検索結果 - 岡山大学学術成果リポジトリ

Clinical Efficacy of Capecitabine and Cyclophosphamide (XC) in Patients with Metastatic Breast Cancer

JaLCDOI	10.18926/AMO/46848
フルテキストURL	65_4_231.pdf
著者	Shien, Tadahiko\| Doihara, Hiroyoshi\| Nishiyama, Keiko\| Masuda, Hiroko\| Nogami, Tomohiro\| Ikeda, Hirokuni\| Taira, Naruto\|
抄録	Combined low-dose therapy of oral capecitabine (Xeloda) and cyclophosphamide (XC) has been demonstrated to be useful for long-term control of lesions in patients with metastatic breast cancer (MBC) and is aimed at symptomatic alleviation and prolongation of survival. Here, a retrospective review was conducted of MBC patients administered XC at the Okayama University Hospital (OUH), to evaluate responses to XC, adverse events and time to progression (TTP). Twenty patients with MBC received XC between 2006 and 2009. With the exception of 2 elderly patients who were over the age of 70 at the initial examination, all of the patients had received prior treatment with an anthracycline and/or a taxane. No complete response (CR) cases were observed, but partial response (PR) was achieved in 6 patients (30%) and SD in 9 (45%), of whom 5 (20%) sustained SD status for >12 months. The median TTP was 6 months (range:3-27 mo.). Three patients developed Grade 3 adverse events (diarrhea, nausea and stomatitis), but no other patients developed adverse reactions causing interruption of the therapy. XC was safe even in previously treated and elderly MBC patients;moreover, it yielded remarkable clinical responses.
キーワード	metastatic breast cancer metronomic chemotherapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	231
終了ページ	237
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860529
Web of Science KeyUT	000294236700003

Postmortem Changes in Myoglobin Content in Organs

JaLCDOI	10.18926/AMO/46847
フルテキストURL	65_4_225.pdf
著者	Miura, Masanobu\| Naka, Toru\| Miyaishi, Satoru\|
抄録	Postmortem changes in myoglobin concentrations in blood and organs were investigated using an enzyme immunoassay by animal experiments in combination with immunohistochemical staining of human cases. Blood myoglobin concentrations were found to increase drastically within a very short time after death. Those in striated muscle, however, did not change by day 14 postmortem. Myoglobin content in the liver and kidney increased slightly by day 5 postmortem, and more obviously by day 7 or later. However, almost no change was observed by day 5 in the kidney when the renal artery and vein had been ligated just after death. In the thyroid gland and the lung, the myoglobin content markedly increased by day 7 postmortem, with the logarithmical values rising nearly linearly as the time after death passed. In the thyroid gland, concentrations reached the level of the striated muscle. The mechanisms of postmortem myoglobin increase in organs are thought to be direct diffusion from the striated muscle and/or distribution through the blood. To estimate the postmortem interval, the determination of myoglobin content in the thyroid gland or the lung appears to be useful.
キーワード	myoglobin postmortem diffusion postmortem distribution postmortem interval
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	225
終了ページ	230
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860528
Web of Science KeyUT	000294236700002

Therapeutic Approaches to Vascular Protection in Ischemic Stroke

JaLCDOI	10.18926/AMO/46846
フルテキストURL	65_4_219.pdf
著者	Yamashita, Toru\| Abe, Koji\|
抄録	Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. We provide an overview of the available scientific reports to improve our understanding of the mechanisms leading to HT, and highlight recent progress in the development of new therapeutic strategies for preventing HT in the post-stroke brain.
キーワード	cerebral ischemia hemorrhagic transformation activator free radical matrix metalloproteinase-9
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	223
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860527
Web of Science KeyUT	000294236700001

Mathematical Modeling of Severe Acute Respiratory Syndrome Nosocomial Transmission in Japan: The Dynamics of Incident Cases and Prevalent Cases

フルテキストURL	MicrobiolImmunol_51_9_823_382.pdf
著者	Fukutome, Ayako\| Watashi, Koichi\| Kawakami, Norito\| Ishikawa, Hirofumi\|
キーワード	SARS Nosocomial transmission Stochastic model Simulation
備考	編集 : 日本細菌学会、日本ウイルス学会、日本免疫学会関連情報 : 岡山大学学位論文学位番号甲第3778号\|
発行日	2007
出版物タイトル	Microbiology and Immunology
巻	51巻
号	9号
出版者	財団法人学会誌刊行センター
開始ページ	823
終了ページ	832
ISSN	0385-5600
NCID	AA00738350
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	17895599
DOI	10.1111/j.1348-0421.2007.tb03978.x
Web of Science KeyUT	000249477100005
オフィシャル URL	http://www.jstage.jst.go.jp/browse/mandi/-char/ja/\|
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/14875

Characterization of an OmpA-like outer membrane protein of the acidophilic iron-oxidizing bacterium, Acidithiobacillus ferrooxidans

著者	Manchur, Mohammed Abul\| Kikumoto, Mei\| Kanao, Tadayoshi\| Takada, Jun\| Kamimura, Kazuo\|
発行日	2011-05
出版物タイトル	Extemophiles
巻	15巻
号	3号
資料タイプ	学術雑誌論文

Thallium-201 Scintigraphy is an Effective Diagnostic Modality to Distinguish Malignant from Benign Soft Tissue Tumors

著者	川上直明\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Icodextrin Increases Technique Survival Rate in Peritoneal Dialysis Patients with Diabetic Nephropathy by Improving Body Fluid Management: A Randomized Controlled Trial

著者	髙取優二\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance

著者	佐藤千景\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis

著者	斎藤大輔\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes

著者	小寺亮\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Intercellular adhesion molecule-1 plays a critical role in glomerulosclerosis after subtotal nephrectomy

著者	城戸雄一\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Alcohol consumption appears to protect against non-alcoholic fatty liver disease

著者	守屋昭男\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Exponential Fitting of Postextrasystolic Potentiation May Underestimate the Cardiac Ca2+ Recirculation Fraction: A Theoretical Analysis

著者	土井ゆみ子\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Quantitative Analysis of DNA Degradation in the Dead Body

著者	井澗美希\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Preclinical Evaluation of Telomerase-Specific Oncolytic Virotherapy for Human Bone and Soft Tissue Sarcomas

著者	佐々木剛\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Early effects of the ex vivo evaluation system on graft function after swine lung transplantation

著者	大谷真二\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Preoperative Graft Volume Assessment with 3D-CT Volumetry in Living-donor Lobar lung Transplantations

著者	児島克英\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling

著者	仁科慎一\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Effects of intermittent high glucose on BeWo choriocarcinoma cells in culture

著者	舛本明生\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery

著者	Taira, Naruto\| Shimozuma, Kojiro\| Shiroiwa, Takeru\| Ohsumi, Shozo\| Kuroi, Katsumasa\| Saji, Shigehira\| Saito, Mitsue\| Iha, Shigemichi\| Watanabe, Takanori\| Katsumata, Noriyuki\|
発行日	2011/08
出版物タイトル	Breast Cancer Research and Treatment
巻	128巻
号	3号
資料タイプ	学術雑誌論文