検索結果 - 岡山大学学術成果リポジトリ

Preoperative Graft Volume Assessment with 3D-CT Volumetry in Living-Donor Lobar Lung Transplantations

JaLCDOI	10.18926/AMO/46852
フルテキストURL	65_4_265.pdf
著者	Kojima, Katsuhide\| Kato, Katsuya\| Oto, Takahiro\| Mitsuhashi, Toshiharu\| Shinya, Takayoshi\| Sei, Tetsuro\| Okumura, Yoshihiro\| Sato, Shuhei\| Miyoshi, Shinichiro\| Kanazawa, Susumu\|
抄録	To determine the effectiveness of living-donor lobar lung transplantation (LDLLT), it is necessary to predict the recipient's postoperative lung function. Traditionally, Date's formula, also called the segmental ratio, has used the number of lung segments to estimate the forced vital capacity (FVC) of grafts in LDLLT. To provide a more precise estimate of graft FVC, we calculated the volumes of the lower lobe and total lung using three-dimensional computed tomography (3D-CT) and the volume ratio between them. We calculated the volume ratio in 52 donors and tested the difference between the segmental volume ratios with a one-tailed t-test. We also calculated the predicted graft FVC in 21 LDLLTs using the segmental ratio pFVC(c) and the volume ratio pFVC(v), and then found the Pearson's correlation coefficients for both pFVC(c) and pFVC(v) with the recipients' actual FVC (rFVC) measured spirometrically 6 months after surgery. Significant differences were found between the segmental ratio and the average volume ratio for both sides (right, p＝0.03;left, p＝0.0003). Both pFVC(c) and pFVC(v) correlated significantly with rFVC at 6 months after surgery (p＝0.007 and 0.006). Both the conventional and the volumetric methods provided FVC predictions that correlated significantly with measured postoperative FVC.
キーワード	living-donor lobar lung transplantation 3D-CT volumetry
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	265
終了ページ	268
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860533
Web of Science KeyUT	000294236700007

Is Adenosine Deaminase in Pleural Fluid a Useful Marker for Differentiating Tuberculosis from Lung Cancer or Mesothelioma in Japan, a Country with Intermediate Incidence of Tuberculosis?

JaLCDOI	10.18926/AMO/46851
フルテキストURL	65_4_259.pdf
著者	Ogata, Yoshiko\| Aoe, Keisuke\| Hiraki, Akio\| Murakami, Kazuo\| Kishino, Daizo\| Chikamori, Kenichi\| Maeda, Tadashi\| Ueoka, Hiroshi\| Kiura, Katsuyuki\| Tanimoto, Mitsune\|
抄録	The objective of this study was to evaluate the utility of the determination of adenosine deaminase (ADA) level in pleural fluid for the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) in Japan, a country with intermediate incidence of tuberculosis (TB). We retrospectively reviewed the clinical records of 435 patients with pleural effusion and investigated their pleural ADA levels as determined by an auto analyzer. ROC analysis was also performed. The study included patients with MPE (n＝188), TPE (n＝124), benign nontuberculous pleural effusion (n＝94), and pleural effusion of unknown etiology (n＝29). The median ADA level in the TPE group was 70.8U/L, which was significantly higher than that in any other groups (p＜0.05). The area under the curve (AUC) in ROC analysis was 0.895. With a cut-off level for ADA of 36U/L, the sensitivity, specificity, positive predictive value, and negative predictive value were 85.5%, 86.5%, 69.7%, and 93.6%, respectively. As many as 9% of patients with lung cancer and 15% of those with mesothelioma were false-positive with this ADA cutoff setting. Although the ADA activity in pleural fluid can help in the diagnosis of TPE, it should be noted that some cases of lung cancer or mesothelioma show high ADA activity in geographical regions with intermediate incidence of TB, in contrast to high prevalence areas.
キーワード	pleural effusion adenosine deaminase tuberculosis lung cancer mesothelioma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	259
終了ページ	263
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860532
Web of Science KeyUT	000294236700006

Carotid Endarterectomy for Symptomatic Complete Occlusion of the Internal Carotid Artery

JaLCDOI	10.18926/AMO/46849
フルテキストURL	65_4_239.pdf
著者	Cho, Yong-Pil\| Kwon, Tae-Won\| Kwon, Sun U.\| Chae, Won-Young\| Kim, Geun-Eun\|
抄録	We described 9 consecutive patients who underwent operative carotid artery exploration with attempted carotid endarterectomy (CEA) for symptomatic internal carotid artery (ICA) occlusion. Indications for this surgery based on vascular imaging included segmental occlusion of the proximal ICA and also extensive occlusion of the distal ICA in selected patients in whom color-flow duplex ultrasound showed a poorly echogenic or anechoic thrombus with a flow void, suggestive of an acute thrombus. CEA was performed successfully to restore blood flow in all 9 patients:CEA in 5 and CEA with Fogarty thrombectomy in 4. Postoperative magnetic resonance (MR) angiography confirmed that revascularization had been successful in all 9 patients, and MR imaging displayed improved perfusion in 4 patients. Despite the lack of a generalized efficacy of surgical revascularization for symptomatic ICA occlusion, our study demonstrated that preoperative vascular imaging allows the selection of patients who may benefit from CEA.
キーワード	internal carotid artery occlusion carotid endarterectomy vascular imaging
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	239
終了ページ	245
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860530
Web of Science KeyUT	000294236700004

Clinical Efficacy of Capecitabine and Cyclophosphamide (XC) in Patients with Metastatic Breast Cancer

JaLCDOI	10.18926/AMO/46848
フルテキストURL	65_4_231.pdf
著者	Shien, Tadahiko\| Doihara, Hiroyoshi\| Nishiyama, Keiko\| Masuda, Hiroko\| Nogami, Tomohiro\| Ikeda, Hirokuni\| Taira, Naruto\|
抄録	Combined low-dose therapy of oral capecitabine (Xeloda) and cyclophosphamide (XC) has been demonstrated to be useful for long-term control of lesions in patients with metastatic breast cancer (MBC) and is aimed at symptomatic alleviation and prolongation of survival. Here, a retrospective review was conducted of MBC patients administered XC at the Okayama University Hospital (OUH), to evaluate responses to XC, adverse events and time to progression (TTP). Twenty patients with MBC received XC between 2006 and 2009. With the exception of 2 elderly patients who were over the age of 70 at the initial examination, all of the patients had received prior treatment with an anthracycline and/or a taxane. No complete response (CR) cases were observed, but partial response (PR) was achieved in 6 patients (30%) and SD in 9 (45%), of whom 5 (20%) sustained SD status for >12 months. The median TTP was 6 months (range:3-27 mo.). Three patients developed Grade 3 adverse events (diarrhea, nausea and stomatitis), but no other patients developed adverse reactions causing interruption of the therapy. XC was safe even in previously treated and elderly MBC patients;moreover, it yielded remarkable clinical responses.
キーワード	metastatic breast cancer metronomic chemotherapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	231
終了ページ	237
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860529
Web of Science KeyUT	000294236700003

Postmortem Changes in Myoglobin Content in Organs

JaLCDOI	10.18926/AMO/46847
フルテキストURL	65_4_225.pdf
著者	Miura, Masanobu\| Naka, Toru\| Miyaishi, Satoru\|
抄録	Postmortem changes in myoglobin concentrations in blood and organs were investigated using an enzyme immunoassay by animal experiments in combination with immunohistochemical staining of human cases. Blood myoglobin concentrations were found to increase drastically within a very short time after death. Those in striated muscle, however, did not change by day 14 postmortem. Myoglobin content in the liver and kidney increased slightly by day 5 postmortem, and more obviously by day 7 or later. However, almost no change was observed by day 5 in the kidney when the renal artery and vein had been ligated just after death. In the thyroid gland and the lung, the myoglobin content markedly increased by day 7 postmortem, with the logarithmical values rising nearly linearly as the time after death passed. In the thyroid gland, concentrations reached the level of the striated muscle. The mechanisms of postmortem myoglobin increase in organs are thought to be direct diffusion from the striated muscle and/or distribution through the blood. To estimate the postmortem interval, the determination of myoglobin content in the thyroid gland or the lung appears to be useful.
キーワード	myoglobin postmortem diffusion postmortem distribution postmortem interval
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	225
終了ページ	230
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860528
Web of Science KeyUT	000294236700002

Therapeutic Approaches to Vascular Protection in Ischemic Stroke

JaLCDOI	10.18926/AMO/46846
フルテキストURL	65_4_219.pdf
著者	Yamashita, Toru\| Abe, Koji\|
抄録	Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. We provide an overview of the available scientific reports to improve our understanding of the mechanisms leading to HT, and highlight recent progress in the development of new therapeutic strategies for preventing HT in the post-stroke brain.
キーワード	cerebral ischemia hemorrhagic transformation activator free radical matrix metalloproteinase-9
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2011-08
巻	65巻
号	4号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	223
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21860527
Web of Science KeyUT	000294236700001

Mathematical Modeling of Severe Acute Respiratory Syndrome Nosocomial Transmission in Japan: The Dynamics of Incident Cases and Prevalent Cases

フルテキストURL	MicrobiolImmunol_51_9_823_382.pdf
著者	Fukutome, Ayako\| Watashi, Koichi\| Kawakami, Norito\| Ishikawa, Hirofumi\|
キーワード	SARS Nosocomial transmission Stochastic model Simulation
備考	編集 : 日本細菌学会、日本ウイルス学会、日本免疫学会関連情報 : 岡山大学学位論文学位番号甲第3778号\|
発行日	2007
出版物タイトル	Microbiology and Immunology
巻	51巻
号	9号
出版者	財団法人学会誌刊行センター
開始ページ	823
終了ページ	832
ISSN	0385-5600
NCID	AA00738350
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	17895599
DOI	10.1111/j.1348-0421.2007.tb03978.x
Web of Science KeyUT	000249477100005
オフィシャル URL	http://www.jstage.jst.go.jp/browse/mandi/-char/ja/\|
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/14875

Characterization of an OmpA-like outer membrane protein of the acidophilic iron-oxidizing bacterium, Acidithiobacillus ferrooxidans

著者	Manchur, Mohammed Abul\| Kikumoto, Mei\| Kanao, Tadayoshi\| Takada, Jun\| Kamimura, Kazuo\|
発行日	2011-05
出版物タイトル	Extemophiles
巻	15巻
号	3号
資料タイプ	学術雑誌論文

Icodextrin Increases Technique Survival Rate in Peritoneal Dialysis Patients with Diabetic Nephropathy by Improving Body Fluid Management: A Randomized Controlled Trial

著者	髙取優二\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis

著者	斎藤大輔\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes

著者	小寺亮\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Intercellular adhesion molecule-1 plays a critical role in glomerulosclerosis after subtotal nephrectomy

著者	城戸雄一\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Exponential Fitting of Postextrasystolic Potentiation May Underestimate the Cardiac Ca2+ Recirculation Fraction: A Theoretical Analysis

著者	土井ゆみ子\|
発行日	2011-06-30
出版物タイトル
資料タイプ	学位論文

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery

著者	Taira, Naruto\| Shimozuma, Kojiro\| Shiroiwa, Takeru\| Ohsumi, Shozo\| Kuroi, Katsumasa\| Saji, Shigehira\| Saito, Mitsue\| Iha, Shigemichi\| Watanabe, Takanori\| Katsumata, Noriyuki\|
発行日	2011/08
出版物タイトル	Breast Cancer Research and Treatment
巻	128巻
号	3号
資料タイプ	学術雑誌論文

Cut loci and conjugate loci on Liouville surfaces

著者	Itoh, Jin-ichi\| Kiyohara, Kazuyoshi\|
発行日	2011/09
出版物タイトル	Manuscripta Mathematica
巻	136巻
号	1-2号
資料タイプ	学術雑誌論文

心筋梗塞の二次予防戦略

著者	河野晋久\|
発行日	2011-08-01
出版物タイトル	岡山医学会雑誌
巻	123巻
号	2号
資料タイプ	学術雑誌論文

上腕骨外側上顆炎の診療ガイドライン

著者	島村安則\| 井上円加\| 小澤正嗣\| 金澤智子\| 斎藤太一\| 中原龍一\| 野田知之\| 西田圭一郎\| 尾﨑敏文\|
発行日	2011-08-01
出版物タイトル	岡山医学会雑誌
巻	123巻
号	2号
資料タイプ	学術雑誌論文

早期胃癌に対する内視鏡的粘膜下層剥離術後に急性胃蜂窩織炎を併発した１例

著者	西江学\| 岩川和秀\| 濱野亮輔\| 徳永尚之\| 常光洋輔\| 大塚真哉\| 稲垣優\| 岩垣博巳\| 合原大博\| 藤田勲生\| 村上敬子\| 友田純\|
発行日	2011-08-01
出版物タイトル	岡山医学会雑誌
巻	123巻
号	2号
資料タイプ	学術雑誌論文

腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例

著者	西江学\| 大塚真哉\| 友田純\| 藤原敬士\|
発行日	2011-08-01
出版物タイトル	岡山医学会雑誌
巻	123巻
号	2号
資料タイプ	学術雑誌論文

医療訴訟における「医師の説明」に関する研究

著者	福本良之\|
発行日	2011-08-01
出版物タイトル	岡山医学会雑誌
巻	123巻
号	2号
資料タイプ	学術雑誌論文