| ID | 13951 |
| Eprint ID | 13951
|
| フルテキストURL | |
| タイトル（別表記） | Evaluation of anthracycline-anthraquinone analogues in the treatment of lung cancer using colony assay Part 2. Comparison of cytotoxic effect of anthracycline-anthraquinone analogues in tumor specimens obtained from lung cancer patients
|
| 著者 |
沼田 健之
岡山大学医学部第二内科学教室
|
| 抄録 | The drug sensitivity test using a human tumor clonogenic assay is an in vitro technique providing a high degree of accuracy for predicting the clinical response to anticancer drugs. The author applied this assay to compare the in vitro anticancer efffects of four anthracycline-anthraquinone analogues against lung cancer. The drugs tested in the present study were adriamycin(ADM), aclarubicin(ACR), THP-adriamycin(THP-ADM) and mitoxantrone(MIT). A tumor was defined as sensitive, when the suviving fraction of colony-forming units was reduced 70% or more at a clinically achievable plasma concentration of these drugs in man. Tumor specimens from 100 individual patients were placed in culture. Forty-five specimens (45%) formed enough colonies to test durg sensitivity. Fourteen of the 31 specimens(45%) tested were found to be sensitive fof ACR, 15 of 35(43%) for THP-ADM, 10 of 30(33%) for MIT, and 7 of 43(16%) for ADM. These fingings indicated that the activity of ACR and THP-ADM is stronger than that of ADM in the treatment of lung cancer.
|
| キーワード | 肺癌腫瘍材料
colony assay
anthracycline
anthraquinone
|
| 発行日 | 1993-02-27
|
| 出版物タイトル |
岡山医学会雑誌
|
| 出版物タイトル（別表記） | Journal of Okayama Medical Association
|
| 巻 | 105巻
|
| 号 | 1-2号
|
| 出版者 | 岡山医学会
|
| 出版者（別表記） | Okayama Medical Association
|
| 開始ページ | 81
|
| 終了ページ | 86
|
| ISSN | 0030-1558
|
| NCID | AN00032489
|
| 資料タイプ |
学術雑誌論文
|
| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_81/_article/-char/ja/
|
| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
|
| 言語 |
日本語
|
| 著作権者 | 岡山医学会
|
| 論文のバージョン | publisher
|
| 査読 |
有り
|
| Eprints Journal Name | joma
|
