| ID | 40676 |
| フルテキストURL | |
| タイトル（別表記） | Changes in and the significance of serum immunosuppressive substances (ISS) and NK activity in murine cardiac homotransplantation
|
| 著者 |
木村 隆信
岡山大学医学部第一外科学教室
|
| 抄録 | Heterotopic homotransplantation of rat hearts was performed and ISS and NK activity levels were determined before and after rejection. The effects of prostaglandin (PGE(2)), cyclosporin A, and indomethacin on the acceptance of transplanted hearts as well as on ISS and NK activity were studied. PGE(2) and PGI(2) significantly extended survival when compared to a control group, while indomethacin decreased survival. ISS peaked 4 days before the rejection of transplanted hearts, suggesting its usefulness as a marker of rejection. Moreover, NK activity was significantly higher around the time of rejection, suggesting the importance of NK cells in this process. Finally, rejection was suppressed by administration of PGE(2).
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| キーワード | ラット心移植
ISS
NK細胞活性
プロスタグランジン
インドメサシン
|
| 発行日 | 1990-10
|
| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
|
| 巻 | 102巻
|
| 号 | 9-10号
|
| 出版者 | 岡山医学会
|
| 出版者（別表記） | Okayama Medical Association
|
| 開始ページ | 1083
|
| 終了ページ | 1090
|
| ISSN | 0030-1558
|
| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1083/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
|
| 論文のバージョン | publisher
|
| 査読 |
有り
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| Eprints Journal Name | joma
|
