検索結果 - 岡山大学学術成果リポジトリ

Three highly conserved hydrophobic residues in the predicted α2‐helix of rice NLR protein Pit contribute to its localization and immune induction

フルテキストURL	fulltext20220428-1.pdf
著者	Wang, Qiong\| Li, Yuying\| Kosami, Ken‐ichi\| Liu, Chaochao\| Li, Jing\| Zhang, Dan\| Miki, Daisuke\| Kawano, Yoji\|
キーワード	NLR protein plasma membrane localization self-association effector triggered immunity rice
備考	This is the peer reviewed version of the following article: [Wang, Q., Li, Y., Kosami, K.-i., Liu, C., Li, J., Zhang, D. et al. (2022) Three highly conserved hydrophobic residues in the predicted α2-helix of rice NLR protein Pit contribute to its localization and immune induction. Plant, Cell & Environment, 1– 15. https://doi.org/10.1111/pce.14315], which has been published in final form at https://doi.org/10.1111/pce.14315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\|
発行日	2022-4-7
出版物タイトル	Plant, Cell &amp
巻	45巻
出版者	Wiley
開始ページ	1876
終了ページ	1890
ISSN	0140-7791
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 John Wiley & Sons Ltd.
論文のバージョン	author
PubMed ID	35312080
DOI	10.1111/pce.14315
Web of Science KeyUT	000779738600001
関連URL	isVersionOf https://doi.org/10.1111/pce.14315

Analysis of subgingival microbiota in monozygotic twins with different severity and progression risk of periodontitis

フルテキストURL	fulltext.pdf
著者	Yamamoto, Tadashi\| Taniguchi, Makoto\| Matsunaga, Kazuyuki\| Kawata, Yusuke\| Kawamura, Mari\| Okubo, Keisuke\| Yamashiro, Keisuke\| Omori, Kazuhiro\| Takashiba, Shogo\|
キーワード	disease progression dysbiosis environmental factors microbiome monozygotic twins periodontitis
発行日	2022-04-18
出版物タイトル	Clinical Case Reports
巻	10巻
号	4号
出版者	WILEY
開始ページ	e05725
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35449775
DOI	10.1002/ccr3.5725
Web of Science KeyUT	000783225600001
関連URL	isVersionOf https://doi.org/10.1002/ccr3.5725

The thickness of the ventral medial prefrontal cortex predicts the prior-entry effect for allocentric representation in near space

フルテキストURL	fulltext.pdf
著者	Huang, Jie\| Wang, Aijun\| Tang, Xiaoyu\| Zhang, Ming\|
発行日	2022-04-05
出版物タイトル	Scientific Reports
巻	12巻
号	1号
出版者	Nature Portfolio
開始ページ	5704
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35383294
DOI	10.1038/s41598-022-09837-y
Web of Science KeyUT	000781522600033
関連URL	isVersionOf https://doi.org/10.1038/s41598-022-09837-y

LCZ696 ameliorates doxorubicin-induced cardiomyocyte toxicity in rats

フルテキストURL	fulltext.pdf
著者	Miyoshi, Toru\| Nakamura, Kazufumi\| Amioka, Naofumi\| Hatipoglu, Omer F.\| Yonezawa, Tomoko\| Saito, Yukihiro\| Yoshida, Masashi\| Akagi, Satoshi\| Ito, Hiroshi\|
発行日	2022-03-23
出版物タイトル	Scientific Reports
巻	12巻
号	1号
出版者	Nature Portfolio
開始ページ	4930
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35322164
DOI	10.1038/s41598-022-09094-z
Web of Science KeyUT	000772605500054
関連URL	isVersionOf https://doi.org/10.1038/s41598-022-09094-z

A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor

JaLCDOI	10.18926/AMO/63428
フルテキストURL	76_2_229.pdf
著者	Kono, Takashi\| Monden, Nobuya\| Chikuie, Nobuyuki\| Taruya, Takayuki\| Hamamoto, Takao\| Ishino, Takashi\| Ueda, Tsutomu\| Takeno, Sachio\|
抄録	We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy.
キーワード	head and neck osteosarcomas tumor suppressor p16
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	229
終了ページ	233
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503452
Web of Science KeyUT	000792291900006

Mediastinal and Hilar Lymph Node Metastases from Renal Cell Carcinoma with Concomitant Lung Carcinoma: A Rare Case with Unique Diagnostic Challenges

JaLCDOI	10.18926/AMO/63427
フルテキストURL	76_2_225.pdf
著者	Mori, Yu\| Sano, Yoshifumi\| Sugimoto, Ryujiro\| Sakao, Nobuhiko\| Ryuko, Tsuyoshi\| Takeda, Masashi\| Kitazawa, Riko\| Yukumi, Shungo\| Izutani, Hironori\|
抄録	A 75-year-old man presented to our hospital 1 year after partial renal resection for clear cell carcinoma. A right lower lobe lung nodule noted at the time of surgery had increased to 3.0 cm in diameter and was confirmed as squamous cell lung carcinoma by bronchoscopic cytology. Computed tomography had also revealed paratracheal lymph node swelling. He underwent right lower lobectomy with lymph node dissection by video-assisted thoracic surgery. Pathological examination confirmed squamous cell carcinoma of the lung but diagnosed the right hilar and mediastinal lymph node metastases as clear cell carcinoma.
キーワード	renal cell carcinoma primary lung cancer double cancer mediastinal lymph node metastasis hilar lymph node metastasis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	225
終了ページ	228
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503451
Web of Science KeyUT	000792291900005

A Pediatric Case of Cauda Equina Dermoid Cyst Resected by Minimally Invasive Unilateral Hemilaminectomy

JaLCDOI	10.18926/AMO/63426
フルテキストURL	76_2_217.pdf
著者	Yabuno, Satoru\| Sasada, Susumu\| Umakoshi, Michiari\| Nagase, Takayuki\| Sugahara, Chiaki\| Kawauchi, Satoshi\| Yasuhara, Takao\| Date, Isao\|
抄録	A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery.
キーワード	cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	217
終了ページ	223
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503450
Web of Science KeyUT	000792291900004

Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells

JaLCDOI	10.18926/AMO/63425
フルテキストURL	76_2_203.pdf
著者	Masuda, Tomoya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Ieda, Takeshi\| Kikuchi, Satoru\| Kuroda, Shinji\| Noma, Kazuhiro\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
キーワード	esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	203
終了ページ	215
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503449
Web of Science KeyUT	000792291900003

Association between timing of speech and language therapy initiation and outcomes among post-extubation dysphagia patients: a multicenter retrospective cohort study

フルテキストURL	fulltext.pdf
著者	Hongo, Takashi\| Yamamoto, Ryohei\| Liu, Keibun\| Yaguchi, Takahiko\| Dote, Hisashi\| Saito, Ryusuke\| Masuyama, Tomoyuki\| Nakatsuka, Kosuke\| Watanabe, Shinichi\| Kanaya, Takahiro\| Yamaguchi, Tomoya\| Yumoto, Tetsuya\| Naito, Hiromichi\| Nakao, Atsunori\|
キーワード	Post-extubation dysphagia Speech and language therapy Intensive care Dysphagia Aspiration pneumonia
発行日	2022-04-08
出版物タイトル	Critical Care
巻	26巻
号	1号
出版者	BMC
開始ページ	98
ISSN	1364-8535
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35395802
DOI	10.1186/s13054-022-03974-6
Web of Science KeyUT	000779598400004
関連URL	isVersionOf https://doi.org/10.1186/s13054-022-03974-6

Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma

フルテキストURL	fulltext.pdf
著者	Takatsu, Fumiaki\| Yamamoto, Hiromasa\| Tomioka, Yasuaki\| Tanaka, Shin\| Shien, Kazuhiko\| Suzawa, Ken\| Miyoshi, Kentaroh\| Otani, Shinji\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Takahashi, Katsuhito\| Toyooka, Shinichi\|
キーワード	Retroperitoneal sarcoma Lung metastasis Metastasectomy
発行日	2022-04-08
出版物タイトル	World Journal Of Surgical Oncology
巻	20巻
号	1号
出版者	BMC
開始ページ	114
ISSN	1477-7819
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35395855
DOI	10.1186/s12957-022-02552-y
Web of Science KeyUT	000780301100001
関連URL	isVersionOf https://doi.org/10.1186/s12957-022-02552-y

Silica-associated systemic lupus erythematosus with lupus nephritis and lupus pneumonitis A case report and a systematic review of the literature

フルテキストURL	fulltext.pdf
著者	Fukushima, Kazuhiko\| Uchida, Haruhito A.\| Fuchimoto, Yasuko\| Mifune, Tomoyo\| Watanabe, Mayu\| Tsuji, Kenji\| Tanabe, Katsuyuki\| Kinomura, Masaru\| Kitamura, Shinji\| Miyamoto, Yosuke\| Wada, Sae\| Koyanagi, Taisaku\| Sugiyama, Hitoshi\| Kishimoto, Takumi\| Wada, Jun\|
キーワード	lupus nephritis lupus pneumonitis silicosis SLE
発行日	2022-02-18
出版物タイトル	Medicine
巻	101巻
号	7号
出版者	Lippincott Williams & Wilkins
開始ページ	e28872
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 the Author(s).
論文のバージョン	publisher
PubMed ID	35363197
DOI	10.1097/MD.0000000000028872
Web of Science KeyUT	000776738500059
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000028872

Structural basis for different types of hetero-tetrameric light-harvesting complexes in a diatom PSII-FCPII supercomplex

フルテキストURL	fulltext.pdf
著者	Nagao, Ryo\| Kato, Koji\| Kumazawa, Minoru\| Ifuku, Kentaro\| Yokono, Makio\| Suzuki, Takehiro\| Dohmae, Naoshi\| Akita, Fusamichi\| Akimoto, Seiji\| Miyazaki, Naoyuki\| Shen, Jian-Ren\|
発行日	2022-04-01
出版物タイトル	Nature Communications
巻	13巻
号	1号
出版者	Nature Portfolio
開始ページ	1764
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35365610
DOI	10.1038/s41467-022-29294-5
Web of Science KeyUT	000777408600010
関連URL	isVersionOf https://doi.org/10.1038/s41467-022-29294-5

Relationship between patients' characteristics and efficacy of calcimimetics for primary hyperparathyroidism in the elderly

フルテキストURL	fulltext.pdf
著者	Yamamoto, Koichiro\| Nakano, Yasuhiro\| Tokumasu, Kazuki\| Honda, Hiroyuki\| Hasegawa, Kou\| Sato, Asuka\| Ogawa, Hiroko\| Obika, Mikako\| Hanayama, Yoshihisa\| Otsuka, Fumio\|
キーワード	cinacalcct evocalcet hypercalccmia primary hyperparathyroidism
発行日	2022-04-08
出版物タイトル	Clinical Case Reports
巻	10巻
号	4号
出版者	Wiley
開始ページ	e05713
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35425612
DOI	10.1002/ccr3.5713
Web of Science KeyUT	000781095000001
関連URL	isVersionOf https://doi.org/10.1002/ccr3.5713

Detection of Male Hypogonadism in Patients with Post COVID-19 Condition

フルテキストURL	fulltext.pdf
著者	Yamamoto, Yukichika\| Otsuka, Yuki\| Sunada, Naruhiko\| Tokumasu, Kazuki\| Nakano, Yasuhiro\| Honda, Hiroyuki\| Sakurada, Yasue\| Hagiya, Hideharu\| Hanayama, Yoshihisa\| Otsuka, Fumio\|
キーワード	fatigue hypogonadism LOH syndrome long COVID testosterone
発行日	2022-03-31
出版物タイトル	Journal Of Clinical Medicine
巻	11巻
号	7号
出版者	MDPI
開始ページ	1955
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35407562
DOI	10.3390/jcm11071955
Web of Science KeyUT	000782056600001
関連URL	isVersionOf https://doi.org/10.3390/jcm11071955

Cat scratch disease without a history of cat exposure

フルテキストURL	fulltext.pdf
著者	Oka, Kosuke\| Takagi, Yume\| Hagiya, Hideharu\| Otsuka, Fumio\|
キーワード	cat scratch disease lymphadenopathy and subcutaneous abscess
発行日	2022-04-14
出版物タイトル	Clinical Case Reports
巻	10巻
号	4号
出版者	Wiley
開始ページ	e04816
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35441012
DOI	10.1002/ccr3.4816
Web of Science KeyUT	000782511000001
関連URL	isVersionOf https://doi.org/10.1002/ccr3.4816

Mapping of Nematode Resistance in Hexaploid Sweetpotato Using an Next-Generation Sequencing-Based Association Study

フルテキストURL	fulltext.pdf
著者	Obata, Nozomi\| Tabuchi, Hiroaki\| Kurihara, Miyu\| Yamamoto, Eiji\| Shirasawa, Kenta\| Monden, Yuki\|
キーワード	polyploidy nematode sweetpotato resistant cultivar breeding association study
発行日	2022-03-18
出版物タイトル	Frontiers In Plant Science
巻	13巻
出版者	Frontiers Media SA
開始ページ	858747
ISSN	1664-462X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Obata, Tabuchi, Kurihara, Yamamoto, Shirasawa and Monden.
論文のバージョン	publisher
PubMed ID	35371138
DOI	10.3389/fpls.2022.858747
Web of Science KeyUT	000778596100001
関連URL	isVersionOf https://doi.org/10.3389/fpls.2022.858747

Counterfactual Explanation of Brain Activity Classifiers Using Image-To-Image Transfer by Generative Adversarial Network

フルテキストURL	fulltext.pdf
著者	Matsui, Teppei\| Taki, Masato\| Pham, Trung Quang\| Chikazoe, Junichi\| Jimura, Koji\|
キーワード	fMRI deep learning explainable AI decoding generative neural network counterfactual explanation
発行日	2022-03-16
出版物タイトル	Frontiers In Neuroinformatics
巻	15巻
出版者	Frontiers Media
開始ページ	802938
ISSN	1662-5196
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Matsui, Taki, Pham, Chikazoe and Jimura.
論文のバージョン	publisher
PubMed ID	35369003
DOI	10.3389/fninf.2021.802938
Web of Science KeyUT	000778735900001
関連URL	isVersionOf https://doi.org/10.3389/fninf.2021.802938

MRI multiparametric scoring system for pial blood supply of intracranial meningiomas

フルテキストURL	fulltext.pdf
著者	Higaki, Fumiyo\| Inoue, Satoshi\| Oda, Wakako\| Matsusue, Eiji\| Hiraki, Takao\|
キーワード	pial blood supply peritumoral brain edema arachnoid plane peritumoral flow void magnetic resonance imaging
発行日	2022-04-08
出版物タイトル	Acta Radiologica Open
巻	11巻
号	4号
出版者	Sage Publications Ltd.
ISSN	2058-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35425642
DOI	10.1177/20584601221091208
Web of Science KeyUT	000780184200001
関連URL	isVersionOf https://doi.org/10.1177/20584601221091208

Safety and Effectiveness of Perospirone in Comparison to Risperidone for Treatment of Delirium in Patients with Advanced Cancer: A Multicenter Prospective Observational Study in Real-World Psycho-Oncology Settings

JaLCDOI	10.18926/AMO/63414
フルテキストURL	76_2_195.pdf
著者	Inoue, Shinichiro\| Maeda, Isseki\| Ogawa, Asao\| Yoshiuchi, Kazuhiro\| Terada, Seishi\| Yamada, Norihito\|
抄録	The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event.
キーワード	delirium cancer perospirone risperidone
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	195
終了ページ	202
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503448
Web of Science KeyUT	000792291900002

Association between the Remifentanil Dose during Anesthesia and Postoperative pain

JaLCDOI	10.18926/AMO/63413
フルテキストURL	76_2_187.pdf
著者	Ren, Wanxu\| Matsusaki, Takashi\| Abugri Osman Bright\| Morimatsu, Hiroshi\|
抄録	Remifentanil is an ultra-short-acting opioid that sometimes causes opioid-induced hyperalgesia, which has led to controversy regarding the association between intraoperative remifentanil administration and postoperative pain. This study aimed to assess the effects of the intraoperative remifentanil dose on postoperative pain. Patients undergoing esophageal, gastric/hepatobiliary, or intestinal/colon surgery and using postoperative patient-controlled epidural analgesia were analyzed. The patients were divided into two groups based on the average intraoperative remifentanil dose (high-dose remifentanil [HR] group: ≥0.1 μg/kg/min; low-dose remifentanil [LR] group: <0.1 μg/kg/min). In all, 406 patients met the inclusion criteria. A significant difference in the average dose of remifentanil was seen between the groups during the anesthesia period (0.14±0.05 vs. 0.07±0.02 μg/kg/min). However, no significant difference was seen in pre- or intraoperative patient characteristics. Numerical rating scale (NRS) scores on postoperative day 1 were similar between the groups (HR: 1.7±2.0; LR: 1.7±2.0; p=0.74). The incidence of poor pain control (NRS > 3/10) was also similar between the groups (HR: 14%; LR: 16%; p=0.57). Older age (> 60 years) and type of surgery (esophageal surgery) were associated with worse postoperative NRS scores. No significant association was seen between the intraoperative remifentanil dose and postoperative NRS scores following thoracoabdominal surgery with postoperative epidural pain management.
キーワード	high-dose remifentanil postoperative numerical rating scale type of surgery epidural block
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	187
終了ページ	193
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503447
Web of Science KeyUT	000792291900001