大量フェンタニールによる単純超低体温麻酔時の循環動態と血中カテコラミン濃度に関する実験的研究

Six adult dogs were anesthetized by deep hypothermia with a combination high dose fentanyl and PGE1 (F group). The circulatory system and blood catecholamine concentration were determined. Another 6 adult dogs were anesthetized by deep hypothermia with a combination ether and PEG1 (E group) for a comparison with the F group. Before cooling under anesthesia, the PAP, PVRI and Pp/Ps showed a significant difference in the E group. During cooling, the MAP was 74% and 56% of the control values in the F and E groups, respectively and there were significant differences between the F and E groups. The peak dp/dt/IP was significantly different between the F and E groups at the lowest temperature (46% and 27% of the conrol values, respectively). The CI was 34% and 25% of control values at the lowest temperature in both groups. EP or NE did not significantly increase during cooling or rewarming in the F group. The EP had a tendency to increase during rewarming and NE significantly increased in comparison with the control values during cooling and warming in the E group. Combination anesthesia with high dose fentanyl and PGE1 inhibits the circulatory systems to a lesser degree, resulting in easier maintenance of the circulatory system. This combination system is also more stable than that with ether and PGE1 or with ether and TFP.