Clinical and histological observations of chorioepithelioma and hydatidiform mole

1. Clinical and histological evaluation of so-called chorioepithelioma malignum and hydatidiform mole has been made on the cases treated at the Department of Obstetrics and Gynecology, Okayama University Hospital during the 20year period friom 1939 to 1958. 2. CC has been confirmed to be a poor risk in the treatment than CA and SE. 3. The two-year cure rate and the five-year cure rate yield an approximate value in each of CC, CA and SE, so that the two-year survival would be an ideal index for determination of the prognosis. 4. It may be pointed out that CC would indicate a tendency of a higher gonadotropin content suggestive of the poor prognosis, provided the disease contain a greater number of La-cells comparing to Sy-cells. 5. Metastasis of CA is not so infrequent as has been formerly believed, and there were two cases, which proved to be a typical SE and had metastasis to the vaginal wall. 6. Concerning the last labor preceding the chorioepithelioma, it has been clarified that the disease occurs more frequently following spontaneous abortion rather than after artificial abortion. 7. It is noted that the mole showing a marked proliferation of the trophoblasts entailed CC. However, in order to evaluate a correlation of the histological findings of the mole with chance occurrence of the subsquent CC, further study on the cases is required.