Björk-Shiley弁による人工弁置換術後遠隔期の人工弁血栓症及び人工弁最大開放角制限例に対するUrokinase療法 第2編 心エコー図ドプラー法による検討

Urokinase was administrated to 9 patients for the thrombolytic treatment of 10 instances of Bjork-Shiley prosthetic valve thrombosis in the mitral position. Patients were diagnosed either from clinical findings or from the maximum opening angle of the prosthetic valve. Before and after administration of urokinase, Doppler echocardiography was performed in all patients. By means of fibrionlytic treatment, the peak velocity of rapid filling into the left ventricle, the peak pressure gradient, the pressure half time and the mean diastolic gradient decreaed, while the effective valve area increased. It was considered that thrombolytic tretment with urokinase is effective for Bjork-Shiley prosthetic valve thrombosis,