憂うつ病の身体症状 内分泌を中心として

1) 憂うつ病の身体的徴候を特に内分泌所見を中心として考察した. 2) 憂うつ状態では尿の17-KS分劃が減少し,血清の17-OHCS分劃の増加が見られる.憂うつ症にTestosterone系のものを与えると症状が改善したり,又ACTH注射やCortisol投与で悪化する事実から,憂うつ状態の成立には性腺系ホルモンの減少が関係していると考えられる. 3) 憂うつ病になる者には性腺系ホルモン代謝に潜在的な弱点があるのではなかろうかと思われる.

1. Investigation was made on the patients with melancholia about their somatic conditions with special reference to the endocrine system. 2. As a result it has been found that in melancholia 17-KS fraction in urine is. decreased while serum 17-OHCS fraction is increased. Moreover, since the administration of androsterone or its series improves general conditions in melancholia and ACTH injection or cortisol medication aggravates the conditions, it is assumed that the decrease in sex hormones is responsible for the development of melancholia. 3. Those who are predisposed to melancholia seem to have latent weakness in the sex hormone metabolisms.