抗原捕捉免疫測定法による抗アシアロ糖タンパク質受容体抗体の検出 ―自己免疫性肝疾患における臨床的意義―

In the development of autoimmune chronic acive hepatitis (AIH), the pathogenic relevance of antimmune responses against asialoglycoprotein recepter (ASGPR) has been implicated. We have previously developed a capture enzyme-linked immunsorbent assay (ELISA) for detection of anti-ASGPR antibodies and found a high prevalence of anti-ASGPR antibodies in AIH and primary biliary cirrhosis (PBC). IN this study, to clarify the clinical singnifi-cance of the measurement of anti-ASGPR antibodies in autimmune live diseases we studied correlations between thee isotype of the anti-ASGPR antibody.In AIH, the anti-ASGPR antibody titer was positively correlated with serum γ-globulin and IgM values, but not with serum transaminase. The anti-ASGPR antibody titer in histogically-active disease with piecmeal necrosis was signififcantly higher then that in quiescent disease. The most common Isotype of anti-ASGPR antibodies detected in active AIH was IgM. We encountered a case of AIH where the tirer of IgM anti-ASGPR antibody decreased by induction of remission with steroid therapy. These results suggest that the measurement of IgM isotope anti-ASGPR antiody might be useful for the evaluation of disease activity and effects of therapy in AIH patients.

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