検索結果 47501 件
| フルテキストURL | O0004444_abstract_review.pdf O0004444_fulltext.pdf |
|---|---|
| 著者 | 橘 翔子| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4444号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（学術） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004443_abstract_review.pdf O0004443_fulltext.pdf |
|---|---|
| 著者 | 大久保 和男| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4443号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（農学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004442_abstract_review.pdf O0004442_fulltext.pdf |
|---|---|
| 著者 | 渡邊 正行| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4442号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（農学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004441_abstract_review.pdf O0004441_fulltext.pdf |
|---|---|
| 著者 | Md Tasyrif bin Abdul Rahman| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4441号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | O0004440_abstract_review.pdf O0004440_fulltext.pdf |
|---|---|
| 著者 | 児島 明彦| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4440号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004439_abstract_review.pdf O0004439_fulltext.pdf |
|---|---|
| 著者 | 川﨑 薫| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4439号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004438_abstract_review.pdf O0004438_fulltext.pdf |
|---|---|
| 著者 | 岡本 力| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4438号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004437_abstract_review.pdf O0004437_fulltext.pdf |
|---|---|
| 著者 | 江藤 学| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4437号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004436_abstract_review.pdf O0004436_fulltext.pdf |
|---|---|
| 著者 | 明石 透| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4436号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| フルテキストURL | O0004435_abstract_review.pdf O0004435_fulltext.pdf |
|---|---|
| 著者 | 大隅 淑弘| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 乙第4435号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（工学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |
| JaLCDOI | 10.18926/AMO/53342 |
|---|---|
| フルテキストURL | 69_2_123.pdf |
| 著者 | Waseda, Koichi| Hagiya, Hideharu| Hanayama, Yoshihisa| Terasaka, Tomohiro| Kimura, Kosuke| Tsuzuki, Takao| Hasegawa, Kou| Nada, Takahiro| Nakamura, Eri| Murakami, Kazutoshi| Kondo, Eisei| Otsuka, Fumio| |
| 抄録 | An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients. |
| キーワード | bronchial alveolar lavage eosinophilic pneumonia eosinophilia interstitial lung diseases Sjögren syndrome |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899635 |
| Web of Science KeyUT | 000353181700008 |
| JaLCDOI | 10.18926/AMO/53341 |
|---|---|
| フルテキストURL | 69_2_119.pdf |
| 著者 | Terasaka, Tomohiro| Hagiya, Hideharu| Kimura, Kosuke| Nada, Takahiro| Nakamura, Eri| Hanayama, Yoshihisa| Sugiyama, Hitoshi| Kobayashi, Yasuyuki| Yanai, Hiroyuki| Otsuka, Fumio| |
| 抄録 | We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia. |
| キーワード | catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 119 |
| 終了ページ | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899634 |
| Web of Science KeyUT | 000353181700007 |
| JaLCDOI | 10.18926/AMO/53340 |
|---|---|
| フルテキストURL | 69_2_113.pdf |
| 著者 | Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi| |
| 抄録 | A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control. |
| キーワード | colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 113 |
| 終了ページ | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899633 |
| Web of Science KeyUT | 000353181700006 |
| JaLCDOI | 10.18926/AMO/53339 |
|---|---|
| フルテキストURL | 69_2_105.pdf |
| 著者 | Sawada, Daijo| Ogawa, Takaaki| Miyake, Minoru| Hasui, Yoshinori| Yamaguchi, Fuminori| Izumori, Ken| Tokuda, Masaaki| |
| 抄録 | We examined and compared the inhibitory effects of D-tagatose on the growth, acid production, and water-insoluble glucan synthesis of GS5, a bacterial strain of Streptococcus mutans, with those of xylitol, D-psicose, L-psicose and L-tagatose. GS5 was cultured for 12h in a medium containing 10ｵ (w/v) of xylitol, D-psicose, L-psicose, D-tagatose or L-tagatose, and the inhibitory effect of GS5 growth was assessed. Each sugar showed different inhibitory effects on GS5. Both D-tagatose and xylitol significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1ｵ (w/v) sucrose. However, the inhibitory effect of acid production by D-tagatose was significantly stronger than that of xylitol in presence of sucrose. |
| キーワード | Streptococcus mutans D-tagatose xylitol acid production water-insoluble glucan |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 105 |
| 終了ページ | 111 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899632 |
| Web of Science KeyUT | 000353181700005 |
| JaLCDOI | 10.18926/AMO/53338 |
|---|---|
| フルテキストURL | 69_2_95.pdf |
| 著者 | Lee, Mi Geum| Lee, Dong Kyu| Huh, Billy K.| Choi, Sang Sik| Kim, Hee Zoo| Lim, Byung Gun| Kim, Hong Soon| Choi, Yun Suk| Hur, Won Seok| Lee, Mi Kyoung| |
| 抄録 | Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine－which has been shown to relieve intradermal capsaicin-induced hyperalgesia－on the initial hyperalgesic response and the thermal analgesic property of RTX. Thirty-six male rats were divided into 6 treatment groups (n＝6 each):RTX 500ng, RTX 1μg, clonidine 20μg (Cl), Cl＋RTX 500ng, Cl＋RTX 1μg, or normal saline 20μL (control). We evaluated the short-term (180min) and long-term (20 days) analgesic effects of RTX after thermal stimulation and mechanical stimulation. RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500ng and RTX 1μg groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine. The Cl＋RTX 1μg ratsʼ behavior scores indicated that they were more calm and comfortable compared to the RTX 1μg rats. Even though we cannot precisely confirm that pretreatment with clonidine potentiates or adds to the analgesic effect of RTX, clonidine pretreatment with epidural RTX eliminated the initial RTX-associated hyperalgesic response and systemic toxicity in this neuropathic pain rat model. |
| キーワード | clonidine epidural administration resiniferatoxin spinal nerve ligation rat model thermal hyperalgesia |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 95 |
| 終了ページ | 103 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899631 |
| Web of Science KeyUT | 000353181700004 |
| JaLCDOI | 10.18926/AMO/53337 |
|---|---|
| フルテキストURL | 69_2_87.pdf |
| 著者 | Murayama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Watanabe, Hirokazu| Shigemitsu, Yusuke| Iwasaki, Yuka| Tokorodani, Chiho| Miyazawa, Mari| Nishiuchi, Ritsuo| Kikkawa, Kiyoshi| |
| 抄録 | Ventriculoperitoneal shunts (VPSs) are used for the treatment of hydrocephalus. Here we analyzed the outcomes of VPS placements in 24 infants to determine the risk factors for shunt failure. The infants had undergone the initial VPS operation in our hospital between March 2005 and December 2013. They were observed until the end of January 2014. We obtained Kaplan-Meier curves and performed a multivariate Cox regression analysis of shunt failure. Of the 24 cases, the median (range) values for gestational age, birth weight, and birth head circumference (HC) were 37 (27-39) wks, 2,736 (686-3,788) g, and 35.3 (23.0-45.3) cm, respectively. The total number of shunt procedures was 45. Shunt failure rates were 0.51/shunt and 0.0053/shunt/year. Shunt infection rates were 0.13/shunt and 0.0014/shunt/year. The Kaplan-Meier analysis revealed an increased risk for shunt failure in infants ＜1 month old or in the HC ＞90ｵtile. The Cox regression analysis yielded hazard ratios (HRs) of 2.93 (95ｵ confidence interval (CI), 0.96-10.95, p＝0.059) for age ＜1 month, and 4.46 (95ｵCI:1.20-28.91,p＝0.023) for the HC ＞90ｵtile. The multivariate Cox regression analysis showed adjusted HRs of 17.56 (95ｵCI:2.69-202.8, p＝0.001) for age ＜1 month, and 2.95 (95ｵCI:0.52-24.84, p＝0.228) for the HC ＞90ｵtile. Our findings thus revealed that the risk factors for shunt failure in infants include age ＜1 month at the initial VPS placement. |
| キーワード | head circumference shunt failure shunt infection ventriculoperitoneal shunt |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 87 |
| 終了ページ | 93 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899630 |
| Web of Science KeyUT | 000353181700003 |
| JaLCDOI | 10.18926/AMO/53336 |
|---|---|
| フルテキストURL | 69_2_79.pdf |
| 著者 | Ichimura, Mika| Sasaki, Shinsuke| Mori, Masaharu| Ogino, Tetsuya| |
| 抄録 | This paper investigated whether tapping on the median cubital vein or massaging the forearm was more effective in obtaining better venous palpation for venipuncture. Forty healthy volunteers in their twenties were subjected to tapping (10 times in 5 sec) or massage (10 strokes in 20 sec from the wrist to the cubital fossa) under tourniquet inflation on the upper arm. Venous palpation was assessed using the venous palpation score (0-6, with 0 being impalpable). Three venous factors―venous depth, cross-sectional area, and elevation―were also measured using ultrasonography. The venous palpation score increased significantly by tapping but not by massage. Moreover, all 3 venous measurements changed significantly by tapping, while only the depth decreased significantly by massage. The three venous measurements correlated significantly with the venous palpation score, indicating that they are useful objective indicators for evaluating vasodilation. We suggest that tapping is an effective vasodilation technique. |
| キーワード | massage tapping vasodilation venipuncture venous palpation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 79 |
| 終了ページ | 85 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899629 |
| Web of Science KeyUT | 000353181700002 |
| JaLCDOI | 10.18926/AMO/53335 |
|---|---|
| フルテキストURL | 69_2_71.pdf |
| 著者 | Hiramoto, Hiroki| Dansako, Hiromichi| Takeda, Midori| Satoh, Shinya| Wakita, Takaji| Ikeda, Masanori| Kato, Nobuyuki| |
| 抄録 | Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies. |
| キーワード | HCV annexin A1 Li23 cell line Li23-derived D7 cells HCV-JFH-1 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899628 |
| Web of Science KeyUT | 000353181700001 |
| 著者 | 岡山大学大学院法務研究科| |
|---|---|
| 発行日 | 2015-03 |
| 出版物タイトル | 臨床法務研究 |
| 巻 | 14巻 |
| 資料タイプ | その他 |
| 著者 | 岡山大学大学院法務研究科| |
|---|---|
| 発行日 | 2015-03 |
| 出版物タイトル | 臨床法務研究 |
| 巻 | 14巻 |
| 資料タイプ | その他 |