検索結果 68 件
| フルテキストURL | fulltext20220128-2.pdf |
|---|---|
| 著者 | Khan, Rizwan| Nishina, Yuta| |
| 備考 | This is an accepted manuscript published by The Royal Society of Chemistry. This fulltext is available in Dec. 2022.| |
| 発行日 | 2022 |
| 出版物タイトル | Dalton Transactions |
| 巻 | 51巻 |
| 号 | 5号 |
| 出版者 | Royal Society of Chemistry (RSC) |
| 開始ページ | 1874 |
| 終了ページ | 1878 |
| ISSN | 1477-9226 |
| NCID | AA11810256 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Royal Society of Chemistry 2022 |
| 論文のバージョン | author |
| PubMed ID | 35018910 |
| DOI | 10.1039/d1dt03197j |
| Web of Science KeyUT | 000741529400001 |
| 関連URL | isVersionOf https://doi.org/10.1039/d1dt03197j |
| JaLCDOI | 10.18926/AMO/62813 |
|---|---|
| フルテキストURL | 75_6_725.pdf |
| 著者 | Matsumoto, Hiroshi| Kimata, Yoshihiro| Ota, Tomoyuki| Sugiyama, Narushi| Onoda, Satoshi| Makino, Takuma| Takeda, Seiko| Mizukawa, Nobuyoshi| |
| 抄録 | The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up. |
| キーワード | skin flap mucosal flap oral reconstruction morphological change second primary carcinoma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 725 |
| 終了ページ | 734 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955541 |
| NAID | 120007180279 |
| JaLCDOI | 10.18926/AMO/62772 |
|---|---|
| フルテキストURL | 75_5_595.pdf |
| 著者 | Imai, Norio| Endo, Naoto| Suda, Ken| Suzuki, Hayato| |
| 抄録 | Multidisciplinary approaches such as fracture liaison services (FLS) have been introduced in some countries to reduce medical complications and secondary fractures in patients with fragility hip fracture. We aimed to investigate outcomes in patients with fragility hip fracture following the introduction of FLS. Patients > 50 years old who experienced fragility hip fractures between January 1, 2015 and December 31, 2017 were enrolled, and divided into a control group (without FLS; 94 patients) and FLS group (373 patients). We found that the time from injury to surgery decreased significantly from 2.42 to 1.83 days (p = 0.003), the proportion of patients who underwent surgery within 36 h of injury increased significantly (p = 0.014), and the number of cases with complications after admission decreased significantly (p = 0.004) in the FLS group. Patients with a Barthel index ≥ 80 were more common in the FLS than the control group at 6 , 12, and 24 months following injury (p = 0.046 , 0.018, and 0.048, respectively). Multiple logistic regression analysis revealed the factors associated with postoperative complications and death within 12 or 24 months after injury. Our results indicate that FLS contributed to earlier recovery, rehabilitation following surgery and rehabilitation of medical complications following admission; improved patient activity; and decreased secondary hip fractures. |
| キーワード | postoperative complications fracture liaison services hip fractures multidisciplinary approaches |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 595 |
| 終了ページ | 600 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703042 |
| Web of Science KeyUT | 000711561600006 |
| NAID | 120007166672 |
| JaLCDOI | 10.18926/AMO/62408 |
|---|---|
| フルテキストURL | 75_4_533.pdf |
| 著者 | Tsuchie, Hiroyuki| Miyakoshi, Naohisa| Nagasawa, Hiroyuki| Shimada, Yoichi| |
| 抄録 | Tumor lysis syndrome (TLS) is a complication of cancer treatment that requires urgent intervention. It is extremely rare in the treatment of soft tissue sarcoma (STS) of the limbs or trunk, and there are currently no reports of TLS occurrence from eribulin therapy. We report the case of a 78-year-old woman with an undiffer-entiated pleomorphic sarcoma on the right buttock. We initiated chemotherapy with intravenous eribulin mesylate. Deterioration of renal function, mild hyperkalemia, hyperuricemia, hypocalcemia, and hyperphos-phatemia were confirmed on examination, suggesting the presence of TLS. We present an extremely rare case of TLS from eribulin for STS. |
| キーワード | tumor lysis syndrome eribulin soft tissue sarcoma cancer chemotherapy metastasis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 533 |
| 終了ページ | 538 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511623 |
| Web of Science KeyUT | 000696755800002 |
| NAID | 120007146034 |
| フルテキストURL | Arch Virol, HadV1-1NL_Manuscript SUZUKI.pdf |
|---|---|
| 著者 | Khan, Haris Ahmed| Sato, Yukiyo| Kondo, Hideki| Jamal, Atif| Bhatti, Muhammad Faraz| Suzuki, Nobuhiro| |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00705-021-05176-x| |
| 発行日 | 2021-7-27 |
| 出版物タイトル | Archives of Virology |
| 巻 | 166巻 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 2711 |
| 終了ページ | 2722 |
| ISSN | 0304-8608 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Springer Nature Switzerland AG |
| 論文のバージョン | author |
| PubMed ID | 34313859 |
| DOI | 10.1007/s00705-021-05176-x |
| Web of Science KeyUT | 000678003000001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00705-021-05176-x |
| フルテキストURL | K0006408_abstract_review.pdf K0006408_fultext.pdf |
|---|---|
| 著者 | RIZWAN, KHAN| |
| 発行日 | 2021-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6408号 |
| 学位授与年月日 | 2021-03-25 |
| 学位・専攻分野 | 博士（学術） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/61906 |
|---|---|
| フルテキストURL | 75_2_231.pdf |
| 著者 | Endo, Motochika| Yano, Shuya| Asano, Hiroaki| Takeda, Sho| Hamada, Yuki| Kondo, Yoshitaka| Kuroda, Shinji| Shigeyasu, Kunitoshi| Kikuchi, Satoru| Tanaka, Takehiro| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma. |
| キーワード | primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 231 |
| 終了ページ | 238 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953431 |
| NAID | 120007029881 |
| JaLCDOI | 10.18926/AMO/61902 |
|---|---|
| フルテキストURL | 75_2_205.pdf |
| 著者 | Hoshijima, Mitsuhiro| Kawanabe, Noriaki| Iida, Seiji| Yamashiro, Takashi| Kamioka, Hiroshi| |
| 抄録 | We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar “cigarette-paper” scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS. |
| キーワード | asymmetry Class II camouflage orthodontic anchor screw Ehlers-Danlos syndrome |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 205 |
| 終了ページ | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953427 |
| NAID | 120007029885 |
| JaLCDOI | 10.18926/AMO/61877 |
|---|---|
| フルテキストURL | 75_2_115.pdf |
| 著者 | Hitomi, Nishizaki| Yoshinari, Morimoto| Yamada, Shin-ichi| Kurita, Hiroshi| Tanaka, Akira| Yamaguchi, Akira| Miyata, Masaru| Yoshikawa, Hiromasa | Yanamoto, Souichi| Imai, Yutaka| |
| 抄録 | The aim of this study was to investigate the awareness and experience, among dental practitioners, of adverse events resulting from dental treatment of patients undergoing therapy with drugs that affect the immune system [angiogenesis inhibitors, biological agents, immunosuppressants, and disease-modifying anti-rheumatic drugs (DMARDs)]. For this purpose, a nationwide questionnaire survey was conducted. Questionnaires were sent to 2,050 dentists, of which 206 (10.1%) were completed and returned. The results showed that most dentists were aware of complications associated with dental treatment of patients treated with drugs that affect the immune system, and about half had actually experienced such complications. Delayed wound healing, osteonecrosis of the jaw (ONJ), and postoperative infections were reported. Whereas approximately 50% of dentists did not discontinue the drugs during dental treatment, about 18% did. During temporary drug discontinuation, some patients experienced aggravation of the primary disease, such as worsening of rheumatism, growth of tumors, and rejection reactions of transplanted organs. As for medical cooperation, only less than half of the dentists were asked for oral hygiene management by a physician prior to starting the drug treatment. Prospective studies are needed because evidence for dental treatments in patients treated with these drugs remains limited. |
| キーワード | angiogenesis inhibitor biological agent disease-modifying antirheumatic drug (DMARD) immunosuppressant medication-related osteonecrosis of the jaw (MRONJ) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-04 |
| 巻 | 75巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 123 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33953417 |
| NAID | 120007029906 |
| JaLCDOI | 10.18926/AMO/61432 |
|---|---|
| フルテキストURL | 75_1_39.pdf |
| 著者 | Akezaki, Yoshiteru| Nakata, Eiji| Kikuuchi, Masato| Tominaga, Ritsuko| Kurokawa, Hideaki| Hamada, Makiko| Aogi, Kenjiro| Ohsumi, Shozo| Sugihara, Shinsuke| |
| 抄録 | In this study, we examined whether axillary web syndrome (AWS) in patients with breast cancer following axil-lary lymph node dissection affects range of motion (ROM), upper extremity function, and quality of life (QOL). The risk factors for AWS were also evaluated in a total of 238 consecutive breast cancer patients follow-ing axillary lymph node dissection. At 1, 2, and 3 months after surgery, there were no significant differences between the AWS group and the non-AWS group in upper-limb function or QOL. At 2 months after surgery, shoulder flexion and abduction ROM were significantly higher in the AWS group than in the non-AWS group (p < 0.05). Self-training time at home was not significantly different between the groups at 1, 2, or 3 months. Only age was a significant predictor of AWS at 1 month after surgery (p < 0.05). The AWS group in the present study did not have worse results for shoulder joint ROM, upper-limb function, and QOL than the non-AWS group. Younger age should be useful for predicting the development of AWS in the early postoperative period. |
| キーワード | breast cancer axillary web syndrome age upper limb function quality of life |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-02 |
| 巻 | 75巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 39 |
| 終了ページ | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33649612 |
| JaLCDOI | 10.18926/AMO/61209 |
|---|---|
| フルテキストURL | 74_6_495.pdf |
| 著者 | Calliope, Simba Akintije| Yorifuji, Takashi| Wada, Takayuki| Mukakarake, Marie Goret| Mutesa, Leon| Yamamoto, Taro| |
| 抄録 | In many economically developing countries, and especially in the rural regions of sub-Saharan African coun-tries, there have been only limited investigations into the association between antenatal care (ANC) and adverse pregnancy outcomes. We obtained information on ANC and pregnancy outcomes between 2011 and 2016 from hospital files of pregnant women (n = 4,960) served at a rural hospital in Rwanda, and we examined the associa-tions between their ANC visits and the adverse pregnancy and neonatal outcomes by using univariate and mul-tivariate logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Most of the pregnant women had ≥ 4 ANC visits, but 39% (n = 1,911) did not have ≥ 3 visits before delivery. The prev-alence of low birth weight (LBW) and that of preterm birth (PTB) were 12% and 9.9%, respectively. Compared to the women who attended only one ANC visit, those who attended ≥ 4 ANC visits had lower risks of LBW (OR 0.20; 95%CI: 0.11-0.36) and PTB (OR 0.28; 95%CI: 0.11-0.76). Frequent ANC visits were also associ-ated with better postnatal outcomes of the newborns. Encouraging women to attend ANC visits before delivery can markedly reduce PTB-related and LBW-related complications, especially in resource-limited settings. |
| キーワード | antenatal care epidemiology low birth weight preterm birth rural |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-12 |
| 巻 | 74巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 495 |
| 終了ページ | 503 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33361869 |
| Web of Science KeyUT | 000601203600005 |
| NAID | 120006948958 |
| JaLCDOI | 10.18926/AMO/60801 |
|---|---|
| フルテキストURL | 74_5_415.pdf |
| 著者 | Narihiro, Naomasa| Oita, Masataka| Takeda, Yoshihiro| |
| 抄録 | During radiation therapy, incident radiation oblique to the skin surface is high and may cause severe skin damage. Understanding the dose of radiation absorbed by the skin is important for predicting skin damage due to radiation. In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new equation in which the oblique surface dose can be calculated within the error range of −7.7-5.1%. |
| キーワード | optically stimulated luminescent dosimeter radiotherapy oblique surface dose high-energy X-ray therapy angular dependence |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 415 |
| 終了ページ | 422 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106697 |
| Web of Science KeyUT | 000581970100006 |
| NAID | 120006892927 |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| フルテキストURL | 74_5_371.pdf |
| 著者 | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| 抄録 | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| キーワード | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 371 |
| 終了ページ | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
| JaLCDOI | 10.18926/AMO/59961 |
|---|---|
| フルテキストURL | 74_3_261.pdf |
| 著者 | Nakahara, Keiichi| Ikeda, Tokunori| Takamatsu, Koutaro| Tawara, Nozomu| Hara, Kentaro| Enokida, Yuki| Tanoue, Naomi| Narita, Sawana| Fujii, Akiko| Yamanouchi, Yoshinori| Morinaga, Jun| Yamashita, Satoshi| |
| 抄録 | Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population. |
| キーワード | muscle biopsy antibiotic prophylaxis |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 261 |
| 終了ページ | 264 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577026 |
| Web of Science KeyUT | 000543363400011 |
| NAID | 120006862802 |
| JaLCDOI | 10.18926/AMO/59948 |
|---|---|
| フルテキストURL | 74_3_185.pdf |
| 著者 | Sano, Toshikazu| Ishigami, Shuta| Ito, Tatsuo| Sano, Shunji| |
| 抄録 | Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency. |
| キーワード | heart disease stem cell myocardial regeneration |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 190 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577015 |
| Web of Science KeyUT | 000543363400001 |
| NAID | 120006862790 |
| JaLCDOI | 10.18926/AMO/58272 |
|---|---|
| フルテキストURL | 74_2_137.pdf |
| 著者 | Isozaki, Hiroshi| Yamamoto, Yasuhisa| Sakai, Kunihiko| Sho, Tatuo| Ishihara, Kiyohiro| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro| |
| 抄録 | Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer. |
| キーワード | breast cancer mucinous carcinoma clinicopathological features long-term prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-04 |
| 巻 | 74巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 143 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32341588 |
| Web of Science KeyUT | 000528278500007 |
| NAID | 120006839451 |
| JaLCDOI | 10.18926/AMO/58271 |
|---|---|
| フルテキストURL | 74_2_129.pdf |
| 著者 | Fukuma, Shogo| Shinya, Takayoshi| Soh, Junichi| Fukuhara, Ryuichiro| Ogawa, Nanako| Higaki, Fumiyo| Tanaka, Takehiro| Ichihara, Eiki| Hiraki, Takao| Toyooka, Shinichi| Kanazawa, Susumu| |
| 抄録 | The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types. |
| キーワード | differentiation dynamic computed tomography primary lung cancer enhancement pattern |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-04 |
| 巻 | 74巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 129 |
| 終了ページ | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32341587 |
| Web of Science KeyUT | 000528278500006 |
| NAID | 120006839450 |
| JaLCDOI | 10.18926/AMO/57716 |
|---|---|
| フルテキストURL | 73_6_517.pdf |
| 著者 | Hosogi, Mika| Shiode, Yusuke| Morizane, Yuki| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Toshima, Shinji| Takahashi, Kosuke| Fujiwara, Atsushi| Shiraga, Fumio| |
| 抄録 | We investigated the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 2-year results of 32 eyes of 32 patients who underwent TAE to treat ME due to BRVO. The patients whose treatment interval extended to ≥ 12 weeks were switched to a pro re nata regimen (PRN). For the patients whose treatment interval was <12 weeks, TAE was continued. At 2 years, 10 eyes had required no additional injections after the initial treatment period [recurrence(−) group], whereas the other 22 eyes required additional treatment [recurrence(+) group]. Among the recurrence(+) patients, 11 eyes (34.4% of total) were eventually switched from TAE to PRN; the other 11 eyes (34.4%) continued TAE for 2 years. Visual acuity and central retinal thickness were significantly improved in both the recurrence(+) and (−) groups, and there was no significant betweengroup difference in visual acuity at 2 years. Univariate analyses revealed significant differences in visual acuity (p=0.004), age (p=0.014), and vessel occlusion site (p=0.018) between these groups. Our results suggest that TAE may be effective for BRVO patients with lower visual acuity, older age, and occlusion of a major vein. |
| キーワード | branch retinal vein occlusion macular edema anti-vascular endothelial growth factor ranibizumab treat-and-extend regimen |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-12 |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 517 |
| 終了ページ | 522 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871334 |
| Web of Science KeyUT | 000503431400007 |
| JaLCDOI | 10.18926/AMO/57373 |
|---|---|
| フルテキストURL | 73_5_427.pdf |
| 著者 | Owari, Yutaka| Suzuki, Hiromi| Miyatake, Nobuyuki| |
| 抄録 | The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan. |
| キーワード | Active Guide sedentary behavior elderly people randomized controlled trial health promotion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 427 |
| 終了ページ | 432 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649369 |
| Web of Science KeyUT | 000491886600008 |
| JaLCDOI | 10.18926/AMO/57371 |
|---|---|
| フルテキストURL | 73_5_413.pdf |
| 著者 | Yanagihara, Yutaka| Nishida, Keigo| Watanabe, Ryuta| Koyama, Kanae| Sawada, Yuichiro| Noda, Terutaka| Asai, Seiji | Fukumoto, Tetsuya| Miura, Noriyoshi| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi| |
| 抄録 | Laparoscopic radical cystectomy (LRC) is a standard surgical treatment for muscle-invasive bladder cancer and high-risk non-muscle-invasive bladder cancer. LRC is a less invasive modality than conventional open surgery. Therefore, even elderly patients with invasive bladder cancer may be candidates for LRC. In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.053), cancer-specific survival (CSS) was 79.3% vs. 81.7% (p=0.187), and recurrence-free survival (RFS) was 58.2% vs. 75.7% (p=0.174), respectively. No significant differences were observed in OS, CSS, or RFS between the groups. No significant differences were found between the groups with respect to peri-surgical/oncological outcomes. We conclude that LRC is feasible in elderly patients. |
| キーワード | bladder cancer laparoscopic surgery radical cystectomy elderly patient |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 417 |
| 終了ページ | 418 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649367 |
| Web of Science KeyUT | 000491886600006 |