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JaLCDOI 10.18926/AMO/48268
フルテキストURL 66_2_177.pdf.pdf
著者 Utsumi, Masashi| Matsuda, Hiroaki| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Satoh, Daisuke| Hashimoto, Masaaki| Yagi, Takahito| Fujiwara, Toshiyoshi|
抄録 We report 4 cases of surgical resection of metachronous lymph node (LN) metastases from hepatocellular carcinoma (HCC) following hepatectomy. Clinicopathological features and results of LN dissection were investigated in the 4 patients. One patient was found to have a single metastasis in the mediastinal LNs, another had multiple metastases in the mediastinal and abdominal LNs, and the other 2 had single metastases in the abdominal LN. The locations of the abdominal LN metastases were behind the pancreas head in 2 patients and around the abdominal aorta in 1 patient. They all underwent surgical resection of metastatic LNs and had no postoperative complications. The 3 patients whose LN metastases were solitary have been alive for more than 2 years after LN resection, and one of them is free from recurrence. The patient with multiple LN metastases died 13 months after LN resection due to carcinomatosis. With the expectation of long-term survival, a single metachronous LN metastasis from HCC after hepatectomy should be resected in patients without uncontrollable intrahepatic or extrahepatic tumors.
キーワード hepatocellular carcinoma lymph node metastasis hepatectomy
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 177
終了ページ 182
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525476
Web of Science KeyUT 000303175300011
JaLCDOI 10.18926/AMO/48267
フルテキストURL 66_2_171.pdf.pdf
著者 Masuyama, Hisashi| Nobumoto, Etsuko| Segawa, Tomonori| Hiramatsu, Yuji|
抄録 Preeclampsia may be due to an excess of circulating anti-angiogenic growth factors derived from the placenta, but metabolic syndrome-like disorders may also set off a cascade of placental and systemic inflammation and oxidative stress. We present a case of severe superimposed preeclampsia with obesity, diabetes and a mild imbalance of angiogenic factors, in which diet therapy ameliorated the preeclamptic signs while improving the adiponectin level. A 41-year-old pregnant woman with obesity and diabetes was referred to our hospital because of severe proteinuria and hypertension at 22 weeks of gestation. After administration of insulin and hydralazine with diet therapy, her hypertension and proteinuria were ameliorated with a 15-kg weight loss. Her adiponectin level was low and her leptin level was high, but her angiogenic factor levels were within the normal ranges for pregnant women at admission. The diet therapy ameliorated her hypertension and proteinuria while improving her adiponectin level as she achieved weight loss. This case suggests that diet therapy for obese preeclampsia patients with a mild imbalance of anti-and pro-angiogenic factors may play an important role in managing preeclampsia. Measurements of maternal adipocytokines and angiogenic factors may be important to distinguish the main cause of preeclampsia, i.e., poor placentation or maternal constitutional factors, for managing preeclampsia in patients with obesity.
キーワード adipocytokine angiogenic factor diet therapy obesity preeclampsia
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 171
終了ページ 175
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525475
Web of Science KeyUT 000303175300010
JaLCDOI 10.18926/AMO/48266
フルテキストURL 66_2_163.pdf.pdf
著者 Utsumi, Hiroya| Cabergoline as the Starting Treatment and its Long-term Effects (CASTLE) Study Group|
抄録 Several international studies have suggested that treatment of early Parkinsonʼs disease (PD) with a dopamine agonist instead of levodopa delays the occurrence of motor complications. This 5-year prospective, open, multicenter randomized study aimed to compare the effects of cabergoline on the onset of motor complications with those of levodopa in Japanese patients with early PD. Patients who had never been treated with dopamine agonists or levodopa were enrolled in this study. Four of 45 patients in the cabergoline group and 11 of 46 patients in the levodopa group developed motor complications. The estimated cumulative incidence of motor complications in the cabergoline and levodopa groups was 17オ and 34オ (hazard ratio, 0.57;95オ confidence interval, 0.18‒1.81;p=0.347). Thirty-five adverse events (AEs) were reported in 24 patients in the cabergoline group, while 16 AEs were reported in 13 patients in the levodopa group. Patients in the cabergoline group showed fewer motor complications than did those in the levodopa group, although the difference was not statistically significant. However, the hazard ratio found in this study was similar to those in previous reports.
キーワード cabergoline levodopa Parkinsonʼs disease motor complications
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 163
終了ページ 170
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525474
Web of Science KeyUT 000303175300009
JaLCDOI 10.18926/AMO/48265
フルテキストURL 66_2_155.pdf.pdf
著者 Moriyama, Masahiro| Kawaguchi, Atsuya| Yokokawa, Masaki| Ikeda, Shin| Kitagaki, Hajime| Uchida, Nobue|
抄録 A new hemispherical electrode to heat oral cavity cancer is proposed. The electrode does not produce a hot spot around its edge, a feature that usually arises when using radio frequency (RF) capacitive-type heating. The hemispherical electrode was designed by computer simulation using a 3-D finite element method. To assess its practicality and effectiveness, we built a prototype hemispherical electrode and evaluated its heating characteristics by phantom experiments. The heating effects on the phantom were measured by thermography. The concave phantom surface in contact with the hemispherical electrode showed a uniform increase in temperature, with no obvious edge effect. The proposed electrode allows non-invasive RF capacitive-type heating for intracavity tumors that was not previously considered possible, and should contribute to the multidisciplinary treatment of intracavity tumors.
キーワード radiofrequency heating capacitive-type heating electrode edge effect hemispherical electrode
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 155
終了ページ 162
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525473
Web of Science KeyUT 000303175300008
JaLCDOI 10.18926/AMO/48264
フルテキストURL 66_2_143.pdf.pdf
著者 Watanabe, Makiko| Ueno, Hiroshi| Suemitsu, Shunsuke| Yokobayashi, Eriko| Matsumoto, Yosuke| Usui, Shinichi| Sujiura, Hiroko| Okamoto, Motoi|
抄録 Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
キーワード parvalbumin fast-spiking interneurons FcγRllB barrel cortex sensory deprivation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 143
終了ページ 154
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525472
Web of Science KeyUT 000303175300007
JaLCDOI 10.18926/AMO/48263
フルテキストURL 66_2_131.pdf.pdf
著者 Jia, Lizhong| Kiryu, Shigeru| Watadani, Takeyuki| Akai, Hiroyuki| Yamashita, Hideomi| Akahane, Masaaki| Ohtomo, Kuni|
抄録 Patients with hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombus (PVTT) have an extremely poor prognosis. It is important to select adequate therapeutic options based on reliable prognostic factors using imaging studies and clinical data. Prognostic factors were analyzed in patients with HCC with PVTT in the first branch or main trunk of the portal vein. From 2000 to 2007, 107 consecutive patients with HCC with PVTT in the major portal vein were reviewed, and diagnostic images and clinical characteristics were retrospectively observed. Thirty-eight possible prognostic factors for survival were analyzed by the log-rank test and multivariate analysis using Coxʼs proportional hazards model. Median overall survival was 14 months following PVTT diagnosis. Survival rates at 6 months, 1, 2, and 3 years were 72.1%, 52.6%, 32.6%, and 29.6%, respectively. Independent prognostic factors for longer survival included:patient age <65 years, Child-Pugh classification A/B, PVTT treatment, accumulation of Lipiodol in the PVTT after TACE, initial radical treatment for HCC, HCC located in a single lobe of the liver, and no invasion of HCC to the hepatic vein or bile duct. Survival was associated with liver function, tumor extension, and treatment for HCC and PVTT.
キーワード hepatocellular carcinoma portal vein tumor thrombus prognostic factors
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 131
終了ページ 141
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525471
Web of Science KeyUT 000303175300006
JaLCDOI 10.18926/AMO/48262
フルテキストURL 66_2_119.pdf.pdf
著者 Oka, Hiroaki| Ouchida, Mamoru| Kondo, Takuya| Morita, Fumio| Shimizu, Kenji|
抄録 Human lymphoblastoid TK6 and WTK-1 cells are widely used to detect mutagens in vitro. TK6 cells have wild-type TP53 alleles, while WTK-1 cells have one allele of mutated TP53. Both cells were treated with 5-fluorouracil (5-FU), and gene mutation assay and micronucleus assay were performed to clarify the differential response related to the TP53 gene status. The effects of 5-FU on gene expression were assessed by microarray and quantitative RT-PCR analyses. In WTK-1 cells, 5-FU increased the frequency of cells with micronucleus and mutation. In TK6 cells, frequency of cells with micronucleus was increased but the mutation frequency was not. The cytotoxicity induced by 5-FU was more prominent in TK6 cells than in WTK-1 cells. Analysis of gene expression showed that the genes involved in the TP53 pathway were up-regulated in TK6 cells but not in WTK-1 cells. The differential responses to 5-FU between these cell lines appeared to be due to the difference in the TP53 gene status, thus providing a molecular basis for the bioassays using these cell lines in the toxicology field. Our results indicate that the clinical efficacy of 5-FU chemotherapy may depend on the TP53 genotype.
キーワード 5-fluorouracil TP53 Tk mutation assays microarray analysis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 119
終了ページ 129
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525470
Web of Science KeyUT 000303175300005
JaLCDOI 10.18926/AMO/48261
フルテキストURL 66_2_111.pdf.pdf
著者 Shinomiya, Misae| Kawamura, Kenji| Tanida, Emiko| Nagoshi, Megumi| Motoda, Hirotoshi| Kasanami, Yoshiko| Hiragami, Fukumi| Kano, Yoshio|
抄録 We studied the effects of natural essential oil on neurite outgrowth in PC12m3 neuronal cells to elucidate the mechanism underlying the action of the oils used in aromatherapy. Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. In this study, we investigated whether d-limonene, the major component of essential oils from oranges, can promote neurite outgrowth in PC12m3 cells, in which neurite outgrowth can be induced by various physical stimulations. We also examined by which pathways, the ERK, p38 MAPK or JNK pathway, d-limonene acts on PC12m3 cells. Our results showed that neurite outgrowth can be induced when the cells are treated with d-limonene. After treatment with d-limonene, we observed that p38 MAPK is strongly activated in PC12m3 cells, while ERK is weakly activated. In contrast, JNK shows little activity. A study using an inhibitor of p38 MAPK revealed that neurite outgrowth in PC12m3 cells is induced via the activation of p38 MAPK by d-limonene. The results thus indicate that d-limonene may promote neural cell differentiation mainly via activation of the p38 MAPK pathway.
キーワード essential oil d-limonene p38 MAP kinase PC12 mutant cells
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 111
終了ページ 118
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525469
Web of Science KeyUT 000303175300004
JaLCDOI 10.18926/AMO/48260
フルテキストURL 66_2_101.pdf.pdf
著者 Kishimoto, Fumiko| Ohtsuki, Hiroshi|
抄録 To clarify surgical outcomes for 5 ophthalmic diseases in terms of vision-related quality of life (QOL), we sent a self-administered Visual Function Questionnaire-14 (VF-14) to patients 3 months postoperatively, and the VF-14 scores for the surgical outcome of strabismus were compared with those of patients with diabetic macular edema (DME), cataract, glaucoma, and epiretinal membrane (ERM). Test-retest repeatability of VF-14 was evaluated with Bland-Altman analysis. Of the 625 eligible patients who were referred for enrollment, 48 with comitant strabismus, 50 with incomitant strabismus, 45 with DME, 38 with cataract, 129 with glaucoma, and 73 with ERM agreed to answer. Eighty percent of subjects showed 95オ limits of agreement with the VF-14 evaluated by repeated measurements. The gain by surgery for incomitant strabismus was not different from that of cataract (p=0.5551), but it was significantly better than those of DME (p=0.0266), comitant strabismus (p=0.0128), ERM (p=0.0021), glaucoma with cataract (p<0.0001), and glaucoma alone (p<0.0001). The surgical outcome in terms of QOL for patients with incomitant strabismus was good and comparable to that of patients with cataract surgery.
キーワード visual function questionnaire VF-14 ophthalmic disease surgical intervention gain
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 101
終了ページ 110
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525468
Web of Science KeyUT 000303175300003
JaLCDOI 10.18926/AMO/48259
フルテキストURL 66_2_93.pdf.pdf
著者 Ochiai, Hirotaka| Shirasawa, Takako| Shimada, Naoki| Ohtsu, Tadahiro| Nishimura, Rimei| Morimoto, Aya| Hoshino, Hiromi| Tajima, Naoko| Kokaze, Akatsuki|
抄録 Although a number of studies have investigated the relationship of sleep duration to overweight and obesity, studies conducted among population-based elementary schoolchildren have been limited in Japan. The aim of the present study was to investigate the relationship between sleep duration and overweight among elementary schoolchildren in Japan. The study subjects were all fourth-grade schoolchildren (9 or 10 years of age) in Ina-town, Saitama Prefecture, Japan from 1999 to 2008. Information concerning each subjectʼs sex, age, and lifestyle was obtained using a self-administered questionnaire, while measurements of his or her height and weight were carried out. Childhood overweight was determined according to the definition established by the International Obesity Task Force. Data from 3,433 children were analyzed. In logistic regression analysis, a statistically significant dose-response relationship was observed between sleep duration and overweight among boys (p for trend=0.014) but not among girls (p for trend=0.149). Short sleep duration was associated with childhood overweight, and the sex difference in the association was observed. These findings suggested that it is important to consider sleep duration as part of any program to prevent overweight among elementary schoolchildren, especially among boys.
キーワード sleep overweight schoolchildren Japan
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 93
終了ページ 99
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525467
Web of Science KeyUT 000303175300002
JaLCDOI 10.18926/AMO/48258
フルテキストURL 66_2_83.pdf.pdf
著者 Kuroda, Shinji| Urata, Yasuo| Fujiwara, Toshiyoshi|
抄録 Radiotherapy plays a central part in cancer treatment, and use of radiosensitizing agents can greatly enhance this modality. Although studies have shown that several chemotherapeutic agents have the potential to increase the radiosensitivity of tumor cells, investigators have also studied a number of molecularly targeted agents as radiosensitizers in clinical trials based on reasonably promising preclinical data. Recent intense research into the DNA damage-signaling pathway revealed that ataxia-telangiectasia mutated (ATM) and the Mre11-Rad50-NBS1 (MRN) complex play central roles in DNA repair and cell cycle checkpoints and that these molecules are promising targets for radiosensitization. Researchers recently developed three ATM inhibitors (KU-55933, CGK733, and CP466722) and an MRN complex inhibitor (mirin) and showed that they have great potential as radiosensitizers of tumors in preclinical studies. Additionally, we showed that a telomerase-dependent oncolytic adenovirus that we developed (OBP-301 [telomelysin]) produces profound radiosensitizing effects by inhibiting the MRN complex via the adenoviral E1B55kDa protein. A recent Phase I trial in the United States determined that telomelysin was safe and well tolerated in humans, and this agent is about to be tested in combination with radiotherapy in a clinical trial based on intriguing preclinical data demonstrating that telomelysin and ionizing radiation can potentiate each other. In this review, we highlight the great potential of ATM and MRN complex inhibitors, including telomelysin, as radiosensitizing agents.
キーワード ATM (ataxia-telangiectasia mutated) MRN (Mre11-Rad50-NBS1) complex radiosensitization adenovirus E1B55kDa
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2012-04
66巻
2号
出版者 Okayama University Medical School
開始ページ 83
終了ページ 92
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525466
Web of Science KeyUT 000303175300001
著者 新納 泉|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ その他
著者 今津 勝紀|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 庄 政典|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 新納 泉|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 新納 泉|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 寺村 裕史|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 光本 順|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 新納 泉|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書
著者 野崎 貴博|
発行日 2012-03-30
出版物タイトル 岡山市造山古墳群の調査概報
資料タイプ 研究報告書