16757 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yokoyama, Sho| Honda, Hiroyuki| Otsuka, Yuki| Tokumasu, Kazuki| Nakano, Yasuhiro| Sakurada, Yasue| Matsuda, Yui| Sunada, Naruhiko| Hasegawa, Toru| Takase, Ryosuke| Omura, Daisuke| Soejima, Yoshiaki| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| キーワード | blood glucose diabetes mellitus long COVID omicron variant post-COVID-19 condition |
| 発行日 | 2024-07-13 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 13巻 |
| 号 | 14号 |
| 出版者 | MDPI |
| 開始ページ | 4099 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39064139 |
| DOI | 10.3390/jcm13144099 |
| Web of Science KeyUT | 001278836700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm13144099 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishii, Nobuhiro| Sakata, Yasushi| Murohara, Toyoaki| Ando, Kenji| Ikeda, Takanori| Mitsuhashi, Takeshi| Nogami, Akihiko| Shimizu, Wataru| Schwartz, Torri| Kayser, Torsten| Beaudoint, Caroline| Aonuma, Kazutaka| for HINODE Investigators| |
| キーワード | HeartLogic heart failure remote monitoring ICD CRT hospitalization |
| 発行日 | 2024-07-02 |
| 出版物タイトル | ESC Heart Failure |
| 巻 | 11巻 |
| 号 | 5号 |
| 出版者 | Wiley |
| 開始ページ | 3322 |
| 終了ページ | 3331 |
| ISSN | 2055-5822 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 38956896 |
| DOI | 10.1002/ehf2.14890 |
| Web of Science KeyUT | 001261066000001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ehf2.14890 |
| JaLCDOI | 10.18926/AMO/67201 |
|---|---|
| フルテキストURL | 78_3_259.pdf |
| 著者 | Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan| |
| 抄録 | The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients. |
| キーワード | multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902214 |
| Web of Science KeyUT | 001267351000007 |
| JaLCDOI | 10.18926/AMO/67198 |
|---|---|
| フルテキストURL | 78_3_237.pdf |
| 著者 | Muraoka, Osamu| Imai, Norio| Kuraishi, Tatsuya| Imai, Makoto| Fukuhara, Takashi| Yoshimine, Toshifumi| |
| 抄録 | Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period. |
| キーワード | fracture liaison services complications after admission secondary hip fracture mortality |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 237 |
| 終了ページ | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902211 |
| Web of Science KeyUT | 001267351000004 |
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| フルテキストURL | 78_3_227.pdf |
| 著者 | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| 抄録 | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| キーワード | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| JaLCDOI | 10.18926/AMO/66928 |
|---|---|
| フルテキストURL | 78_2_193.pdf |
| 著者 | Kashima, Hajime| Teraishi, Fuminori| Matsumi, Yuki| Shimamura, Hiroshi| Fujiwara, Toshiyoshi| |
| 抄録 | Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst. |
| キーワード | tailgut cyst laparoscopic resection fistula formation |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 193 |
| 終了ページ | 196 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688837 |
| Web of Science KeyUT | 001227932200003 |
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| フルテキストURL | 78_2_123.pdf |
| 著者 | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| 抄録 | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| キーワード | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |