検索結果 272 件
| JaLCDOI | 10.18926/AMO/64032 |
|---|---|
| フルテキストURL | 76_5_519.pdf |
| 著者 | Ishioka, Yoko| Yamashita, Hiroyuki| Hamaguchi, Kinya| Kuwahara, Yoshitaka| Nakamura, Kaoru| Nakatsuka, Mikiya| |
| 抄録 | To examine the outcome of gestational blood pressure and birth weight in women with normal pre-pregnancy BMI (18.5-25 kg/m2) who are at the lower and upper limits of this range, i.e., slightly underweight or slightly overweight. Overall, 2,038 Japanese women with low -risk who had delivered during January 2014–December 2016 were classified according to their pre-pregnancy BMI: underweight (< 18.5 kg/m2), slightly underweight (18.5≤BMI<21 kg/m2), normal (21≤BMI<23 kg/m2), slightly overweight (23≤BMI<25 kg/m2) and overweight (≤ 25 kg/m2). Their blood pressure during each trimester and birth weight was evaluated. The slightly overweight group showed a significantly higher blood pressure than the underweight and slightly underweight groups. Birth weight was lower in the slightly underweight than in the slightly overweight group (p<0.01). The incidence rate of “heavy for dates” (HFD) infants was significantly higher in the slightly overweight and overweight groups than in the other groups (p<0.05 and p<0.01, respectively). Weight gain of < 7 kg significantly increased the rate of “light for dates” (LFD) infants, while a weight gain of ≥13 kg significantly increased the rate of HFD infants (p<0.05 and p<0.01, respectively). Blood pressure during pregnancy was ssociated with pre-pregnancy BMI. The birth weight of infants of low-risk pregnant women is affected by both pre-pregnancy BMI and gestational weight gain. |
| キーワード | birth weight blood pressure normal body weight pregnancy pre-pregnancy BMI |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 519 |
| 終了ページ | 526 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352798 |
| Web of Science KeyUT | 000884907100004 |
| フルテキストURL | fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf |
|---|---|
| 著者 | Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi| |
| キーワード | Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.| |
| 発行日 | 2022-09-25 |
| 出版物タイトル | Annals of Surgical Oncology |
| 巻 | 30巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1110 |
| 終了ページ | 1118 |
| ISSN | 1068-9265 |
| NCID | AA11016573 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Society of Surgical Oncology 2022 |
| 論文のバージョン | author |
| PubMed ID | 36161371 |
| DOI | 10.1245/s10434-022-12572-3 |
| Web of Science KeyUT | 000858651900003 |
| 関連URL | isVersionOf https://doi.org/10.1245/s10434-022-12572-3 |
| フルテキストURL | fulltext20221017-3.pdf figure20221017-3.pdf |
|---|---|
| 著者 | Morizane, Shin| Sunagawa, Ko| Nomura, Hayato| Ouchida, Mamoru| |
| キーワード | Atopic dermatitis Serine protease Kallikrein-related peptidases Lympho-epithelial Kazal-type-related inhibitor Protease -activated receptor 2 |
| 備考 | © 2022 Japanese Society for Investigative Dermatology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jdermsci.2022.06.004] . | This fulltext is available in July 2023.| |
| 発行日 | 2022-07 |
| 出版物タイトル | Journal of Dermatological Science |
| 巻 | 107巻 |
| 号 | 1号 |
| 出版者 | Elsevier BV |
| 開始ページ | 2 |
| 終了ページ | 7 |
| ISSN | 0923-1811 |
| NCID | AA1075636X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japanese Society for Investigative Dermatology |
| 論文のバージョン | author |
| PubMed ID | 35817663 |
| DOI | 10.1016/j.jdermsci.2022.06.004 |
| Web of Science KeyUT | 000863858700001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jdermsci.2022.06.004 |
| JaLCDOI | 10.18926/AMO/63906 |
|---|---|
| フルテキストURL | 76_4_465.pdf |
| 著者 | Bekku, Kensuke| Tsugawa, Takuji| Tsuboi, Kazuma| Noda, Gaku| Inoue, Yousuke| Murao, Wataru| Ebara, Shin| |
| 抄録 | We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk. |
| キーワード | metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 465 |
| 終了ページ | 472 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123162 |
| フルテキストURL | fulltext20220819-4.pdf figure20220819-4.pdf |
|---|---|
| 著者 | Tanabe, Yoshinori| Eto, Hidetoshi| |
| 備考 | © 2021 American Association of Medical Dosimetrists. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.meddos.2021.12.002] .| |
| 発行日 | 2022-01-03 |
| 出版物タイトル | Medical Dosimetry |
| 巻 | 47巻 |
| 号 | 2号 |
| 出版者 | Elsevier BV |
| 開始ページ | E13 |
| 終了ページ | E18 |
| ISSN | 0958-3947 |
| NCID | AA11536846 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 American Association of Medical Dosimetrists. |
| 論文のバージョン | author |
| PubMed ID | 34991966 |
| DOI | 10.1016/j.meddos.2021.12.002 |
| Web of Science KeyUT | 000832705200001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.meddos.2021.12.002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hashimoto, Masashi| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Tanaka, Takehiro| Maeda, Naoaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi| |
| キーワード | Esophagectomy Verrucous carcinoma Esophageal squamous cell carcinoma |
| 発行日 | 2022-07-04 |
| 出版物タイトル | Surgical Case Reports |
| 巻 | 8巻 |
| 号 | 1号 |
| 出版者 | Springer |
| 開始ページ | 128 |
| ISSN | 2198-7793 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35781764 |
| DOI | 10.1186/s40792-022-01486-7 |
| Web of Science KeyUT | 000820644000001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40792-022-01486-7 |
| JaLCDOI | 10.18926/AMO/63744 |
|---|---|
| フルテキストURL | 76_3_333.pdf |
| 著者 | Akagawa, Manabu| Miyakoshi, Naohisa| Tsuchie, Hiroyuki| Kasukawa, Yuji| Kawaragi, Takashi| Nagahata, Itsuki| Suzuki, Masazumi| Yoshikawa, Takayuki| Abe, Toshiki| Shimada, Yoichi| |
| 抄録 | We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture. |
| キーワード | atypical femoral fracture bowing deformity intramedullary nail teriparatide cephalomedullary screw |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790365 |
| Web of Science KeyUT | 000823568300013 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Minakuchi, Hajime| Fujisawa, Masanori| Abe, Yuka| Iida, Takashi| Oki, Kyosuke| Okura, Kazuo| Tanabe, Norimasa| Nishiyama, Akira| |
| キーワード | Sleep bruxism Management Systematic review Oral appliances Biofeedback therapy Cognitive-behavioral therapy Pharmacological therapy |
| 発行日 | 2022-11 |
| 出版物タイトル | Japanese Dental Science Review |
| 巻 | 58巻 |
| 出版者 | Elsevier Ltd. |
| 開始ページ | 124 |
| 終了ページ | 136 |
| ISSN | 1882-7616 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. |
| 論文のバージョン | publisher |
| PubMed ID | 35356038 |
| DOI | 10.1016/j.jdsr.2022.02.004 |
| Web of Science KeyUT | 000806374300002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jdsr.2022.02.004 |
| フルテキストURL | K0006542_abstract_review.pdf K0006542_fulltext.pdf K0006542_summary.pdf |
|---|---|
| 著者 | 吉永 香澄| |
| 発行日 | 2022-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6542号 |
| 学位授与年月日 | 2022-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2020 The Japanese Urological Association |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fukushima, Kazuhiko| Uchida, Haruhito A.| Fuchimoto, Yasuko| Mifune, Tomoyo| Watanabe, Mayu| Tsuji, Kenji| Tanabe, Katsuyuki| Kinomura, Masaru| Kitamura, Shinji| Miyamoto, Yosuke| Wada, Sae| Koyanagi, Taisaku| Sugiyama, Hitoshi| Kishimoto, Takumi| Wada, Jun| |
| キーワード | lupus nephritis lupus pneumonitis silicosis SLE |
| 発行日 | 2022-02-18 |
| 出版物タイトル | Medicine |
| 巻 | 101巻 |
| 号 | 7号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | e28872 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 35363197 |
| DOI | 10.1097/MD.0000000000028872 |
| Web of Science KeyUT | 000776738500059 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000028872 |
| フルテキストURL | fulltext20220413-7.pdf |
|---|---|
| 著者 | Mifune, Tomoyo| Tanabe, Katsuyuki| Nakashima, Yuri| Tanimura, Satoshi| Sugiyama, Hitoshi| Sato, Yasufumi| Wada, Jun| |
| キーワード | Vasohibin-1 Microtubules Detyrosination Podocytes |
| 備考 | © 2022 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbrc.2022.02.047] . | |
| 発行日 | 2022-4 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 599巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 93 |
| 終了ページ | 99 |
| ISSN | 0006-291X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Elsevier Inc. |
| 論文のバージョン | author |
| PubMed ID | 35180473 |
| DOI | 10.1016/j.bbrc.2022.02.047 |
| Web of Science KeyUT | 000759467800001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.bbrc.2022.02.047 |
| フルテキストURL | fulltext20220413-5.pdf |
|---|---|
| 著者 | Tanabe, Ryo| Hongo, Takashi| Mandai, Yasuhiro| Inaba, Mototaka| Yorifuji, Takashi| Nakao, Atsunori| Elmer, Jonathan| Naito, Hiromichi| |
| キーワード | DNAR EMT OHCA Stress |
| 発行日 | 2022-03-03 |
| 出版物タイトル | Resuscitation |
| 巻 | 173巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 61 |
| 終了ページ | 68 |
| ISSN | 0300-9572 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s) |
| 論文のバージョン | publisher |
| PubMed ID | 35143903 |
| DOI | 10.1016/j.resuscitation.2022.01.028 |
| Web of Science KeyUT | 000767483800011 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.resuscitation.2022.01.028 |
| JaLCDOI | 10.18926/CTED/63309 |
|---|---|
| タイトル（別表記） | Treatment of learning about marriage in High School Home Economics; Description Analysis of the Course of Study and Textbooks |
| フルテキストURL | cted_012_211.pdf |
| 著者 | 田邉 詩歩| 李 璟媛| |
| 抄録 | 本研究では，「多様化する結婚」という日本の現状を踏まえ，結婚に関連する学習内容が，高等学校家庭科においてどのように扱われているかを分析することを目的とし，平成11，21，30 年版の『高等学校学習指導要領』と平成21 年版に基づいて構成された「家庭基礎」の教科書10 冊を用いて結婚に関連する学習内容を分析した。分析の結果，教科書には，『学習指導要領』に基づいて結婚等に関連する法制度の記述がみられ，結婚をめぐる現状や変化を反映した学習内容が取り扱われていることを確認した。一方，法律婚，事実婚，同性婚など結婚に関連する語句については，教科書によって内容の記載の有無に差がみられ，多様化している現状の理解に十分対応しているとはいえないことも明らかになった。 |
| キーワード | 結婚(Marriage) 高等学校家庭科(High School Home Economics) 学習指導要領(Course of Study) 教科書(Textbooks) |
| 出版物タイトル | 岡山大学教師教育開発センター紀要 |
| 発行日 | 2022-03-30 |
| 巻 | 12巻 |
| 開始ページ | 211 |
| 終了ページ | 225 |
| ISSN | 2186-1323 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2022 岡山大学教師教育開発センター |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanabe, Katsuyuki| Matsuoka-Uchiyama, Natsumi| Mifune, Tomoyo| Kawakita, Chieko| Sugiyama, Hitoshi| Wada, Jun| |
| キーワード | corticosteroid drug-induced interstitial nephritis eosinophils mycophenolate mofetil polypharmacy |
| 発行日 | 2021-12-17 |
| 出版物タイトル | Medicine |
| 巻 | 100巻 |
| 号 | 50号 |
| 出版者 | Lippincott Williams ＆ Wilkins |
| 開始ページ | e28252 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 34918693 |
| DOI | 10.1097/MD.0000000000028252 |
| Web of Science KeyUT | 000731129100044 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000028252 |
| JaLCDOI | 10.18926/AMO/62818 |
|---|---|
| フルテキストURL | 75_6_755.pdf |
| 著者 | Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Nagai, Yasuo| Noma, Kazuhiro| Tanabe, Shunsuke| Maeda, Naoaki| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| 抄録 | Approximately 4% of patients with esophageal cancer develop a second primary malignancy in the upper gastrointestinal trunk. However, hepatectomy following esophagectomy for esophageal cancer has rarely been reported. We report the case of a 70-year-old man who underwent an esophagectomy for esophageal cancer with retrosternal gastric tube reconstruction. Nine years later, he developed hepatocellular carcinoma with tumor thrombus involving the left portal vein, and was successfully treated with left hemihepatectomy. Special attention should be paid to avoiding incidental injury of the gastric tube as well as the right gastroepiploic artery during the hepatectomy. |
| キーワード | liver resection, esophagectomy, retrosternal gastric tube reconstruction |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 755 |
| 終了ページ | 758 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955546 |
| Web of Science KeyUT | 000735319800004 |
| NAID | 120007180274 |
| JaLCDOI | 10.18926/AMO/62770 |
|---|---|
| フルテキストURL | 75_5_575.pdf |
| 著者 | Suzuki, Hayato| Imai, Norio| Hirano, Yuki| Endo, Naoto| |
| 抄録 | HipCOMPASS, a mechanical intraoperative support device used in total hip arthroplasty (THA), improves the cup-alignment accuracy. However, the alignment accuracy achieved by HipCOMPASS has not been specifically examined in obese patients. In this study, we retrospectively evaluated the relation between alignment accuracy and several obesity-related parameters in 448 consecutive patients who underwent primary THA using HipCOMPASS. We used computed tomography (CT) to measure the preoperative soft-tissue thickness of the anterior-superior iliac spine (ASIS) and pubic symphysis and the differences between preoperative and postoperative cup angle based on the cup-alignment error. We found significant correlations between the absolute value of radiographic anteversion difference and body mass index (r = 0.205), ASIS thickness (r = 0.419), and pubic symphysis thickness (r = 0.434). The absolute value of radiographic inclination difference was significantly correlated with ASIS (r = 0.257) and pubic symphysis thickness (r = 0.202). The receiver operating characteristic curve showed a pubic symphysis thickness of 37.2 mm for a ≥ 5° implantation error in both radiographic inclination and anteversion simultaneously. The cup-alignment error for HipCOMPASS was large in patients whose pubic symphysis thickness was ≥ 37.2 mm on preoperative CT. Our results indicate that methods other than HipCOMPASS, including computed tomography-based navigation systems, might be preferable in obese patients. |
| キーワード | HipCOMPASS total hip arthroplasty cup-alignment accuracy body mass index soft-tissue thickness |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 575 |
| 終了ページ | 583 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703040 |
| Web of Science KeyUT | 000711561600004 |
| NAID | 120007166670 |
| JaLCDOI | 10.18926/AMO/62767 |
|---|---|
| フルテキストURL | 75_5_549.pdf |
| 著者 | Isooka, Nami| Miyazaki, Ikuko| Asanuma, Masato| |
| 抄録 | Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. |
| キーワード | Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 549 |
| 終了ページ | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703037 |
| Web of Science KeyUT | 000711561600001 |
| NAID | 120007166678 |
| フルテキストURL | fulltext20211018-7a.pdf |
|---|---|
| 著者 | Watari, Shogo| Araki, Motoo| Matsumoto, Jun| Yoshinaga, Kasumi| Sekito, Takanori| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Kubota, Risa| Nishimura, Shingo| Wada, Koichiro| Kobayashi, Yasuyuki| Takeuchi, Hidemi| Tanabe, Katsuyuki| Kitagawa, Masashi| Morinaga, Hiroshi| Kitamura, Shinji| Sugiyama, Hitoshi| Ariyoshi, Noritaka| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| キーワード | Cytochrome P450 tacrolimus renal transplantation CYP2C19 vonoprazan rabeprazole |
| 備考 | © 2021 The Japanese Society for the Study of Xenobiotics. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.dmpk.2021.100407] .| |
| 発行日 | 2021-10-31 |
| 出版物タイトル | Drug Metabolism and Pharmacokinetics |
| 巻 | 40巻 |
| 出版者 | Elsevier Ltd. |
| 開始ページ | 100407 |
| ISSN | 13474367 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved. |
| 論文のバージョン | author |
| PubMed ID | 34352707 |
| DOI | 10.1016/j.dmpk.2021.100407 |
| Web of Science KeyUT | 000702719100002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.dmpk.2021.100407 |
| JaLCDOI | 10.18926/AMO/62379 |
|---|---|
| フルテキストURL | 75_4_415.pdf |
| 著者 | Sun, Jingkai| Lin, Wenfeng| Wang, Qixu| Sakai, Akiko| Xue, Ruizhi| Watanabe, Masami| Liu, Chunxiao| Sadahira, Takuya| Nasu, Yasutomo| Xu, Abai| Huang, Peng| |
| 抄録 | Human RAD17, as an agonist of checkpoint signaling, plays an essential role in mediating DNA damage. This hospital-based case-control study aimed to explore the association between RAD17 rs1045051, a missense sin-gle nucleotide polymorphism (SNP), and prostate cancer risk. Subjects were 358 prostate cancer patients and 314 cancer-free urology patients undergoing treatment at the Zhujiang Hospital of Southern Medical University in China. RAD17 gene polymorphism rs1045051 was evaluated by the SNaPshot method. Compared with the RAD17 gene polymorphism rs1045051 AA genotype, there was a higher risk of prostate cancer for the CC gen-otype (adjusted odds ratio [AOR] = 1.731, 95% confidence interval [95%CI] = 1.031−2.908, p = 0.038). Compared with the A allele, the C allele was significantly associated with the disease status (AOR = 1.302, 95%CI = 1.037−1.634, p = 0.023). All these findings indicate that in the SNP rs1045051, both the CC genotype and C allele may have a substantial influence on the prostate cancer risk. |
| キーワード | prostate cancer single-nucleotide polymorphisms cell cycle checkpoint rs1045051 RAD17 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 415 |
| 終了ページ | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511607 |
| Web of Science KeyUT | 000697944600002 |
| NAID | 120007146060 |
| JaLCDOI | 10.18926/AMO/62378 |
|---|---|
| フルテキストURL | 75_4_403.pdf |
| 著者 | Matoba, Ryo| Morizane, Yuki| |
| 抄録 | Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patient’s subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis. |
| キーワード | epiretinal membrane vitrectomy optical coherence tomography internal limiting membrane lamellar macular hole |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 403 |
| 終了ページ | 413 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511606 |
| Web of Science KeyUT | 000697944600001 |
| NAID | 120007146059 |