検索結果 - 岡山大学学術成果リポジトリ

A Randomized Phase 2 Trial of Antibiotic Prophylaxis Versus No Intervention for Muscle Biopsy in A Neurology Department

JaLCDOI	10.18926/AMO/59961
フルテキストURL	74_3_261.pdf
著者	Nakahara, Keiichi\| Ikeda, Tokunori\| Takamatsu, Koutaro\| Tawara, Nozomu\| Hara, Kentaro\| Enokida, Yuki\| Tanoue, Naomi\| Narita, Sawana\| Fujii, Akiko\| Yamanouchi, Yoshinori\| Morinaga, Jun\| Yamashita, Satoshi\|
抄録	Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population.
キーワード	muscle biopsy antibiotic prophylaxis
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	261
終了ページ	264
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577026
Web of Science KeyUT	000543363400011
NAID	120006862802

Intravenous Vitamin C as Ancillary Treatment for Cranial Polyneuritis and Meningitis due to Varicella Zoster Virus Reactivation

JaLCDOI	10.18926/AMO/59960
フルテキストURL	74_3_257.pdf
著者	Hongo, Takashi\| Ikeda, Fusao\| Fujioka, Shinichi\| Akatsuka, Riku\| Fujiwara, Tosifumi\| Yamamoto, Kazuhide\|
抄録	A 65-year-old Japanese woman developed vesicular eruptions on her right ear due to varicella zoster virus (VZV) reactivation, followed by cranial polyneuritis and meningitis affecting her right cranial nerves V, VII, VIII, IX, and X. After acyclovir administration, her facial paralysis worsened. Intravenous methylprednisolone and vitamin C were administered on Day 4 post-admission. Her symptoms steadily improved, and by Day 45 she had fully recovered. Cranial polyneuritis is a rare complication of VZV reactivation, and there is no established method of treatment. This is the first report of full recovery from cranial polyneuritis using intravenous vitamin C as ancillary treatment.
キーワード	varicella zoster virus polyneuritis vitamin C meningitis facial nerve palsy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	257
終了ページ	260
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577025
Web of Science KeyUT	000543363400010
NAID	120006862801

Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20–89 years: A cross-sectional nationwide study in Japan

フルテキストURL	fulltext.pdf
著者	Yamada, Keiko\| Ito, Yoichi M.\| Akagi, Masao\| Chosa, Etsuo\| Fuji, Takeshi\| Hirano, Kenichi\| Ikeda, Shinichi\| Ishibashi, Hideaki\| Ishibashi, Yasuyuki\| Ishijima, Muneaki\| Itoi, Eiji\| Iwasaki, Norimasa\| Izumida, Ryoichi\| Kadoya, Ken\| Kamimura, Masayuki\| Kanaji, Arihiko\| Kato, Hiroyuki\| Kishida, Shunji\| Mashima, Naohiko\| Matsuda, Shuichi\| Matsui, Yasumoto\| Matsunaga, Toshiki\| Miyakoshi, Naohisa\| Mizuta, Hiroshi\| Nakamura, Yutaka\| Nakata, Ken\| Omori, Go\| Osuka, Koji\| Uchio, Yuji\| Ryu, Kazuteru\| Sasaki, Nobuyuki\| Sato, Kimihito\| Senda, Masuo\| Sudo, Akihiro\| Takahira, Naonobu\| Tsumura, Hiroshi\| Yamaguchi, Satoshi\| Yamamoto, Noriaki\| Nakamura, Kozo\| Takashi, Ohe\|
発行日	2020-03-12
出版物タイトル	Journal of Orthopaedic Science
出版者	Elsevier
ISSN	09492658
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	32173180
DOI	10.1016/j.jos.2020.01.011

Evaluation of gadolinium’s action on water Cherenkov detector systems with EGADS

フルテキストURL	fulltext.pdf
著者	Marti, Ll.\| Ikeda, M.\| Kato, Y.\| Kishimoto, Y.\| Nakahata, M.\| Nakajima, Y.\| Nakano, Y.\| Nakayama, S.\| Okajima, Y.\| Orii, A.\| Pronost, G.\| Sekiya, H.\| Shiozawa, M.\| Tanaka, H.\| Ueno, K.\| Yamada, S.\| Yano, T.\| Yokozawa, T.\| Murdoch, M.\| Schuemann, J.\| Vagins, M.R.\| Bays, K.\| Carminati, G.\| Griskevich, N.J.\| Kropp, W.R.\| Locke, S.\| Renshaw, A.\| Smy, M.B.\| Weatherly, P.\| Ito, S.\| Ishino, H.\| Kibayashi, A.\| Koshio, Y.\| Mori, T.\| Sakuda, M.\| Yamaguchi, R.\| Fernandez, P.\| Labarga, L.\| Bandac, I.\| Perez, J.\| Amey, J.\| Litchfield, R.P.\| Sztuc, A.\| Uchida, Y.\| Ma, W.Y.\| Goldsack, A.\| Simpson, C.\| Wark, D.\| Anthony, L.H.V.\| McCauley, N.\| Pritchard, A.\| Di Lodovico, F.\| Richards, B.\| Cole, A.\| Thiesse, M.\| Thompson, L.\| Imber, J.\| Cao, S.V.\| Ito, K.\| Takeuchi, Y.\| Akutsu, R.\| Nishimura, Y.\| Okumura, K.\| Hirota, S.\| Muto, F.\| Yokoyama, M.\| Suda, Y.\| Zhang, H.\|
発行日	2020-04-11
出版物タイトル	Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
巻	959巻
出版者	Elsevier
開始ページ	163549
ISSN	01689002
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors. Published by Elsevier B.V.
論文のバージョン	publisher
DOI	10.1016/j.nima.2020.163549
Web of Science KeyUT	000518368800020
関連URL	isVersionOf 10.1016/j.nima.2020.163549

Regulation of the Poly(A) Status of Mitochondrial mRNA by Poly(A)-Specific Ribonuclease Is Conserved among Land Plants

フルテキストURL	fulltext.pdf
著者	Kanazawa, Mai\| Ikeda, Yoko\| Nishihama, Ryuichi\| Yamaoka, Shohei\| Lee, Nam-Hee\| Yamato, Katsuyuki T\| Kohchi, Takayuk\| Hirayama, Takashi\|
キーワード	Arabidopsis Marchantia polymorpha Mitochondria Poly(A) polymerase Poly(A) regulation Poly(A)-specific ribonuclease
備考	This is a pre-copyedited, author-produced version of an article accepted for publication in Plant and Cell Physiology following peer review. The version of record Mai Kanazawa et. al. Regulation of the Poly(A) Status of Mitochondrial mRNA by Poly(A)-Specific Ribonuclease Is Conserved among Land Plants. Plant and Cell Physiology 61(3), 470–480 (2020) is available online at: https://doi.org/10.1093/pcp/pcz212. \|
発行日	2019-11-13
出版物タイトル	Plant and Cell Physiology
巻	61巻
号	3号
出版者	Oxford University Press
開始ページ	470
終了ページ	480
ISSN	00320781
NCID	AA0077511X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31722408
DOI	10.1093/pcp/pcz212
Web of Science KeyUT	000522855600004
関連URL	isVersionOf https://doi.org/10.1093/pcp/pcz212

Effects of Switching from Treatment with Amlodipine and Atorvastatin Using Two Pills to an Equal Dose of Single-Pill Therapy in Japanese Outpatients

JaLCDOI	10.18926/AMO/58267
フルテキストURL	74_2_103.pdf
著者	Kawada, Yasumasa\| Kubo, Toru\| Baba, Yuichi\| Hirota, Takayoshi\| Tanioka, Katsutoshi\| Yamasaki, Naohito\| Kitaoka, Hiroaki\|
抄録	This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
キーワード	hypertension dyslipidemia single-pill therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	103
終了ページ	108
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341583
Web of Science KeyUT	000528278500002
NAID	120006839446

Development of a method for measuring rare earth elements in the environment for future experiments with gadolinium-loaded detectors

フルテキストURL	fulltext.pdf
著者	Ito, S.\| Okada, T.\| Takaku, Y.\| Harada, M.\| Ikeda, M.\| Kishimoto, Y.\| Koshio, Y.\| Nakahata, M.\| Nakajima, Y.\| Sekiya, H.\|
発行日	2019-06-29
出版物タイトル	Progress of Theoretical and Experimental Physics
号	6号
出版者	Oxford University Press
開始ページ	063H03
ISSN	2050-3911
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019.
論文のバージョン	publisher
DOI	10.1093/ptep/ptz060
Web of Science KeyUT	000482307100015
関連URL	isVersionOf https://doi.org/10.1093/ptep/ptz060

Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy

JaLCDOI	10.18926/AMO/57955
フルテキストURL	74_1_65.pdf
著者	Akiyama, Tomoyuki\| Saigusa, Daisuke\| Hyodo, Yuki\| Umeda, Keiko\| Saijo, Reina\| Koshiba, Seizo\| Kobayashi, Katsuhiro\|
抄録	To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine.
キーワード	antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-02
巻	74巻
号	1号
出版者	Okayama University Medical School
開始ページ	65
終了ページ	72
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32099251
Web of Science KeyUT	000516606200010
NAID	120006795622

Berberine improved experimental chronic colitis by regulating interferon-gamma- and IL-17A-producing lamina propria CD4(+) T cells through AMPK activation

フルテキストURL	SR9_1_11934.pdf
著者	Takahara, Masahiro\| Takaki, Akinobu\| Hiraoka, Sakiko\| Adach, Takuya\| Shimomura, Yasuyuki\| Matsushita, Hiroshi\| Nguyen Tien Thi Thuy\| Koike, Kazuko\| Ikeda, Airi\| Takashima, Shiho\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Sugihara, Yusaku\| Harada, Keita\| Eikawa, Shingo\| Morita, Hidetoshi\| Udono, Heiichiro\| Okada, Hiroyuki\|
発行日	2019-8-15
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	11934
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	31417110
DOI	10.1038/s41598-019-48331-w
Web of Science KeyUT	000480680800048
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-48331-w

Two Cases of High Tibial Osteotomy in Patients with Rheumatoid Arthritis Treated with Biologic Disease-modifying Anti-rheumatic Drugs

JaLCDOI	10.18926/AMO/57720
フルテキストURL	73_6_537.pdf
著者	Takahara, Yasuhiro\| Nishida, Keiichiro\| Nakashima, Hirotaka\| Ochi, Nobuaki\| Uchida, Yoichiro\| Kato, Hisayoshi\| Itani, Satoru\| Nakamura, Makoto\| Iwasaki, Yuichi\| Tsujimura, Yoshitaka\|
抄録	High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty.
キーワード	high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-12
巻	73巻
号	6号
出版者	Okayama University Medical School
開始ページ	537
終了ページ	542
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31871338
Web of Science KeyUT	000503431400011

Risk Factors for Postoperative Hematoma after Chest Wall Contouring for Female-to-Male Transsexuals: A Clinical Study

JaLCDOI	10.18926/AMO/57375
フルテキストURL	73_5_441.pdf
著者	Watanabe, Toshiyuki\| Sakurai, Toru\| Mukai, Yuko\| Kimata, Yoshihiro\| Namba, Yuzaburo\|
抄録	Gender dysphoria is a condition in which a discrepancy between biological sex and gender identity causes distress. Many female-to-male transsexuals (FTMTS) are uncomfortable with female breasts. Chest wall contouring surgery is effective for obtaining a male-type chest, reducing mental stress, and increasing sexual satisfaction in such cases. At the Okayama University Hospital Gender Center, we have obtained positive results using an algorithm to determine the most appropriate surgical method for chest wall contouring in FTMTS patients. However, serious complications requiring reoperation, such as hematoma, may still occur. Postoperative hematomas were found in 15 (4.18%) of 358 FTMTS patients who underwent chest contouring surgery at our hospital between 2006 and 2018. Postoperative hematoma was examined retrospectively. The median time to the onset of hematoma was 7 (6-12) h after the initial surgery. The main blood vessels causing bleeding were those in the head-side skin flap region where visual confirmation was difficult and the perforator vessels from the pectoralis major muscle. Intraoperative bleeding and the operation time had a significant impact on the onset of postoperative hematoma. This is the first retrospective study that investigated the blood vessels and other factors contributing to postoperative hematoma development after chest wall contouring.
キーワード	female-to-male transsexuals chest wall contouring postoperative hematoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	441
終了ページ	447
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649371
Web of Science KeyUT	000491886600010

Comparison of Two Different Drugs for Overactive Bladder, Solifenacin and Mirabegron: A Prospective Randomized Crossover Study

JaLCDOI	10.18926/AMO/57368
フルテキストURL	73_5_387.pdf
著者	Inoue, Miyabi\| Yokoyama, Teruhiko\|
抄録	To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of solifenacin in both groups. The OABSS significantly improved in both groups after 4 weeks. In group M, the OABSS after eight weeks was significantly improved compared to that after 4 weeks. However, in group S, it was not significantly improved. Twelve patients experienced adverse events during the solifenacin treatment, while 2 patients experienced adverse events during the mirabegron treatment. Both solifenacin and mirabegron led to improved OAB symptoms. Switching from mirabegron to solifenacin significantly improved the OABSS. However, mirabegron led to fewer adverse events than solifenacin. We recommend that mirabegron be prescribed first for OAB patients. If patients are not satisfied with mirabegron, solifenacin should be used.
キーワード	overactive bladder, randomized crossover study solifenacin mirabegron
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	387
終了ページ	392
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649364
Web of Science KeyUT	000491886600003

A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis

JaLCDOI	10.18926/AMO/56940
フルテキストURL	73_4_367.pdf
著者	Mifune-Morioka, Tomoyo\| A. Uchida, Haruhito\| Fukushima, Kazuhiko\| Watanabe, Mayu\| Ouchi, Chihiro\| Mise, Koki\| Kawakita, Chieko\| Kano, Yuzuki\| Onishi, Akifumi\| Toma, Kishio\| Eguchi, Jun\| Wada, Nozomu\| Ikeda, Fusao\| Sasaki, Erika\| Suganami, Yu\| Kishida, Masayuki\| Sugiyama, Hitoshi\| Okada, Hiroyuki\| Wada, Jun\|
抄録	Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
キーワード	autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	367
終了ページ	372
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439961

The Efficacy and Safety of Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/56935
フルテキストURL	73_4_333.pdf
著者	Kuwaki, Kenji\| Nouso, Kazuhiro\| Miyashita, Manabi\| Makino, Yasuhiro\| Hagihara, Hiroaki\| Moriya, Akio\| Adachi, Takuya\| Wada, Nozomu\| Yasunaka, Yuki\| Yasunaka, Tetsuya\| Takeuchi, Yasuto\| Onishi, Hideki\| Nakamura, Shinichiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Okada, Hiroyuki\|
抄録	Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.
キーワード	antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	339
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439956

Conventional-dose Versus Half-dose Sulfamethoxazole-trimethoprim for the Prophylaxis of Pneumocystis Pneumonia in Patients with Systemic Rheumatic Disease: A Non-blind, Randomized Controlled Trial

JaLCDOI	10.18926/AMO/56464
フルテキストURL	73_1_85.pdf
著者	Abe, Yoshiyuki\| Fujibayashi, Kazutoshi\| Nishizaki, Yuji\| Yanagisawa, Naotake\| Nojiri, Shuko\| Nakano, Soichiro\| Tada, Kurisu\| Yamaji, Ken\| Tamura, Naoto\|
抄録	Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy.
キーワード	pneumocystis pneumonia prophylaxis systemic rheumatic disease sulfamethoxazole-trimethoprim conventional-dose versus half-dose
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	85
終了ページ	89
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820060

Comparison of Two Electrosurgical Modes for Endoscopic Submucosal Dissection of Superficial Colorectal Neoplasms: A Prospective Randomized Study

JaLCDOI	10.18926/AMO/56463
フルテキストURL	73_1_81.pdf
著者	Sugihara, Yuusaku\| Harada, Keita\| Oka, Shohei\| Yasutomi, Eriko\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Takahara, Masahiro\| Hiraoka, Sakiko\| Otsuka, Fumio\| Okada, Hiroyuki\|
抄録	Endoscopic submucosal dissection (ESD) is reportedly one of the standard treatment strategies for large superficial colorectal neoplasms in Japan because of its high en bloc resection rate. A few technical issues regarding ESD should be considered, one of which is the selection of the Endo-cut I mode versus the Swift-coagulation mode as the electrosurgical unit mode setting during submucosal dissection. We seek to determine which of these two modes is more suitable for submucosal dissections of colorectal tumors with regard to procedure time and safety.
キーワード	endoscopic submucosal dissection electrosurgical mode colorectal tumor
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	81
終了ページ	84
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820059

Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation

JaLCDOI	10.18926/AMO/56457
フルテキストURL	73_1_43.pdf
著者	Ikeda, Ailee\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Onishi, Hideki\| Ikeda, Fusao\| Shiraha, Hidenori\| Yoshida, Kazuhiro\| Kuise, Takashi\| Nobuoka, Daisuke\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Okada, Hiroyuki\|
抄録	Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses.
キーワード	acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	41
終了ページ	50
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820053

Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage

JaLCDOI	10.18926/AMO/56456
フルテキストURL	73_1_29.pdf
著者	Matsumoto, Atsushi\| Nakamura, Takehiro\| Shinomiya, Aya\| Kawakita, Kenya\| Kawanishi, Masahiko\| Miyake, Keisuke\| Kuroda, Yasuhiro\| Keep, Richard F.\| Tamiya, Takashi\|
抄録	Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
キーワード	biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	29
終了ページ	39
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820052

Clitoral Blood Flow Changes after Surgery with Tension-Free Vaginal Mesh for Pelvic Organ Prolapse

JaLCDOI	10.18926/AMO/56455
フルテキストURL	73_1_21.pdf
著者	Oiwa, Yuko\| Watanabe, Toyohiko\| Sadahira, Takuya\| Ishii, Ayano\| Sako, Tomoko\| Inoue, Miyabi\| Wada, Koichiro\| Kobayashi, Yasuyuki\| Araki, Motoo\| Nasu, Yasutomo\|
抄録	We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2±7.9 at baseline to 18.2±8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction.
キーワード	clitoris pelvic organ prolapse Doppler ultrasound
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	21
終了ページ	27
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820051

The Role of Kallikrein-Related Peptidases in Atopic Dermatitis

JaLCDOI	10.18926/AMO/56452
フルテキストURL	73_1_1.pdf
著者	Morizane, Shin\|
抄録	Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD.
キーワード	atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	6
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820048