Pathophysiological studies on ferric iron. Part 3. An electronmicroscopic studies on serum iron colloid and some iron preparates

Electron microscopic observations revealed that the serum ferric chloride mixture prepared in the range of pH 5.4 and 8.2 is of colloidal solution whose particles are composed of electron-dense iron colloid nuclei surrounded by protein cortex formed by the absorption around the iron colloid particles. The elevation of pH over 9.0 or the lowering below pH 3 in media results in the loss of the protein cortex enhancing the growth of each molecule to longer ones and to coagulate with each other. Ferritrat proved to have almost the same cortex surrounding the iron colloid as that of serum ferric chloride mixture, but the colloid particles were larger than those of the latter. Both Ferrobalt and the gelatin ferric chloride mixture are of colloid solution but the colloid particles are heterogenous both in size and shape and have no cortex part. Glufericon will be true solution of organic iron complex.