| ID | 14252 |
| Eprint ID | 14252
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| フルテキストURL | |
| タイトル（別表記） | Studies on platelet function in bronchial asthma Part 2. Production of 12-hydroxyeicosatetraenoic acid from platelets and the platelet-lymphocyte interaction in bronchial asthmatics
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| 著者 |
角南 宏二
岡山大学医学部第二内科学教室
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| 抄録 | To clarify the role of platelets in the pathogenesis of bronchial asthma, the production of 12-hydroxyeicosatetraenoic acid(12HETE) from platelets of asthmatics was examined by high performance liquid chromatography(HPLC). The effect of platelets on lymphocyte function was also studied by lymphocyte blastogenesis. The results were as follows : 1) The production of 12HETE from platelets of asthmatics were significantly higher than that of normal subjects(p<0.01). 2) Blastogenesis of lymphocytes was significantly suppressed by addition of platelets(p<0.05). 3) Blastogenesis of lymphocytes was significantly suppressed by addition of more than 12.5ng/ml of 12HETE, 10ng/ml of transforming growth factorβ(TGE-β) or 50ng/ml of serotonin.
These results suggest that platelets play an important role in the pathogenesis of asthmatic responses mediated by activated lymphocytes.
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| キーワード | platelet
bronchial asthma
12HETE
lymphocyte
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| 備考 | 原著
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| 発行日 | 1992-12
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 104巻
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| 号 | 11-12号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 1079
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| 終了ページ | 1086
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/104/11-12/104_11-12_1079/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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