検索結果 - 岡山大学学術成果リポジトリ

Regulation of germination by targeted mutagenesis of grain dormancy genes in barley

フルテキストURL	fulltext.pdf
著者	Hisano, Hiroshi\| Hoffie, Robert E.\| Abe, Fumitaka\| Munemori, Hiromi\| Matsuura, Takakazu\| Endo, Masaki\| Mikami, Masafumi\| Nakamura, Shingo\| Kumlehn, Jochen\| Sato, Kazuhiro\|
キーワード	Hordeum vulgare seed dormancy targeted genome modification CRISPR Cas9 nuclease pre-harvest sprouting
発行日	2021-08-29
出版物タイトル	Plant Biotechnology Journal
出版者	Wiley
開始ページ	1
終了ページ	10
ISSN	1467-7644
NCID	AA11805223
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34459083
DOI	10.1111/pbi.13692
Web of Science KeyUT	000695529500001
関連URL	isVersionOf https://doi.org/10.1111/pbi.13692

Identification of a Novel Quinvirus in the Family Betaflexiviridae That Infects Winter Wheat

フルテキストURL	fulltext.pdf
著者	Kondo, Hideki\| Yoshida, Naoto\| Fujita, Miki\| Maruyama, Kazuyuki\| Hyodo, Kiwamu\| Hisano, Hiroshi\| Tamada, Tetsuo\| Andika, Ida Bagus\| Suzuki, Nobuhiro\|
キーワード	Betaflexiviridae quinvirus bymovirus yellow mosaic disease wheat virome soil borne variants
発行日	2021-08-19
出版物タイトル	Frontiers In Microbiology
巻	12巻
出版者	Frontiers Media SA
開始ページ	715545
ISSN	1664-302X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Kondo, Yoshida, Fujita, Maruyama, Hyodo, Hisano, Tamada, Andika and Suzuki.
論文のバージョン	publisher
PubMed ID	34489904
DOI	10.3389/fmicb.2021.715545
Web of Science KeyUT	000692554100001
関連URL	isVersionOf https://doi.org/10.3389/fmicb.2021.715545

Clinical Parameters Reflecting Globe/orbit Volume Imbalances in Japanese Acquired Esotropia Patients with High Myopia but without Abduction Limitations

JaLCDOI	10.18926/AMO/62396
フルテキストURL	75_4_447.pdf
著者	Kono, Reika\| Hamasaki, Ichiro\| Kishimoto, Fumiko\| Ohtuski, Hiroshi\| Shibata, Kiyo\| Morizane, Yuki\| Shiraga, Fumio\|
抄録	In high myopia, eye dislocation due to increased globe volume or tight orbital volume causes acquired esotro-pia. GOR (globe/orbit volume ratio), an indicator of the degree of progression of this pathology, was investi-gated the relationships among easily obtained clinical parameters. In this retrospective study, 20 eyes from 10 acquired esotropia patients with high myopia but without abduction limitations were examined. The mean age of the patients was 63.7 ± 8.2 years (mean ± standard deviation). Volumes were measured on the three-dimen-sional fast imaging employing steady-state acquisition magnetic resonance imaging images using the vol-ume-measurement function. Correlations between GOR and the displacement angle of the globe (DA), axial length (AL), and equatorial diameter (ED) were investigated. Mean DA, AL, ED, and GOR values were 107.5 ± 8.5°, 28.86 ± 1.92 mm, 25.00 ± 1.16 mm, and 0.36 ± 0.05, respectively. Only AL was correlated with GOR (p < 0.0001, R2 = 0.6649); DA (p = 0.30, R2 = 0.0633) and ED (p = 0.91, R2 = 0.0008) were not. AL was the only clinically available parameter to indicate globe/orbit volume imbalances in acquired esotropia with high myopia but without abduction limitation. AL may be important for the clinical assessment of the progression of this pathology.
キーワード	acquired esotropia high myopia (high myopes) globe volume magnetic resonance imaging limitation of abduction
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	447
終了ページ	453
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511611
Web of Science KeyUT	000697944600006
NAID	120007146039

Association between higher pericoronary adipose tissue attenuation measured by coronary computed tomography angiography and nonalcoholic fatty liver disease A matched case-control study

フルテキストURL	fulltext.pdf
著者	Ichikawa, Keishi\| Miyoshi, Toru\| Osawa, Kazuhiro\| Miki, Takashi\| Morimitsu, Yusuke\| Akagi, Noriaki\| Nakashima, Mitsutaka\| Ito, Hiroshi\|
キーワード	coronary computed tomography angiography non-alcoholic fatty liver disease perivascular coronary inflammation
発行日	2021-08-27
出版物タイトル	Medicine
巻	100巻
号	34号
出版者	Lippincott Williams & Wilkins
開始ページ	e27043
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 the Author(s).
論文のバージョン	publisher
PubMed ID	34449489
DOI	10.1097/MD.0000000000027043
Web of Science KeyUT	000691370700047
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000027043

Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis

フルテキストURL	fulltext.pdf
著者	Yoshikawa, Yuri\| Izawa, Takashi\| Hamada, Yusaku\| Takenaga, Hiroko\| Wang, Ziyi\| Ishimaru, Naozumi\| Kamioka, Hiroshi\|
発行日	2021-07-21
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Portfolio
開始ページ	14927
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34290363
DOI	10.1038/s41598-021-94470-4
Web of Science KeyUT	000687318300008
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-94470-4

Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments

フルテキストURL	fulltext20210831-3.pdf
著者	Shirakawa, Yasuhiro\| Tazawa, Hiroshi\| Tanabe, Shunsuke\| Kanaya, Nobuhiko\| Noma, Kazuhiro\| Koujima, Takeshi\| Kashima, Hajime\| Kato, Takuya\| Kuroda, Shinji\| Kikuchi, Satoru\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Kanazawa, Susumu\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
キーワード	Telomerase adenovirus radiotherapy esophageal cancer immunotherapy
備考	© 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .\|
発行日	2021-8
出版物タイトル	European Journal of Cancer
巻	153巻
出版者	Elsevier BV
開始ページ	98
終了ページ	108
ISSN	0959-8049
NCID	AA1075407X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Elsevier Ltd.
論文のバージョン	author
PubMed ID	34153720
DOI	10.1016/j.ejca.2021.04.043
Web of Science KeyUT	000686051300013
関連URL	isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043

Predictive Value of the Cardio-Ankle Vascular Index for Cardiovascular Events in Patients at Cardiovascular Risk

フルテキストURL	fulltext.pdf
著者	Miyoshi, Toru\| Ito, Hiroshi\| Shirai, Kohji\| Horinaka, Shigeo\| Higaki, Jitsuo\| Yamamura, Shigeo\| Saiki, Atsuhito\| Takahashi, Mao\| Masaki, Mitsuru\| Okura, Takafumi\| Kotani, Kazuhiko\| Kubozono, Takuro\| Yoshioka, Ryo\| Kihara, Hajime\| Hasegawa, Koji\| Satoh-Asahara, Noriko\| Orimo, Hajime\|
キーワード	arterial stiffness blood pressure cardiovascular events pulse-wave velocity risk factor
発行日	2021-08-17
出版物タイトル	Journal of The American Heart ASSOCIATION
巻	10巻
号	16号
出版者	Wiley
開始ページ	e020103
ISSN	2047-9980
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34369198
DOI	10.1161/JAHA.120.020103
Web of Science KeyUT	000685396200026
関連URL	isVersionOf https://doi.org/10.1161/JAHA.120.020103

Evaluation of a point-of-care serum creatinine measurement device and the impact on diagnosis of acute kidney injury in pediatric cardiac patients: A retrospective, single center study

フルテキストURL	fulltext.pdf
著者	Kimura, Satoshi\| Iwasaki, Tatsuo\| Shimizu, Kazuyoshi\| Kanazawa, Tomoyuki\| Kawase, Hirokazu\| Shioji, Naohiro\| Kuroe, Yasutoshi\| Isoyama, Satoshi\| Morimatsu, Hiroshi\|
キーワード	acute kidney injury cardiac surgical procedures children creatinine point-of-care
発行日	2019-11-24
出版物タイトル	Health Science Reports
巻	3巻
号	1号
出版者	Wiley
開始ページ	e143
ISSN	2398-8835
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	32166189
DOI	10.1002/hsr2.143
Web of Science KeyUT	000682995400005
関連URL	isVersionOf https://doi.org/10.1002/hsr2.143

Total vascular resistance, augmentation index, and augmentation pressure increase in patients with peripheral artery disease

フルテキストURL	fulltext.pdf
著者	Takemoto, Rika\| Uchida, Haruhito A.\| Toda, Hironobu\| Okada, Ken\| Otsuka, Fumio\| Ito, Hiroshi\| Wada, Jun\|
キーワード	augmentation index augmentation pressure peripheral arterial disease total vascular resistance
発行日	2021-08-13
出版物タイトル	Medicine
巻	100巻
号	32号
出版者	Wolters Kluwer Health, Inc.
開始ページ	e26931
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 the Author(s).
論文のバージョン	publisher
PubMed ID	34397939
DOI	10.1097/MD.0000000000026931
Web of Science KeyUT	000683492600068
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000026931

Emergency Dispatches for Suicide Attempts During the COVID-19 Outbreak in Okayama, Japan: A Descriptive Epidemiological Study

フルテキストURL	fulltext.pdf
著者	Habu, Hiroshi\| Takao, Soshi\| Fujimoto, Ryohei\| Naito, Hiromichi\| Nakao, Atsunori\| Yorifuji, Takashi\|
キーワード	COVID-19 epidemiology emergency medical dispatch suicide
発行日	2021-07-17
出版物タイトル	Journal of Epidemiology
巻	31巻
号	9号
出版者	Japan Epidemiological Assoc.
開始ページ	511
終了ページ	517
ISSN	0917-5040
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Hiroshi Habu et al.
論文のバージョン	publisher
PubMed ID	34176855
DOI	10.2188/jea.JE20210066
Web of Science KeyUT	000680719500003
関連URL	isVersionOf https://doi.org/10.2188/jea.JE20210066

An Evaluation of the Safety and Feasibility of Adenosine-assisted Clipping Surgery for Unruptured Cerebral Aneurysms: Study Protocol

フルテキストURL	fulltext.pdf
著者	Hishikawa, Tomohito\| Murai, Satoshi\| Hiramatsu, Masafumi\| Haruma, Jun\| Nishi, Kazuhiko\| Ebisudani, Yuki\| Sato, Yu\| Yasuhara, Takao\| Sugiu, Kenji\| Shimizu, Kazuyoshi\| Kobayashi, Motomu\| Nakagawa, Koji\| Kimura-Ono, Aya\| Hotta, Katsuyuki\| Morimatsu, Hiroshi\| Date, Isao\|
キーワード	adenosine clipping unruptured cerebral aneurysm
発行日	2021
出版物タイトル	Neurologia Medico-Chirurgica
巻	61巻
号	7号
出版者	Japan Neurosurgical Soc.
開始ページ	393
終了ページ	396
ISSN	0470-8105
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Japan Neurosurgical Society
論文のバージョン	publisher
PubMed ID	34024879
DOI	10.2176/nmc.st.2021-0018
Web of Science KeyUT	000672804200001
関連URL	isVersionOf https://doi.org/10.2176/nmc.st.2021-0018

ABO Blood Incompatibility Positively Affects Early Graft Function: Single-Center Retrospective Cohort Study

フルテキストURL	fulltext20210721-2.pdf figure20210721-2.pdf
著者	Watari, Shogo\| Araki, Motoo\| Wada, Koichiro\| Yoshinaga, Kasumi\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Kubota, Risa\| Nishimura, Shingo\| Kobayashi, Yasuyuki\| Takeuchi, Hidemi\| Tanabe, Katsuyuki\| Kitagawa, Masashi\| Morinaga, Hiroshi\| Kitamura, Shinji\| Sugiyama, Hitoshi\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
備考	© 2021 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.transproceed.2021.03.043] . \|
発行日	2021-4-28
出版物タイトル	Transplantation Proceedings
巻	53巻
号	5号
出版者	Elsevier BV
開始ページ	1494
終了ページ	1500
ISSN	0041-1345
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33931247
DOI	10.1016/j.transproceed.2021.03.043
Web of Science KeyUT	000668604400017
関連URL	isVersionOf https://doi.org/10.1016/j.transproceed.2021.03.043

Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients

フルテキストURL	fulltext.pdf
著者	Ueta, Eijiro\| Tsutsumi, Koichiro\| Kato, Hironari\| Matsushita, Hiroshi\| Shiraha, Hidenori\| Fujii, Masakuni\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
発行日	2021-06-10
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	12298
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34112884
DOI	10.1038/s41598-021-91804-0
Web of Science KeyUT	000663785600048
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-91804-0

Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins

フルテキストURL	fulltext20210706-1.pdf
著者	Doi, Seita\| Fujioka, Naoki\| Ohtsuka, Satomi\| Kondo, Rina\| Yamamoto, Maho\| Denda, Miwako\| Magari, Masaki\| Kanayama, Naoki\| Hatano, Naoya\| Morishita, Ryo\| Hasegawa, Takafumi\| Tokumitsu, Hiroshi\|
備考	©2021 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ceca.2021.102404] .\|
発行日	2021-6
出版物タイトル	Cell Calcium
巻	96巻
出版者	Elsevier BV
開始ページ	102404
ISSN	0143-4160
NCID	AA00142099
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Copyright © 2021 Elsevier Ltd. All rights reserved
論文のバージョン	author
PubMed ID	33831707
DOI	10.1016/j.ceca.2021.102404
Web of Science KeyUT	000663580100007
関連URL	isVersionOf https://doi.org/10.1016/j.ceca.2021.102404

Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression

フルテキストURL	fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
著者	Sugiu, Kazuhisa\| Tazawa, Hiroshi\| Hasei, Joe\| Yamakawa, Yasuaki\| Omori, Toshinori\| Komatsubara, Tadashi\| Mochizuki, Yusuke\| Kondo, Hiroya\| Osaki, Shuhei\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kunisada, Toshiyuki\| Ueda, Koji\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
キーワード	Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
備考	This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5\|
発行日	2021-6-10
出版物タイトル	Cancer Chemotherapy and Pharmacology
巻	88巻
号	3号
出版者	Springer Science and Business Media LLC
開始ページ	513
終了ページ	524
ISSN	0344-5704
NCID	AA00598397
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	34114067
DOI	10.1007/s00280-021-04310-5
Web of Science KeyUT	000659839700002
関連URL	isVersionOf https://doi.org/10.1007/s00280-021-04310-5

Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia

JaLCDOI	10.18926/AMO/62232
フルテキストURL	75_3_363.pdf
著者	Tanioka, Nohito\| Shimizu, Hiroko\| Omori, Emiko\| Takahashi, Toru\| Yamaoka, Masakazu\| Morimatsu, Hiroshi\|
抄録	Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver.
キーワード	heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	363
終了ページ	372
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176941
Web of Science KeyUT	000667147700012
NAID	120007089829

Texture Indices of 18F-FDG PET/CT for Differentiating Squamous Cell Carcinoma and Non-Hodgkin’s Lymphoma of the Oropharynx

JaLCDOI	10.18926/AMO/62230
フルテキストURL	75_3_351.pdf
著者	Mitamura, Katsuya\| Norikane, Takashi\| Yamamoto, Yuka\| Ihara-Nishishita, Ayumi\| Kobata, Takuya\| Fujimoto, Kengo\| Takami, Yasukage\| Kudomi, Nobuyuki\| Hoshikawa, Hiroshi\| Nishiyama, Yoshihiro\|
抄録	We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx.
キーワード	18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	351
終了ページ	356
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176939
Web of Science KeyUT	000667147700010
NAID	120007089827

Efficacy and Safety of Early Intravenous Landiolol on Myocardial Salvage in Patients with ST-segment Elevation Myocardial Infarction before Primary Percutaneous Coronary Intervention: A Randomized Study

JaLCDOI	10.18926/AMO/62220
フルテキストURL	75_3_289.pdf
著者	Miyamoto, Masakazu\| Osawa, Kazuhiro\| Miyoshi, Toru\| Mori, Atsushi\| Yoshikawa, Masaki\| Oka, Takefumi\| Ichikawa, Keishi\| Nakamura, Kazufumi\| Ito, Hiroshi\|
抄録	Early treatment with an oral β-blocker is recommended in patients with a ST-segment–elevation myocardial infarction (STEMI). In this multicenter study, we evaluated the effects of a continuous administration of landiolol, an ultrashort-acting β-blocker, before primary percutaneous coronary intervention (PCI) on myocardial salvage and its safety in STEMI patients. A total of 47 Japanese patients with anterior or lateral STEMI undergoing a primary PCI within 12 h of symptom onset were randomized to receive intravenous landiolol (started at 3 μg/min/kg dose and continued to a total of 50 mg; n=23) or not (control; n=24). Patients with Killip class III or more were excluded. The primary outcome was the myocardial salvage index on cardiac magnetic resonance imaging (MRI) performed 5-7 days after the PCI. Cardiac MRI was performed in 35 patients (74%). The myocardial salvage index in the landiolol group was significantly greater than that in the control group (44.4±14.6% vs. 31.7±18.9%, respectively; p=0.04). There were no significant differences in adverse events at 24 h between the landiolol and control groups. A continuous administration of landiolol before a primary PCI may increase the degree of myocardial salvage without additional hemodynamic adverse effects within the first 24 h after STEMI.
キーワード	myocardial infarction landiolol magnetic resonance imaging STEMI PCI
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	289
終了ページ	297
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176932
Web of Science KeyUT	000667147700004
NAID	120007089835

Histidine-rich glycoprotein as a prognostic biomarker for sepsis

フルテキストURL	fulltext.pdf
著者	Kuroda, Kosuke\| Ishii, Kenzo\| Mihara, Yuko\| Kawanoue, Naoya\| Wake, Hidenori\| Mori, Shuji\| Yoshida, Michihiro\| Nishibori, Masahiro\| Morimatsu, Hiroshi\|
発行日	2021-05-13
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	10223
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	33986340
DOI	10.1038/s41598-021-89555-z
NAID	120007053368
Web of Science KeyUT	000656946100013
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-89555-z

Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression

フルテキストURL	fulltext.pdf
著者	Omori, Toshinori\| Tazawa, Hiroshi\| Yamakawa, Yasuaki\| Osaki, Shuhei\| Hasei, Joe\| Sugiu, Kazuhisa\| Komatsubara, Tadashi\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
キーワード	Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein
発行日	2021-04-22
出版物タイトル	PLoS ONE
巻	16巻
号	4号
出版者	Public Library Science
開始ページ	e0250643
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Omori et al.
論文のバージョン	publisher
PubMed ID	33886686
DOI	10.1371/journal.pone.0250643
NAID	120007045007
Web of Science KeyUT	000644138300019
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0250643