検索結果 47752 件
| タイトル（別表記） | Spatial Analysis and Ecological Approach to Local Society in Ancient Japan |
|---|---|
| フルテキストURL | 786_63_74_2015.pdf |
| 著者 | 今津 勝紀| |
| 備考 | 本研究は、「空間解析を通じた日本古代地域社会の研究」（基盤研究（C）研究代表者 岡山大学・社会文化科学研究科・教授･今津勝紀 課題番号15K02833）の成果である。| |
| 発行日 | 2015-10 |
| 出版物タイトル | 歴史評論 |
| 号 | 786号 |
| 出版者 | 歴史科学協議会 |
| 開始ページ | 63 |
| 終了ページ | 74 |
| ISSN | 0386-8907 |
| NCID | AN00255224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| NAID | 40020584694 |
| オフィシャル URL | http://www.maroon.dti.ne.jp/rekikakyo/magazine/contents/kakonomokuji/786.html| |
| フルテキストURL | esr_024_1_contents.pdf |
|---|---|
| 著者 | Department of Earth Sciences, Faculty of Science, Okayama University | |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2017-12-27 |
| 巻 | 24巻 |
| 号 | 1号 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2017 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| フルテキストURL | esr_024_1_colophon.pdf |
|---|---|
| 著者 | Department of Earth Sciences, Faculty of Science, Okayama University | |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2017-12-27 |
| 巻 | 24巻 |
| 号 | 1号 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2017 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/ESR/56190 |
|---|---|
| タイトル（別表記） | Interdisciplinary class for high school students on the climate environment around Japan and "seasonal feeling" expressed in the school songs with attention to the asymmetric seasonal march from autumn to the next spring |
| フルテキストURL | esr_024_1_005_018.pdf |
| 著者 | 加藤 内藏進| 加藤 晴子| 三宅 昭二| 森 泰三| |
| 抄録 | This study is a part of the activity to develop an interdisciplinary lesson plan for high school students on the climate environment around Japan and the "seasonal feeling". This time, we focused our attention to the asymmetric seasonal march from autumn to the next spring as proposed by Kato et al. (2013). Comparison of the climate between early winter and early spring was made in the class not only on that around the Japan but also on the relation to the larger-scale systems such as the Siberian air mass, including the brief data analysis. The students also compared the detailed "seasonal feeling" between the two seasons expressed in the school songs and the Japanese classic poems called "Wa-Ka". This paper reports the contents and results of this joint activity at the two high schools. |
| キーワード | Interdisciplinary activity on climate and cultural understanding education Climate environment around Japan Seasonal cycle and "seasonal feeling" Asymmetric seasonal march from autumn to the next spring ESD |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2017-12-27 |
| 巻 | 24巻 |
| 号 | 1号 |
| 開始ページ | 5 |
| 終了ページ | 18 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2017 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/ESR/56189 |
|---|---|
| タイトル（別表記） | Rounded pebble of metamorphosed iron-formations from conglomerate of the Miocene deposits in Yatakayama, Kibi Plateau, Okayama Prefecture |
| フルテキストURL | esr_024_1_001_004.pdf |
| 著者 | 鈴木 茂之| 小網, 晴男| 臼井, まゆみ| |
| 抄録 | The Kibi Plateau was a part of the Eurasian Continent and separated by the event of opening of Japan Sea. The rounded pebble which is considered to be continental origin was discovered. The pebble is siliceous and attracts magnets. Prepared thin-sections were observed under microscope. Selected minerals were analyzed by EPMA. The rock is composed of recrystallized quartz, magnetite, riebeckite, stilpnomelane and associated with very tiny minerals with very high relief and interference colors. The assemblage suggests that there is a possibility that the rock is a metamorphic rock of iron-formations and derived from continent. |
| キーワード | Continental origin Miocene conglomerate rounded pebble iron-formations Kibi Plateau |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2017-12-27 |
| 巻 | 24巻 |
| 号 | 1号 |
| 開始ページ | 1 |
| 終了ページ | 4 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2017 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| フルテキストURL | esr_024_1_titlepage.pdf |
|---|---|
| 著者 | Department of Earth Sciences, Faculty of Science, Okayama University | |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2017-12-27 |
| 巻 | 24巻 |
| 号 | 1号 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2017 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| フルテキストURL | esr_024_1_contents_eng.pdf |
|---|---|
| 著者 | Department of Earth Sciences, Faculty of Science, Okayama University | |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2017-12-27 |
| 巻 | 24巻 |
| 号 | 1号 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2017 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/56186 |
|---|---|
| フルテキストURL | 72_4_441.pdf |
| 著者 | Kida, Daihei| Hashimoto, Hiroya| Saito, Akiko M.| Kito, Yukari| Mori, Kouichi| Terabe, Kenya| Takahashi, Nobunori| Tomita, Yasushi| |
| 抄録 | There is no assistive device for extramedullary surgery coordinated with 3D surgical assistive software for the total knee arthroplasty (TKA). We developed a novel extramedullary universal guide coordinated with 3D surgical assistive software and a novel extramedullary patient-specific assistive guide for the placement of femoral components by referring to an area not affected by cartilage or bone spurs, and filed a patent application. In this study, we visualize and reconstruct the total alignment of the lower extremity in TKA using these surgical devices, and validate their precision. A report releasing study results will be submitted in an appropriate journal. |
| キーワード | total knee arthroplasty 3D surgical assistive software tibia femur extramedullary guide |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 441 |
| 終了ページ | 445 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140096 |
| JaLCDOI | 10.18926/AMO/56185 |
|---|---|
| フルテキストURL | 72_4_437.pdf |
| 著者 | Koga, Yuhki| Baba, Shingo| Fukano, Reiji| Nakamura, Katsumasa| Soejima, Toshinori| Maeda, Naoko| Sunami, Shosuke| Ueyama, Junichi| Mitsui, Tetsuo| Mori, Takeshi| Osumi, Tomoo| Sekimizu, Masahiro| Ohki, Kentaro| Tanaka, Fumiko| Kamei, Michi| Fujita, Naoto| Mori, Tetsuya| Saito, Akiko M.| Kada, Akiko| Kobayashi, Ryoji| |
| 抄録 | This trial enrolls patients with untreated Hodgkin’s lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. The outcomes of patients for whom FDG-PET is used to assess early treatment response will also be determined. |
| キーワード | Hodgkin’s lymphoma pediatric fludeoxyglucose positron emission tomography |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 437 |
| 終了ページ | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140095 |
| JaLCDOI | 10.18926/AMO/56184 |
|---|---|
| フルテキストURL | 72_4_431.pdf |
| 著者 | Sekimizu, Masahiro| Osumi, Tomoo| Fukano, Reiji| Koga, Yuhki| Kada, Akiko| Saito, Akiko M.| Mori, Tetsuya| |
| 抄録 | Crizotinib is an inhibitor of multiple tyrosine kinases, including the anaplastic lymphoma kinase (ALK). Responses to crizotinib have also been reported in patients with ALK-positive anaplastic large-cell lymphoma (ALCL) and solid tumors with ALK-mutation, including neuroblastoma. Optimal treatment for patients with recurrent or refractory ALK-positive ALCL and neuroblastoma has not been established. There is a need to develop new drugs for these patients. The objectives of this trial are to evaluate the tolerability and safety of crizotinib in Japanese patients with recurrent/refractory ALK-positive ALCL or neuroblastoma (phase I) and its efficacy in recurrent/refractory ALK-positive ALCL (phase II). |
| キーワード | crizotinib recurrent refractory anaplastic large cell lymphoma neuroblastoma |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 431 |
| 終了ページ | 436 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140094 |
| JaLCDOI | 10.18926/AMO/56183 |
|---|---|
| フルテキストURL | 72_4_427.pdf |
| 著者 | Sekimizu, Masahiro| Fujimoto, Junichiro| Takimoto, Tetsuya| Tsurusawa, Masahito| Horibe, Keizo| Sunami, Shosuke| |
| 抄録 | Pediatric patients with lymphoblastic lymphoma are generally treated using the Berlin-Frankfurt-Munster (BFM) 90 protocol, which is the standard treatment strategy for pediatric acute lymphoblastic leukemia, and have a favorable outcome. However, this intense regimen includes high total doses of anthracycline and alkylating agents, and is known to cause late complications. We therefore planned a clinical trial to examine the efficacy and safety of a modified BFM regimen. We expect that this phase II, nationwide multicenter trial will help to establish an effective and safer standard therapy for stage I/II pediatric lymphoblastic lymphoma. |
| キーワード | pediatrics limited stage lymphoblastic lymphoma efficacy safety |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 427 |
| 終了ページ | 430 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140093 |
| JaLCDOI | 10.18926/AMO/56182 |
|---|---|
| フルテキストURL | 72_4_423.pdf |
| 著者 | Sakakida, Kourin| Wei, Fan-Yan| Senokuchi, Takafumi| Shimoda, Seiya| Kakuma, Tatsuyuki| Araki, Eiichi| Tomizawa, Kazuhito| The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group| |
| 抄録 | Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity. |
| キーワード | diabetes insulin secretion single nucleotide polymorphism glucose |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 423 |
| 終了ページ | 426 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140092 |
| JaLCDOI | 10.18926/AMO/56181 |
|---|---|
| フルテキストURL | 72_4_419.pdf |
| 著者 | Miyake, Susumu| Sugita, Makio| Okazaki, Tomio| Takenaka, Mieko| Kuwabara, Kentarou| Ogawa, Kazunori| |
| 抄録 | A 22-year-old Japanese male with trisomy 21 was diagnosed with West syndrome at 4 months old. After the suppression of epileptic spasms using adrenocorticotropic hormone therapy, he had complex partial seizures and bilateral frontal epileptic discharges on EEG. Although the introduction of topiramate (TPM) decreased the seizures during wakefulness, frequent episodes of brief eye-opening appeared during sleep while the patient was taking TPM (400 mg/day). EEG showed fast activity at the times of eye-opening. The episodes of eye-opening during sleep and the fast activities disappeared upon TPM discontinuation. This is the first report of TPM-induced microseizures similar to benzodiazepine-induced microseizures. |
| キーワード | topiramate microseizures paroxysmal fast activity side effects seizure aggravation |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 419 |
| 終了ページ | 422 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140091 |
| JaLCDOI | 10.18926/AMO/56180 |
|---|---|
| フルテキストURL | 72_4_407.pdf |
| 著者 | Jung, Chanyul| Jung, Suhun| Chun, Min Ho| Lee, Jong Min| Park, Shinsuk| Kim, Seung-Jong| |
| 抄録 | Gait rehabilitation training with robotic exoskeleton is drawing attention as a method for more advanced gait rehabilitation training. However, most of the rehabilitation robots are mainly focused on locomotion training in the sagittal plane. This study introduces a novel gait rehabilitation system with actuated pelvic motion to generate natural gait motion. The rehabilitation robot developed in this study, COWALK, is a lower-body exoskeleton system with 15 degrees of freedom (DoFs). The COWALK can generate multi-DoF pelvic movement along with leg movements. To produce natural gait patterns, the actuation of pelvic movement is essential. In the COWALK, the pelvic movement mechanism is designed to help hemiplegic patients regain gait balance during gait training. To verify the effectiveness of the developed system, the gait patterns with and without pelvic movement were compared to the normal gait on a treadmill. The experimental results show that the active control of pelvic movement combined with the active control of leg movement can make the gait pattern much more natural. |
| キーワード | exoskeleton gait rehabilitation balance control pelvic movement gravity compensation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 407 |
| 終了ページ | 417 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140090 |
| JaLCDOI | 10.18926/AMO/56178 |
|---|---|
| フルテキストURL | 72_4_401.pdf |
| 著者 | Wada, Nozomu| Ikeda, Fusao| Mori, Chizuru| Takaguchi, Koichi| Fujioka, Shin-ichi| Kobashi, Haruhiko| Morimoto, Yoichi| Kariyama, Kazuya| Sakaguchi, Kosaku| Hashimoto, Noriaki| Moriya, Akio| Kawaguchi, Mitsuhiko| Miyatake, Hirokazu| Hagihara, Hiroaki| Kubota, Junichi| Takayama, Hiroki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Takaki, Akinobu| Iwasaki, Yoshiaki| Okada, Hiroyuki| |
| 抄録 | Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR rates than 1B-mono infection (p=0.02). Female sex and RAVs were significant factors associated with treatment failure of this combination therapy for patients with HCV serogroup 1 infection. Mixed HCV infection other than 1B-mono infection would be useful for predicting treatment failure. |
| キーワード | mixed genotype daclatasvir asunaprevir HCV serogrouping 1 infection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 401 |
| 終了ページ | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140089 |
| JaLCDOI | 10.18926/AMO/56177 |
|---|---|
| フルテキストURL | 72_4_395.pdf |
| 著者 | Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Hashimoto, Hiroo| |
| 抄録 | We explored the relationship between sedentary behavior and the health-related quality of life (HRQOL) in patients on chronic hemodialysis. A total of 60 outpatients, aged 71.1±12.0 years, were enrolled in this cross-sectional study. Sedentary behavior was measured using a tri-accelerometer and HRQOL was evaluated by the Euro-QOL questionnaire (EQ-5D). The relationship between the patients’ sedentary behavior and HRQOL was evaluated by simple and multiple correlation analyses. The relative sedentary behavior (%) for total days was 73.7±12.9% and the EQ-5D scores were 0.688±0.233. Relative sedentary behavior (%) was negatively correlated with EQ-5D scores for total days, hemodialysis days and non-hemodialysis days. The relative light-intensity physical activity (LPA) (%) and relative moderately vigorous-intensity physical activity (MVPA) (%) were correlated with EQ-5D scores. Multiple regression showed that the relative sedentary behavior (%) had a clinical impact on EQ-5D scores after adjusting for confounding factors for total, hemodialysis and non-hemodialysis days. Sedentary behavior is closely linked to HRQOL, and reducing sedentary behavior may be beneficial to improve the HRQOL of patients on chronic hemodialysis. |
| キーワード | physical activity sedentary behavior health-related quality of life HRQOL hemodialysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 395 |
| 終了ページ | 400 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140088 |
| JaLCDOI | 10.18926/AMO/56176 |
|---|---|
| フルテキストURL | 72_4_387.pdf |
| 著者 | Hada, Kumiko| Kuse, Emiko| Nakatsuka, Mikiya| |
| 抄録 | To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the controls, but were more likely to worry about losing their baby (58% vs. 38%) (p=0.021). At 3-months postpartum, the RPL group reported having had more stress during pregnancy than the controls (49% vs. 31%; p=0.041). There were no significant differences in state or trait anxiety (State-Trait Anxiety Inventory) between the 2 groups at any of the four measurements. However, state anxiety decreased significantly throughout the hospitalization for controls (p <0.001), but did not decrease significantly for the RPL group until 3 months postpartum (p<0.05). RPL participants who expressed high satisfaction with their partners’ supportive behavior received significantly greater psychological support than did participants with low satisfaction. Healthcare professionals should attempt to support both members of RPL couples. |
| キーワード | recurrent pregnancy loss persistent anxiety supportive behavior of partner psychological support |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 387 |
| 終了ページ | 394 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140087 |
| JaLCDOI | 10.18926/AMO/56175 |
|---|---|
| フルテキストURL | 72_4_379.pdf |
| 著者 | Morizane-Hosokawa, Mio| Morizane, Yuki| Kimura, Shuhei| Shiode, Yusuke| Hirano, Masayuki| Doi, Shinichiro| Toshima, Shinji| Hosogi, Mika| Fujiwara, Atsushi| Shiraga, Fumio| |
| 抄録 | We conducted intravitreal aflibercept injections (IVAs) for 37 Japanese patients (28 males, 9 females, mean age 73.4 years) with polypoidal choroidal vasculopathy (PCV), with a treat-and-extend regimen (TER). We evaluated the impact of polyp regression after a loading dose (2-mg IVA 1×/month for 3 months) on the patients' 2-year treatment outcomes. Thirty-seven eyes were treated with IVA by a TER for 2 years. We divided the patients into 2 groups based on their polyp status after the loading dose: polyp regression (PR+) (n=19) and no polyp regression (PR−) (n=18). We compared the groups’ best-corrected visual acuity (BCVA), central retinal thickness (CRT), recurrence rate, total number of injections, and final treatment interval. Both the BCVA and CRT were significantly improved by the treatment in both groups, with no between-group difference in the amount of change (p=0.769). In the polyp regression (+) group, recurrence was significantly less common (p=0.03), the mean total number of injections was significantly lower (p=0.013), and the mean treatment interval was significantly longer (0.042). Regarding the 2-year outcomes for PCV, the eyes with post-loading-dose polyp regression demonstrated less frequent recurrence and required fewer numbers of injections compared to the eyes without polyp regression. |
| キーワード | polypoidal choroidal vasculopathy aflibercept treat-and-extend regimen polyp regression |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 379 |
| 終了ページ | 385 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140086 |
| JaLCDOI | 10.18926/AMO/56173 |
|---|---|
| フルテキストURL | 72_4_375.pdf |
| 著者 | Morita, Takuya| Sugimoto, Yoshihisa| Takigawa, Tomoyuki| Misawa, Haruo| Ito, Yasuo| Ozaki, Toshifumi| |
| 抄録 | Venous thromboembolism (VTE) is a major complication in patients with acute spinal cord injury. There are few reports of VTE with acute thoracolumbar spinal cord injury (TLSCI). We assessed the incidence of VTE with acute TLSCI using color Doppler ultrasonography. We retrospectively assessed 75 patients with acute TLSCI (T1 to L1). All patients were surgically treated. VTE of the lower extremity and pelvis was assessed using color Doppler ultrasound regardless of whether symptoms were present. This retrospective study included patients who were assessed between 6 and 10 days (mean 8.1 days) after injury. VTE was detected in 27 of the 75 patients (35.7%) with or without paralysis. Of the 13 patients who had complete motor paralysis, 8 (62%) had VTE; of the 31 patients with incomplete motor paralysis, 10 (32%) had VTE, and of the 31 patients without motor paralysis, 9 (29%) had VTE. Among the patients with TLSCI, those with VTE had a significantly higher mean age than those without. The incidence of VTE in TLSCI patients is not related to the severity of paralysis in a Japanese population. The incidence appears to be related primarily to age. |
| キーワード | venous thromboembolism thoracolumbar spinal cord injury paralysis, trauma complication |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 375 |
| 終了ページ | 378 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140085 |
| JaLCDOI | 10.18926/AMO/56172 |
|---|---|
| フルテキストURL | 72_4_369.pdf |
| 著者 | Iwamoto, Takayuki| Taira, Naruto| Fujisawa, Tomomi| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Shien, Tadahiko| Takao, Shintaro| Sato, Masako| Goto, Yoshinari| Yoshida, Takashi| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| |
| 抄録 | The Hormonal therapy resistant estrogen-receptor positive metastatic breast cancer cohort (HORSE-BC) study is a multicenter observational study evaluating the efficacy and safety of secondary endocrine therapy (ET) for postmenopausal cases of metastatic breast cancer (MBC) with poor response to primary ET. In this initial report we analyze the HORSE-BC baseline data to clarify the current status of treatment selection for MBC in Japan. Baseline data for the 50 patients enrolled in HORSE-BC were analyzed, including patient characteristics, types of secondary ET, and reasons for selecting secondary ET. Postoperative recurrence was detected in 84% of patients (42/50) and de novo stage IV breast cancer in 16% (8/50). Forty-one patients (41/50; 82%) received fulvestrant, 5 patients (10%) received selective estrogen receptor modulators (SERMs), 3 patients (6%) received ET plus a mammalian target of rapamycin (mTOR) inhibitor, and 1 patient received an aromatase inhibitor (AI) as the secondary ET. Forty-five patients selected their secondary ET based on its therapeutic effect, while 14 patients selected it based on side effects. Most patients with progression after primary ET selected fulvestrant as the secondary ET based on its therapeutic and side effects. We await the final results from the HORSE-BC study. |
| キーワード | breast cancer secondary endocrine therapy low sensitivity primary endocrine therapy fulvestrant |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 374 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140084 |