検索結果 - 岡山大学学術成果リポジトリ

若手・中堅耳鼻咽喉科医師の臨床研究に対する質問紙調査

タイトル（別表記）	Questionnaire survey of junior and mid-career otolaryngologists' attitudes towards clinical research
著者	浦口健介\| 頼藤貴志\| 高尾総司\| 菅谷明子\| 安藤瑞生\|
抄録	Introduction : Clinical research is crucial for the advancement of medicine, but modern otolaryngologists' attitudes regarding clinical research have not been known. This study was conducted to survey the background, knowledge, and interest in clinical research among junior and mid-career otolaryngologists. 　Methods : A questionnaire survey was distributed to 34 otolaryngologists with ≤15 years' clinical experience working at Okayama University and its affiliated facilities. The respondents were divided into junior (non-specialists) and mid-career otolaryngologists (specialists) based on whether they were board-certified otolaryngologists. The survey assessed their background, understanding, and interest in clinical research. 　Results : Twenty-nine otolaryngologists (83%) responded (10 junior and 19 mid-career otolaryngologists). There was significant individual variation in their interest and knowledge of clinical research. However, approximately half of the respondents indicated that they were not interested in and/or had never engaged in clinical research. 　Conclusion : The data collected by this survey contribute to our understanding of the current state of clinical research engagement among junior and mid-career otolaryngologists, and they can serve as a basis for exploring future strategies to increase this engagement.
キーワード	臨床研究 (clinical research) 統計解析 (statistical analysis) ビッグデータ (bigdata) 質問紙調査 (questionnaire survey)
出版物タイトル	岡山医学会雑誌
発行日	2025-04-01
巻	137巻
号	1号
開始ページ	20
終了ページ	24
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.137.20
言語	日本語
著作権者	Copyright (c) 2025 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.137.20

臓器創造・移植医療の可能性と展望

タイトル（別表記）	The potential and prospects of organ generation medicine
著者	森宗昌\|
キーワード	organ generation regeneration bioengineering
出版物タイトル	岡山医学会雑誌
発行日	2025-04-01
巻	137巻
号	1号
開始ページ	15
終了ページ	19
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.137.15
言語	日本語
著作権者	Copyright (c) 2025 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.137.15

新生児期・小児発症の希少遺伝性疾患の病態解明とゲノム解析の社会実装に向けて

タイトル（別表記）	Understanding the pathogenesis of rare monogenic disorders and the social implementation of genomic medicine
著者	武内俊樹\|
キーワード	病態解明希少遺伝性疾患社会実装
出版物タイトル	岡山医学会雑誌
発行日	2025-04-01
巻	137巻
号	1号
開始ページ	10
終了ページ	14
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.137.10
言語	日本語
著作権者	Copyright (c) 2025 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.137.10

Olanzapine enabled rechallenge after lorlatinib-induced psychosis: A case report

フルテキストURL	fulltext.pdf
著者	Yokode, Akiyoshi\| Fujiwara, Masaki\| Nakamura, Yuko\| Ohashi, Kadoaki\| Sakamoto, Shinji\| Takaki, Manabu\|
キーワード	psycho-oncology lorlatinib lung cancer medication-induced psychosis
発行日	2025-04-27
出版物タイトル	Psychiatry and Clinical Neurosciences Reports
巻	4巻
号	2号
出版者	Wiley
開始ページ	e70091
ISSN	2769-2558
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s).
論文のバージョン	publisher
PubMed ID	40291168
DOI	10.1002/pcn5.70091
Web of Science KeyUT	001476913400001
関連URL	isVersionOf https://doi.org/10.1002/pcn5.70091

令和５年度岡山医学会賞　がん研究奨励賞（林原賞・山田賞）

タイトル（別表記）	The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize)
著者	浦田知宏\|
出版物タイトル	岡山医学会雑誌
発行日	2025-04-01
巻	137巻
号	1号
開始ページ	7
終了ページ	9
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.137.7
言語	日本語
著作権者	Copyright (c) 2025 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.137.7

令和５年度岡山医学会賞　総合研究奨励賞（結城賞）

タイトル（別表記）	The 2023 Incentive Award of the Okayama Medical Association in General Medical Science (2023 Yuuki Prize)
著者	住居優一\|
出版物タイトル	岡山医学会雑誌
発行日	2025-04-01
巻	137巻
号	1号
開始ページ	4
終了ページ	6
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.137.4
言語	日本語
著作権者	Copyright (c) 2025 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.137.4

令和５年度岡山医学会賞　脳神経研究奨励賞（新見賞）

タイトル（別表記）	The 2023 Incentive Award of the Okayama Medical Association in Neuroscience (2023 Niimi Prize)
著者	竹之下慎太郎\|
出版物タイトル	岡山医学会雑誌
発行日	2025-04-01
巻	137巻
号	1号
開始ページ	1
終了ページ	3
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.137.1
言語	日本語
著作権者	Copyright (c) 2025 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.137.1

A mini-hairpin shaped nascent peptide blocks translation termination by a distinct mechanism

フルテキストURL	fulltext.pdf
著者	Ando, Yushin\| Kobo, Akinao\| Niwa, Tatsuya\| Yamakawa, Ayako\| Konoma, Suzuna\| Kobayashi, Yuki\| Nureki, Osamu\| Taguchi, Hideki\| Itoh, Yuzuru\| Chadani, Yuhei\|
発行日	2025-03-08
出版物タイトル	Nature Communications
巻	16巻
号	1号
出版者	Nature Portfolio
開始ページ	2323
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025
論文のバージョン	publisher
PubMed ID	40057501
DOI	10.1038/s41467-025-57659-z
Web of Science KeyUT	001462675700032
関連URL	isVersionOf https://doi.org/10.1038/s41467-025-57659-z

Effect Modification in Settings with “Truncation by Death”

著者	Gonçalves, Bronner P.\| Suzuki, Etsuji\|
キーワード	Causal inference Effect modification Principal stratification Transportability
備考	This is a non-final version of an article published in final form in Gonçalves, Bronner P.a; Suzuki, Etsujib,c. Effect Modification in Settings with “Truncation by Death”. Epidemiology 36(3):p 374-380, May 2025. \| DOI: 10.1097/EDE.0000000000001834.\| This fulltext file will be available in May 2026.\|
発行日	2025-05
出版物タイトル	Epidemiology
巻	36巻
号	3号
出版者	Ovid Technologies (Wolters Kluwer Health)
開始ページ	374
終了ページ	380
ISSN	1044-3983
NCID	AA10832184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 Wolters Kluwer Health, Inc.
論文のバージョン	author
PubMed ID	39855255
DOI	10.1097/ede.0000000000001834
Web of Science KeyUT	001465446900002
関連URL	isVersionOf https://doi.org/10.1097/ede.0000000000001834

Anticoagulant effects of edoxaban in cancer and noncancer patients with venous thromboembolism

フルテキストURL	fulltext.pdf
著者	Yoshida, Masashi\| Ejiri, Kentaro\| Matsuo, Naoaki\| Naito, Takanori\| Kuroda, Kazuhiro\| Tokioka, Koji\| Hatanaka, Kunihiko\| Fujimoto, Ryohei\| Yamaoka, Hidenaru\| Kajikawa, Yutaka\| Suruga, Kazuki\| Sugiyama, Hiroki\| Miyaji, Tsuyoshi\| Morimoto, Yoshimasa\| Okamura, Nobuhiro\| Sarashina, Toshihiro\| Akagi, Satoshi\| Miyoshi, Toru\| Nakamura, Kazufumi\| Ito, Hiroshi\| Yuasa, Shinsuke\|
キーワード	Factor Xa inhibitors Anticoagulation effects Cancer Venous thromboembolism
発行日	2025-04-16
出版物タイトル	Thrombosis Journal
巻	23巻
号	1号
出版者	BMC
開始ページ	36
ISSN	1477-9560
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	40241057
DOI	10.1186/s12959-025-00720-0
Web of Science KeyUT	001469332700001
関連URL	isVersionOf https://doi.org/10.1186/s12959-025-00720-0

Safe Resection of Esophageal Cancer with a Non-Recurrent Inferior Laryngeal Nerve Associated with an Aberrant Right Subclavian Artery Using Intraoperative Nerve Monitoring

JaLCDOI	10.18926/AMO/68654
フルテキストURL	79_2_139.pdf
著者	Takeda, Yasushige\| Noma, Kazuhiro\| Maeda, Naoaki\| Mizusawa, Yohei\| Matsumoto, Hijiri\| Kondo, Yuhei\| Kunitomo, Tomoyoshi\| Tanoue, Yukinori\| Hashimoto, Masashi\| Tanabe, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	In thoracic esophageal cancer, lymph node dissection around the recurrent laryngeal nerve is crucial but poses a risk of nerve palsy, affecting postoperative quality of life. In cases with an aberrant right subclavian artery (ARSA), the right recurrent laryngeal nerve is absent, and the non-recurrent inferior laryngeal nerve (NRILN) enters the larynx directly from the vagus nerve in the cervical region. Identifying the course of the NRILN is vital to avoid injury. A case of esophageal cancer with an ARSA, in which the course of the NRILN was preserved using the Nerve Integrity Monitoring (NIM) system during surgery, is described.
キーワード	esophageal cancer intraoperative nerve monitoring aberrant right subclavian artery non-recurrent inferior laryngeal nerve thoracoscopic esophagectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	139
終了ページ	144
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302287
Web of Science KeyUT	001485501900001

Calcified Amorphous Tumor of the Left Ventricle with Paroxysmal Atrial Fibrillation

JaLCDOI	10.18926/AMO/68653
フルテキストURL	79_2_135.pdf
著者	Fujita, Yasufumi\| Shimizu, Shuji\| Mohri, Makoto\|
抄録	Cardiac calcified amorphous tumor (CAT) is a rare, benign non-neoplastic mass of the heart that is sometimes found due to embolic events. Most cases of CAT are treated with surgical removal to prevent future embolic events. However, the treatment strategy for CAT complicated by atrial fibrillation has remained to be determined. Here we report a case of left ventricular CAT complicated by paroxysmal atrial fibrillation (PAF) that was successfully treated with surgical removal and pulmonary vein isolation. Pulmonary vein isolation can be a simple and effective procedure for PAF, even during surgical removal of CAT.
キーワード	calcified amorphous tumor surgical removal embolic stroke paroxysmal atrial fibrillation pulmonary vein isolation
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	135
終了ページ	138
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302286
Web of Science KeyUT	001485501000001

A Case of Retinitis Pigmentosa Diagnosed with Severe Anterior Capsule Contraction after Cataract Surgery

JaLCDOI	10.18926/AMO/68652
フルテキストURL	79_2_129.pdf
著者	Tsuji, Akihiro\| Shiode, Yusuke\| Kimura, Shuhei\| Hosokawa, Mio\| Matoba, Ryo\| Morita, Tetsuro\| Takahashi, Kosuke\| Morizane, Yuki\|
抄録	A 66-year-old woman presented with significant anterior capsule contraction and intraocular lens dislocation in both eyes 4 months after cataract surgery. Postoperative examinations such as fluorescein angiography, Goldmann perimetry, and electroretinography revealed retinitis pigmentosa (RP). Patients with significant anterior capsule contraction after cataract surgery should be closely examined because RP may be a contributing factor.
キーワード	retinitis pigmentosa intraocular lens anterior capsule contraction
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	129
終了ページ	134
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302285
Web of Science KeyUT	001485535700001

Macular Hole Formation Six Months after Hemorrhage Displacement for Submacular and Henle Fiber Layer Hemorrhage due to Retinal Arterial Macroaneurysm Rupture

JaLCDOI	10.18926/AMO/68651
フルテキストURL	79_2_123.pdf
著者	Akatsuka, Riku\| Kimura, Shuhei\| Matoba, Ryo\| Morizane Hosokawa, Mio\| Shiode, Yusuke\| Morita, Tetsuro\| Doi, Shinichiro\| Morizane, Yuki\|
抄録	A 78-year-old woman presented with sudden vision loss and central scotoma. Visual acuity in the right eye was 20/222, with submacular hemorrhage (SMH) and Henle fiber layer hemorrhage (HFLh) due to retinal arterial macroaneurysm (RAM) rupture. She underwent SMH displacement, including cataract surgery, vitrectomy, intravitreal injection of tissue-plasminogen activator, and air tamponade. Three months postoperatively the SMH and HFLh had disappeared and visual acuity had improved to 20/200. Six months postoperatively, a macular hole had developed. We performed an inverted internal limiting membrane flap and gas tamponade. Ten months later, the hole had closed and visual acuity had improved to 20/100.
キーワード	submacular hemorrhage Henle fiber layer hemorrhage retinal arterial macroaneurysm rupture macular hole inverted internal limiting membrane flap technique
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	127
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302284
Web of Science KeyUT	001485544200008

From a Congenital Defect to Cancer: A Case of Squamous Cell Carcinoma in a Neglected Myelomeningocele

JaLCDOI	10.18926/AMO/68650
フルテキストURL	79_2_117.pdf
著者	Gautam, Abhishek\| Kenawadekar, Rahul\| Hattiholi, Virupaxi\| Maste, Praful Suresh\|
抄録	Neural tube defects are common congenital anomalies, typically presenting early due to visible swelling and/or neurological deficits. Rarely, cystic swellings are neglected until adulthood, with only 14 cases of malignancy developing in an untreated meningomyelocele reported to date. We describe the case details of a 26-year-old Indian woman with this rare complication. Magnetic resonance imaging revealed a low-lying spinal cord with spinal dysraphism, cord herniation, and a cystic lesion. The biopsy confirmed a well-differentiated squamous cell carcinoma. Malignant transformation in an untreated myelomeningocele is rare, with chronic irritation and infection as proposed causes. Early biopsy and treatment are crucial for its management.
キーワード	squamous cell carcinoma meningomyelocele occult spinal dysraphism
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	117
終了ページ	121
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302283
Web of Science KeyUT	001485544200007

Relationship between Personality Traits and Postpartum Depressive Symptoms in Women who Became Pregnant via Infertility Treatment

JaLCDOI	10.18926/AMO/68649
フルテキストURL	79_2_109.pdf
著者	Awai, Kyoko\| Nakatsuka, Mikiya\|
抄録	The status of postpartum depression was elucidated herein with the use of the Edinburgh Postnatal Depression Scale (EPDS) in women in Shikoku, Japan who became pregnant and gave birth after undergoing infertility treatment, including assisted reproductive technology (ART). The assessment was performed during their children’s 4-month health examination. The relationships between postpartum depression and the mothers’ background factors and scores on the Big Five personality traits scale were also examined. Of the Big Five personality traits, the scores for neuroticism were significantly higher in the ART group (n=71) than in the general infertility treatment (n=118) and natural pregnancy (n=872) groups. No significant differences in EPDS scores were seen among these three groups. A logistic regression analysis showed that neuroticism was associated with an EPDS score ≧9 points, (which is suggestive of postpartum depression, ) in all groups. Moreover, although a long-standing marriage had an inhibitory effect on postpartum depression in the natural pregnancy group, no such trend was seen in the ART group, which included many women with long-standing marriages. Particularly for women who become pregnant by ART, an individualized response that pays close attention to the woman’s personality traits is needed.
キーワード	infertility treatment assisted reproductive technology postpartum postpartum depression personality trait
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	109
終了ページ	116
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302282
Web of Science KeyUT	001485544200006

Effectiveness of Postoperative Irradiation in Patients with cN0 Early Breast Cancer Treated with Sentinel Lymph Node Surgery

JaLCDOI	10.18926/AMO/68648
フルテキストURL	79_2_101.pdf
著者	Isozaki, Hiroshi\| Matsumoto, Sasau\| Takama, Takehiro\| Isozaki, Yuka\|
抄録	To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes.
キーワード	breast cancer postoperative irradiation radiation therapy sentinel lymph nodes recurrence
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	101
終了ページ	107
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302281
Web of Science KeyUT	001485544200005

Lower Work Engagement Is Associated with Insomnia, Psychological Distress, and Neck Pain among Junior and Senior High School Teachers in Japan

JaLCDOI	10.18926/AMO/68647
フルテキストURL	79_2_093.pdf
著者	Tsuchie, Rina\| Fukuda, Mari\| Tsumura, Hideki\| Kinuta, Minako\| Hisamatsu, Takashi\| Kanda, Hideyuki\|
抄録	School teachers are subject to both physical and mental health problems. We examined cross-sectional relationships between work engagement and major health outcomes among junior and senior high school teachers in Japan via a nationwide survey in 2019-2020. A total of 3,160 respondents were included in the analyses (19.9% response rate). Work engagement was assessed with the Utrecht Work Engagement Scale-9 (UWES-9), and we thus divided the teachers into quartiles according to their UWES-9 scores. Based on validated questionnaires, we assessed insomnia, psychological distress, and neck pain as health outcomes. A binomial logistic regression adjusted for age, gender, school type, teacher’s roles, involvement in club activities, division of duties, employment status, and whether they lived with family demonstrated that the teachers with lower UWES-9 scores had higher burdens of insomnia, psychological distress, and neck pain (odds ratios [95% confidence intervals] in 4th vs. 1st quartile, 2.92 (2.34-3.65), 3.70 (2.81-4.88), and 2.12 (1.68-2.68), respectively; all trend p<0.001). There were no significant differences in these associations between full-time and part-time teachers. Our findings indicate that low work engagement may contribute to physical and mental health issues among junior and senior high school teachers, thus providing insights for preventing health problems in this profession.
キーワード	work engagement school teachers insomnia psychological distress neck pain
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	93
終了ページ	100
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302280
Web of Science KeyUT	001485544200004

Clinical Outcomes of Neoadjuvant Paclitaxel/Cisplatin/Gemcitabine Compared with Gemcitabine/Cisplatin for Muscle-Invasive Bladder Cancer

JaLCDOI	10.18926/AMO/68646
フルテキストURL	79_2_081.pdf
著者	Kawada, Tatsushi\| Kobayashi, Yasuyuki\| Tsugawa, Takuji\| Tsuboi, Kazuma\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Kobayashi, Tomoko\| Edamura, Kohei\| Ebara, Shin\| Araki, Motoo\|
抄録	We retrospectively evaluated the oncologic outcomes of paclitaxel, cisplatin, and gemcitabine (PCG) with those of gemcitabine and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients. The primary outcome was efficacy: pathological complete response (pCR), ypT0N0; and pathological objective response (pOR), ypT0N0, ≤ ypT1N0, or ypT0N1. Secondary outcomes included overall survival (OS), recurrence-free survival (RFS), predictive factors for pOR, OS, and RFS, and hematologic adverse events (AEs). Among 113 patients treated (PCG, n=28; GC, n=85), similar pOR and pCR rates were achieved by the groups (pOR: PCG, 57.1% vs. GC, 49. 4%; p=0.52; pCR: PCG, 39.3% vs. GC, 29.4%; p=0.36). No significant differences were observed in OS (p=1.0) or RFS (p=0.20). Multivariate logistic regression analysis showed that hydronephrosis (odds ratio [OR] 0.32, 95%CI: 0.11-0.92) and clinical node-positive status (cN+) (OR 0.22, 95%CI: 0.050-0.99) were significantly associated with a decreased probability of pOR. On multivariate Cox regression analyses, pOR achievement was associated with improved OS (hazard ratio [HR] 0.23, 95%CI: 0.10-0.56) and RFS (HR 0.30, 95%CI: 0.13-0.67). There were no significant between-group differences in the incidence of grade ≥ 3 hematologic AEs or dose-reduction required, but the PCG group had a higher incidence of grade 4 neutropenia.
キーワード	urothelial carcinoma paclitaxel cisplatin gemcitabine neoadjuvant
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	81
終了ページ	92
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302279
Web of Science KeyUT	001485544200003

Potential for Radiation Dose Reduction in Temporal Bone CT Imaging Using Photon-Counting Detector CT

JaLCDOI	10.18926/AMO/68645
フルテキストURL	79_2_075.pdf
著者	Higaki, Fumiyo\| Morimitsu, Yusuke\| Iguchi, Toshihiro\| Hwang, Sung Il\| Kitayama, Takahiro\| Takahashi, Yuka\| Uka, Mayu\| Akagi, Noriaki\| Sugaya, Akiko\| Mitsuhashi, Toshiharu\| Matsui, Yusuke\| Hiraki, Takao\|
抄録	Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%.
キーワード	computed tomography photon-counting detector computed tomography ear ossicle energy-integrating detector computed tomography
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	75
終了ページ	80
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40302278
Web of Science KeyUT	001485544200002