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著者 Tamura, Hideo|
発行日 2016-01
出版物タイトル Mathematical Journal of Okayama University
58巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/mjou/53917
著者 Tamura, Hideo|
発行日 2016-01
出版物タイトル Mathematical Journal of Okayama University
58巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/mjou/53916
JaLCDOI 10.18926/AMO/53907
フルテキストURL 69_6_333.pdf
著者 Ito, Maiko| Shien, Tadahiko| Kaji, Mitsumasa| Mizoo, Taeko| Iwamoto, Takayuki| Nogami, Tomohiro| Motoki, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Miyoshi, Shinichiro|
抄録 We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (ER)-positive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (>14%) versus low (<14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range:0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p=0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients.
キーワード breast cancer invasive ductal carcinoma 18F-fluorodeoxyglucose positron emission tomography/computed tomography maximum standardized uptake values clinicopathological features
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-12
69巻
6号
出版者 Okayama University Medical School
開始ページ 333
終了ページ 338
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26690243
Web of Science KeyUT 000368434500002
著者 榊原 一郎|
発行日 2015-09-30
出版物タイトル
資料タイプ 学位論文
タイトル(別表記) A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection
フルテキストURL 127_213.pdf
著者 安井 和也| 楳田 祐三| 熊野 健二郎| 田端 雅弘| 大塚 文男| 八木 孝仁| 藤原 俊義|
抄録 A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected. The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs. On pathological and immunopathological findings, the tumor was diagnosed as ectopic pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.
キーワード 異所性褐色細胞腫(ectopic pheochromocytoma) 化学療法(chemo therapy) 131I-MIBG
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
127巻
3号
開始ページ 213
終了ページ 218
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.213
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.213
NAID 130005116814
タイトル(別表記) Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt
フルテキストURL 127_203.pdf
著者 鵜川 豊世武|
抄録 Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction.
キーワード 心拍出量(cardiac output) 心不全(heart failure) 脳性ナトリウム利尿ペプチド(brain natriuretic peptide) 非過大シャント心不全(non-high-output cardiac failure) 腎臓(kidney)
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
127巻
3号
開始ページ 203
終了ページ 207
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.203
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.203
NAID 130005116810
タイトル(別表記) Basic and clinical research regarding vascular endothelial function
フルテキストURL 127_187.pdf
著者 塚原 宏一|
キーワード アルギニン代謝 一酸化窒素 ガス生物学 血管内皮学 酸化ストレス
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
127巻
3号
開始ページ 187
終了ページ 195
ISSN 0030-1558
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.187
NAID 130005116819
JaLCDOI 10.18926/AMO/53672
フルテキストURL 69_5_267.pdf
著者 Inada, Ryo| Nagasaka, Takeshi| Kondo, Yoshitaka| Watanabe, Ayako| Toshima, Toshiaki| Kubota, Nobuhito| Kikuchi, Satoru| Ishida, Michihiro| Kuroda, Shinji| Mori, Yoshiko| Kishimoto, Hiroyuki| Fujiwara, Toshiyoshi|
抄録 The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time.
キーワード laparoscopic surgery total proctocolectomy open proctocolectomy ulcerative colitis case-matched study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-10
69巻
5号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 273
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26490023
Web of Science KeyUT 000365519600002
著者 永井 伊作| Watanabe, Keigo|
発行日 2015-09-28
出版物タイトル IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
資料タイプ 会議発表論文
タイトル(別表記) Successful laparoscopic resection of a cecal tumor in a 95-year-old man
フルテキストURL 127_117.pdf
著者 渡邉 彩子| 稲田 涼| 永坂 岳司| 八木 朝彦| 松本 聖| 戸嶋 俊明| 菊池 覚次| 黒田 新士| 近藤 喜太| 母里 淑子| 岸本 浩行| 藤原 俊義|
抄録 We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials (RCTs) revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients.
キーワード 超高齢者(extremely elderly patient) 大腸癌(colorectal cancer) 腹腔鏡手術(laparoscopic surgery)
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
127巻
2号
開始ページ 117
終了ページ 121
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.117
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.117
NAID 130005096253
JaLCDOI 10.18926/AMO/53337
フルテキストURL 69_2_87.pdf
著者 Murayama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Watanabe, Hirokazu| Shigemitsu, Yusuke| Iwasaki, Yuka| Tokorodani, Chiho| Miyazawa, Mari| Nishiuchi, Ritsuo| Kikkawa, Kiyoshi|
抄録 Ventriculoperitoneal shunts (VPSs) are used for the treatment of hydrocephalus. Here we analyzed the outcomes of VPS placements in 24 infants to determine the risk factors for shunt failure. The infants had undergone the initial VPS operation in our hospital between March 2005 and December 2013. They were observed until the end of January 2014. We obtained Kaplan-Meier curves and performed a multivariate Cox regression analysis of shunt failure. Of the 24 cases, the median (range) values for gestational age, birth weight, and birth head circumference (HC) were 37 (27-39) wks, 2,736 (686-3,788) g, and 35.3 (23.0-45.3) cm, respectively. The total number of shunt procedures was 45. Shunt failure rates were 0.51/shunt and 0.0053/shunt/year. Shunt infection rates were 0.13/shunt and 0.0014/shunt/year. The Kaplan-Meier analysis revealed an increased risk for shunt failure in infants <1 month old or in the HC >90オtile. The Cox regression analysis yielded hazard ratios (HRs) of 2.93 (95オ confidence interval (CI), 0.96-10.95, p=0.059) for age <1 month, and 4.46 (95オCI:1.20-28.91,p=0.023) for the HC >90オtile. The multivariate Cox regression analysis showed adjusted HRs of 17.56 (95オCI:2.69-202.8, p=0.001) for age <1 month, and 2.95 (95オCI:0.52-24.84, p=0.228) for the HC >90オtile. Our findings thus revealed that the risk factors for shunt failure in infants include age <1 month at the initial VPS placement.
キーワード head circumference shunt failure shunt infection ventriculoperitoneal shunt
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-04
69巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 93
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25899630
Web of Science KeyUT 000353181700003
タイトル(別表記) Cholelithiasis with a cholecystoduodenal fistula complicated with paroxysmal nocturnal hemoglobinuria
フルテキストURL 127_35.pdf
著者 加藤 卓也| 松川 啓義| 塩崎 滋弘| 藤 智和| 藤原 康宏| 二宮 基樹|
抄録  In cases of paroxysmal nocturnal hemoglobinuria (PNH), attention must be paid to potential complications such as thrombosis and hemolysis due to perioperative stress and infection from complement activation. Here we present the case of a 61-year-old Japanese woman with PNH. We made the diagnosis of PNH when she was 28 years old, and we administered repeated steroid medication and erythrocyte transfusion. The patient's cholecystocholedocholithiasis with a cholecystoduodenal fistula was diagnosed based on a survey of the right hypochondriac pain. We performed endoscopic nasobiliary drainage (ENBD) for the prophylaxis of perioperative infection, plus a cholecystectomy and fistulectomy. There were no complications, including hemolysis attack, infection, thrombosis with irrigation erythrocyte transfusion, steroid cover, or the need for heparin administration during the perioperative period. The reduction of the complement activation is necessary in the perioperative management of PNH patients. The prevention of the development of acidosis and hypoxemia, the selection of washed red blood cells, steroid use, appropriate infection measures and thrombosis prophylaxis are all important for the prevention of complications.
キーワード 発作性夜間血色素尿症(PNH)(paroxysmal nocturnal hemoglobinuria (PNH)) 胆嚢十二指腸瘻(cholecystoduodenal fistula) 溶血発作(hemolysis)
出版物タイトル 岡山医学会雑誌
発行日 2015-04-01
127巻
1号
開始ページ 35
終了ページ 39
ISSN 0030-1558
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.35
NAID 130005068351
タイトル(別表記) Surgically treated Zenker’s diverticulum: Diverticulectomy and cricopharyngeal myotomy
フルテキストURL 127_19.pdf
著者 二宮 卓之| 金谷 信彦| 勝田 浩| 田中屋 宏爾| 青木 秀樹| 竹内 仁司|
抄録  Zenker's diverticulum is a very rare disease among gastorointestinal diverticulum. We report a case of Zenker's diverticulum successfully treated with diverticulectomy and cricophalyngial myotomy. A 71-year-old male complained of aspirating water for two years. He was diagnosed as Zenker's diverticulum. Due to his severe symptoms, the operation was performed in an open-neck approach. The left recurrent laryngeal nerve was identified and preserved. An incision was made in the diverticulum wall, and the internal diameter of normal cervical esophagus was measured. The diverticulum was then excised with an automatic suture device in the minor axis direction of the esophagus. A cricopharyngeal myotomy was conducted, because this muscle was fibrotic and stiffened. The patient's symptoms disappeared after the operation. Diverticulectomy and cricopharyngeal myotomy through an open-neck approach is a safe and reliable method that follows, direct access to the diverticulum and recurrent laryngeal nerve.
キーワード Zenker憩室(Zenker’s diverticulum) 輪状咽頭筋切開術(cricopharyngeal myotomy) 頚部アプローチ(open-neck approach)
出版物タイトル 岡山医学会雑誌
発行日 2015-04-01
127巻
1号
開始ページ 19
終了ページ 23
ISSN 0030-1558
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.19
NAID 130005068344
JaLCDOI 10.18926/ESR/53194
タイトル(別表記) Aerosol observation at Okayama with Skyradiometer and LIDAR
フルテキストURL esr_021_1_013_021.pdf
著者 永松 慎平| 江川 大貴| 塚本 修|
抄録  Aerosol is one of the controlling parameter for the global climate and also effects on local health hazards. The measurement of the aerosol was originally carried out as in-situ sampling and mass weight measurement including chemical analysis. Recently, remote sensing method is applied as satellite remote sensing and surface based remote sensing. Skyradiometer and LIDAR are surface based remote sensing system. Skyradiometer measures solar radiation as direct and scattered solar radiation affected by aerosols. LIDAR emit laser beam upward and it is backscattered by overlying aerosols. The backscattered light is received by a telescope and vertical distributions of the aerosols are obtained. These measurements require atmospheric radiation physics.  A Skyradiometer and a LIDAR were operated continuously at Okayama University campus and aerosol parameters were obtained from both of the system. Seasonal variations of the AOT (Aerosol Optical Thickness) and Angstrom parameter (α) are evaluated. During some dust events (e.g. yellow sand and PM2.5), time variations of these parameters were identified from both of the measurement system.
キーワード Aerosol Skyradiometer LIDAR Aerosol Optical Thickness (AOT)
出版物タイトル Okayama University Earth Science Report
発行日 2014-12-27
21巻
1号
開始ページ 13
終了ページ 21
ISSN 1340-7414
言語 日本語
著作権者 © 2014 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved
論文のバージョン publisher
NAID 120005567873
著者 安場 健一郎|
発行日 2015-02-01
出版物タイトル 岡山大学農学部学術報告
104巻
資料タイプ 紀要論文
著者 上村 一雄| 長田 臨| 菊本 愛生| Sharmin, Sultana| 若井 暁| 金尾 忠芳|
発行日 2015-02-01
出版物タイトル 岡山大学農学部学術報告
104巻
資料タイプ 紀要論文
著者 Kondo, Yoshitaka| Nagasaka, Takeshi| Kobayashi, Satoru| Kobayashi, Naoya| Fujiwara, Toshiyoshi|
発行日 2014-03
出版物タイトル Hepato-Gastroenterology
61巻
130号
資料タイプ 学術雑誌論文
著者 Yamada, Eiji| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Sakuma, Leon| Takaoka, Munenori| Yamada, Takako| Noma, Kazuhiro| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Tanabe, Shunsuke| Nagasaka, Takeshi| Fujiwara, Toshiyoshi| Naomoto, Yoshio|
発行日 2012-12
出版物タイトル Journal of Surgical Research
178巻
2号
資料タイプ 学術雑誌論文
タイトル(別表記) Giant rectal gastrointestinal stromal tumor successfully resected by abdominoperineal resection combined with posterior vaginal wall resection
フルテキストURL 126_217.pdf
著者 岩川 和秀| 西江 学| 徳永 尚之| 宮宗 秀明| 岩垣 博巳|
抄録 We report a case of giant rectal gastrointestinal stromal tumor (GIST) successfully resected by abdominoperineal resection combined with posterior vaginal wall resection. Our patient was a 79-year-old woman had been diagnosed as having von Recklinghausen disease at the age of 30 years. In 2006, a computed tomography (CT) scan revealed a tumor originating from the posterior wall of the rectum. In June 2010, she was admitted to our hospital with the chief complaint of bloody stool. A CT scan revealed a giant tumor that had increased to 9cm in size. Colonoscopy demonstrated a submucosal tumor, which was subsequently diagnosed by biopsy as a GIST. Due to the patient's continuous bleeding and abdominal pain, an emergent abdominoperineal resection was performed at that time. The tumor, which measured 8×9cm, was immunohistochemically positive for c-kit and CD34. Concomitant resection of the posterior wall of the vagina via the perineal approach provided a wide area to expose the tumor for a safe operation. The patient has been well with no sign of recurrence since the operation. This procedure is recommended as a useful approach for giant rectal GISTs or rectal cancer with invasion of the posterior pelvic wall.
キーワード 巨大直腸GIST(giant rectal GIST) 腹会陰式直腸切断術(abdominoperineal resection)
出版物タイトル 岡山医学会雑誌
発行日 2014-12-01
126巻
3号
開始ページ 217
終了ページ 221
ISSN 0030-1558
言語 日本語
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.126.217
NAID 130004903245
著者 箕輪 弘嗣| 宗澤 良臣| 鈴木 和彦|
発行日 2012-10-15
出版物タイトル 安全工学
51巻
5号
資料タイプ 学術雑誌論文