担癌生体に及ぼす脾臓摘出の影響に関する実験的研究 Ⅲ. Brown-Pearee腫瘍組織抽出液感作粒子凝集反応と，これに及ぼす脾臓摘出の影響

The author found that the existence of induced antibodies in the sera of rabbits bearing Brown-Pearce Tumor (B. P. T.), which agglutinated such parti-cles as O-typed human red blood cells, Caolin and India-ink, adsorbed on their surface antigenic substances in physiologic saline extract of B. P. T. And this induced antibodies were found not to be tumor-specific, from the facts that particles sensitixed with physiologic saline extract of tissue of the liver and kidney obtained from the same rabbit as tissue of the tumor was taken, were also agglutinated by the serum of rabbit bearing B. P. T, and that particles sensitized with the extract of B. P. T. was aggletinated by the serum of rabbit immunized with tissue of the liver of the same species. But the author could not help presuming the existence of specific anti-body in the serum of rabbit bearing B. P. T. from the experimental results presenting that particles sensitized with the extract of B. P. T. were agglutinated in the most high titer by the serum of rabbit bearing B. P. T. and after the cessation of agglutinin formation for the particles sensitized with tissue of the liver, that for the particles sensitized with B. P. T. still continued on. Splenctomy had no remarkable influence on the ability of this agglutinin formation in rabbits bearing B. P. T. It would be concluded that the significance of splenectomy on the formation of anticarcinomatous antibody must be studied further, under the condition presenting strictly the tumor specific immune reaction.