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フルテキストURL BriMicroRes_Jou_3_2_190.pdf
著者 Mukherjee, Avik Kumar| Karmakar, Sumallya| Raj, Dibyendu| Ganguly, Sandipan|
キーワード Giardia genotyping mixed assemblages local isolates
発行日 2013-03-22
出版物タイトル British Microbiology Research Journal
3巻
2号
出版者 SCIENCEDOMAIN international
開始ページ 190
終了ページ 197
ISSN 22310886
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
DOI 10.9734/BMRJ/2013/2812
関連URL isVersionOf https://doi.org/10.9734/BMRJ/2013/2812
フルテキストURL Vaccine_32_A20-8.pdf
著者 Mullick, Satarupa| Mandal, Paulami| Mukti Kant Nayak| Ghosh, Souvik| De, Papiya| Rajendran, K.| Bhattacharya, Mihir K.| Mitra, Utpala| Ramamurthy, Thandavarayan| Kobayashi, Nobumichi| Chawla-Sarkar, Mamta|
キーワード Diarrhea Rotavirus India Kolkata G9 strains G2 strains
発行日 2014-08-11
出版物タイトル Vaccine
32巻
supplment 1号
出版者 Elsevier Science
開始ページ A20
終了ページ A28
ISSN 0264410X
NCID AA10491877
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 25091674
DOI 10.1016/j.vaccine.2014.03.018
Web of Science KeyUT 000340977500007
関連URL isVersionOf https://doi.org/10.1016/j.vaccine.2014.03.018
フルテキストURL Front_Microbiol_7_1250.pdf
著者 Ghosh, Raikamal| Sharma, Naresh C.| Halder, Kalpataru| Bhadra, Rupak K.| Chowdhury, Goutam| Pazhani, Gururaja P.| Shinoda, Sumio| Mukhopadhyay, Asish K.| Nair, G. Balakrish| Ramamurthy, Thadavarayan|
キーワード V.cholerae O139 ribotypes CT genotype CTX prophage PFGE
発行日 2016-08-09
出版物タイトル frontiers in Microbiology
7巻
出版者 Frontiers Media S.A.
開始ページ 1250
ISSN 1664302X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 27555841
DOI 10.3389/fmicb.2016.01250
Web of Science KeyUT 000381079700001
関連URL isVersionOf https://doi.org/10.3389/fmicb.2016.01250
フルテキストURL Plos_Negl_Trop_Dis_5386.pdf
著者 Imamura, Daisuke| Morita, Masatomo| Sekizuka, Tsuyoshi| Mizuno, Tamaki| Takemura, Taichiro| Yamashiro, Tetsu| Chowdhury, Goutam| Pazhani, Gururaja P.| Mukhopadhyay, Asish K.| Ramamurthy, Thandavarayan| Miyoshi, Shin-ichi| Kuroda, Makoto| Shinoda, Sumio| Ohnishi, Makoto|
備考 This research is supported by the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from Ministry of Education, Culture, Sport, Science & Technology in Japan, and Japan Agency for Medical Research and Development (AMED).|
発行日 2017-02-13
出版物タイトル PLOS Neglected Tropical Diseases
11巻
2号
出版者 PLOS
開始ページ e0005386
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 28192431
DOI 10.1371/journal.pntd.0005386
Web of Science KeyUT 000396406600020
関連URL isVersionOf https://doi.org/10.1371/journal.pntd.0005386
JaLCDOI 10.18926/AMO/56452
フルテキストURL 73_1_1.pdf
著者 Morizane, Shin|
抄録 Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD.
キーワード atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-02
73巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 6
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 30820048
JaLCDOI 10.18926/AMO/56178
フルテキストURL 72_4_401.pdf
著者 Wada, Nozomu| Ikeda, Fusao| Mori, Chizuru| Takaguchi, Koichi| Fujioka, Shin-ichi| Kobashi, Haruhiko| Morimoto, Yoichi| Kariyama, Kazuya| Sakaguchi, Kosaku| Hashimoto, Noriaki| Moriya, Akio| Kawaguchi, Mitsuhiko| Miyatake, Hirokazu| Hagihara, Hiroaki| Kubota, Junichi| Takayama, Hiroki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Takaki, Akinobu| Iwasaki, Yoshiaki| Okada, Hiroyuki|
抄録 Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR rates than 1B-mono infection (p=0.02). Female sex and RAVs were significant factors associated with treatment failure of this combination therapy for patients with HCV serogroup 1 infection. Mixed HCV infection other than 1B-mono infection would be useful for predicting treatment failure.
キーワード mixed genotype daclatasvir asunaprevir HCV serogrouping 1 infection
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2018-08
72巻
4号
出版者 Okayama University Medical School
開始ページ 401
終了ページ 406
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 30140089
JaLCDOI 10.18926/AMO/56073
フルテキストURL 72_3_275.pdf
著者 Morizane, Shin| Ouchida, Mamoru| Sunagawa, Ko| Sugimoto, Saeko| Kobashi, Mina| Sugihara, Satoru| Nomura, Hayato| Tsuji, Kazuhide| Sato, Atsushi| Miura, Yoshihiro| Hattori, Hiroaki| Tada, Kotaro| Huh, Wook-Kang| Seno, Akemi| Iwatsuki, Keiji|
抄録 Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients.
キーワード atopic dermatitis SPINK5 LEKTI serine protease inhibitor epidermal barrier dysfunction
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2018-06
72巻
3号
出版者 Okayama University Medical School
開始ページ 275
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29926005
フルテキストURL K0005289_other1.pdf
著者 Takeda, Midori| Ikeda, Masanori| Ariumi, Yasuo| Wakita, Takaji| Kato, Nobuyuki|
備考 学位審査副論文|
発行日 2012-07
出版物タイトル Journal of General Virology
93巻
7号
出版者 Cambridge Univ. Press for the Society for General Microbiology
開始ページ 1422
終了ページ 1431
ISSN 0022-1317
NCID AA00698722
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 22456614
DOI 10.1099/vir.0.040725-0
Web of Science KeyUT 000306348900003
関連URL https://doi.org/10.1099/vir.0.040725-0 http://ousar.lib.okayama-u.ac.jp/54272
フルテキストURL K0005288_other.pdf
著者 Sejima, Hiroe| Mori, Kyoko| Ariumi, Yasuo| Ikeda, Masanori| Kato, Nobuyuki|
キーワード HCV HCV RNA replication system Li23 cells Long-term RNA replication Upregulated host genes Downregulated host genes
備考 学位審査副論文|
発行日 2012-07
出版物タイトル Virus Research
167巻
1号
出版者 Elsevier Science
開始ページ 74
終了ページ 85
ISSN 0168-1702
NCID AA10642076
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 22579597
DOI 10.1016/j.virusres.2012.04.008
Web of Science KeyUT 000305496700010
関連URL https://doi.org/10.1016/j.virusres.2012.04.008 http://ousar.lib.okayama-u.ac.jp/54271
フルテキストURL PlantCellRep_36_4_611.pdf PlantCellRep_36_4_611_supl.pdf Supplemental_tables.xlsx
著者 Hisano, Hiroshi| Meints, Brigid| Moscou, Matthew J.| Cistue, Luis| Echávarri, Begoña| Sato, Kazuhiro| Hayes, Patrick M.|
キーワード Agrobacterium tumefaciens Doubled haploid Hordeum vulgare (barley) Single nucleotide polymorphism Transformation
発行日 2017-04
出版物タイトル Plant Cell Reports
36巻
4号
出版者 Springer
開始ページ 611
終了ページ 620
ISSN 0721-7714
NCID AA10635864
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28204911
DOI 10.1007/s00299-017-2107-2
Web of Science KeyUT 000398735600009
関連URL isVersionOf https://doi.org/10.1007/s00299-017-2107-2
著者 Yasuda, Yukiko| Sakai, Akiko| Ito, Sachio| Sasai, Kaori| Yamamoto, Hiromasa| Matsubara, Nagahide| Ouchida, Mamoru| Katayama, Hiroshi| Shimizu, Kenji|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54826
JaLCDOI 10.18926/AMO/54189
フルテキストURL 70_2_103.pdf
著者 Mu Mu Shwe| Hlaing Myat Thu| Khin Saw Aye| Aye Aye Myint| Mya Thida| Khin Shwe Mar| Khin Khin Oo| Khin Sandar Aye| Shigeru Okada| Kyaw Zin Thant|
抄録 Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identified oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in Myanmar. In total, 100 biopsy tissues of histologically confirmed anogenital cancers collected in 2008-2012 were studied, including 30 penile and 9 anal cancers from Yangon General Hospital and 61 vulvar cancers from Central Women's Hospital, Yangon. HPV-DNA testing and genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism. Overall, 34% of anogenital cancers were HPV-positive. HPV was found in 44.4% of anal (4/9), 36.1% of vulvar (22/61), and 26.7% of penile (8/30) cancers. The most frequent genotypes in anal cancers were HPV 16 (75%) and 18 (25%). In vulvar cancers, HPV 33 was most common (40.9%), followed by 16 (31.8%), 31 (22.7%), and 18 (4.6%). In penile cancers, HPV 16 (62.5%) was most common, followed by 33 (25%) and 18 (12.5%). This is the first report of evidencebased oncogenic HPV genotypes in anogenital cancers among men and women in Myanmar. This research provides valuable information for understanding the burden of HPV-associated cancers of the anus, penis, and vulva and considering the effectiveness of prophylactic HPV vaccination.
キーワード human papillomavirus (HPV) ano-genital cancer Myanmar genotyping of HPV cross-sectional study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 103
終了ページ 110
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094835
Web of Science KeyUT 000377626300005
著者 坂田 理香|
発行日 2015-12-31
出版物タイトル
資料タイプ 学位論文
著者 Ueda, Youki| Takeda, Midori| Mori, Kyoko| Dansako, Hiromichi| Wakita, Takaji| Kim, Hye-Sook| Sato, Akira| Wataya, Yusuke| Ikeda, Masanori| Kato, Nobuyuki|
発行日 2013-08-30
出版物タイトル PLOS ONE
8巻
8号
資料タイプ 学術雑誌論文
フルテキストURL K0005201_abstract_review.pdf K0005201_fulltext.pdf
著者 難波 真太郎|
発行日 2015-06-30
資料タイプ 学位論文
学位授与番号 甲第5201号
学位授与年月日 2015-06-30
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
JaLCDOI 10.18926/AMO/53560
フルテキストURL 69_4_237.pdf
著者 Nanba, Shintarou| Ikeda, Fusao| Fujioka, Shin-ichi| Araki, Yasuyuki| Takaguchi, Kouichi| Hashimoto, Noriaki| Seki, Hiroyuki| Takaki, Akinobu| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
抄録 The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51オ), and 89オ of them obtained sustained virological response (SVR), while 69オ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence<80オ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2.
キーワード hepatitis C virus interferon genotype 2 response-guided therapy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-08
69巻
4号
出版者 Okayama University Medical School
開始ページ 237
終了ページ 244
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26289915
Web of Science KeyUT 000365519100007
フルテキストURL K0005110 abstract_review.pdf K0005110_fulltext.pdf
著者 上田 優輝|
発行日 2015-03-25
資料タイプ 学位論文
学位授与番号 甲第5110号
学位授与年月日 2015-03-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著者 Mizuki, Yutaka| Takaki, Manabu| Okahisa, Yuko| Sakamoto, Shinji| Kodama, Masafumi| Ujike, Hiroshi| Uchitomi, Yosuke|
発行日 2014-11
出版物タイトル Human Psychopharmacology: Clinical and Experimental
29巻
6号
資料タイプ 学術雑誌論文
フルテキストURL K0005070_abstract_review.pdf K0005070_fulltext.pdf
著者 津崎 龍一郎|
発行日 2014-12-31
資料タイプ 学位論文
学位授与番号 甲第5070号
学位授与年月日 2014-12-31
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 日本語 英語
JaLCDOI 10.18926/AMO/53122
フルテキストURL 69_1_51.pdf
著者 Mu Mu Shwe| Kyi Kyi Nyunt| Okada, Shigeru| Harano, Teruo| Hlaing Myat Thu| Hla Myat Mo Mo| Mo Mo Win| Khin Khin Oo| KhinThet Wai| Khin Saw Aye| Myo Khin|
抄録 Persistent infection with oncogenic types of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. This study detected the oncogenic HPV genotypes in cervical neoplasia in relation to clinicopathological findings using a cross-sectional descriptive method in 2011 and 2012. Cervical swabs and colposcopy-directed cervical biopsy tissues were collected from 108 women (median age 45 years;range 20-78) showing cervical cytological changes at Sanpya General Hospital, Yangon, Myanmar. HPV DNA testing and genotyping were performed by polymerase chain reaction and restriction fragment length polymorphism. HPV was identified in women with cervical intraepithelial neoplasia (CIN) 1 (44.4%), CIN2 (63.2%), CIN3 (70.6%), and squamous cell carcinoma (SCC) (74.1%). The association between cervical neoplasia and HPV positivity was highly significant (p=0.008). Most patients infected with HPV were between 40-49 years of age, and the youngest were in the 20- to 29-year-old age group. The most common genotype was HPV 16 (65.6%) with the following distribution:70% in CIN1, 41.7% in CIN2, 91.7% in CIN3, and 60% in SCC. HPV-31 was the second-most frequent (21.9%):30% in CIN1, 33.3% in CIN2, 8.3% in CIN3, and 15% in SCC. The third-most frequent-genotype was HPV-18 (7.8%):8.3% in CIN1, and 20% in SCC. Another genotype was HPV-58 (4.7%):16.7% in CIN1 and 5% in SCC. The majority of CIN/SCC cases were associated with HPV genotypes 16, 31, 18, and 58. If oncogenic HPV genotypes are positive, the possibility of cervical neoplasia can be predicted. Knowledge of the HPV genotypes distribution can predict the effectiveness of the currently used HPV vaccine.
キーワード human papillomavirus genotyping Myanmar
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-02
69巻
1号
出版者 Okayama University Medical School
開始ページ 51
終了ページ 58
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25703171
Web of Science KeyUT 000349740300006